分类: 核科学技术 >> 核材料与工艺技术 提交时间: 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要: This study investigated the impact of simulated microgravity on acute injury induced by low doses of carbon ions in male reproductive organs of mice, and determined alterations in spermatogenic function and expression levels of apoptotic factors in mice following exposure to acute irradiation after 7 days of simulated microgravity. The results demonstrated that significant reductions in spermatozoa, primary spermatocytes and spermatogonia, and increased globular cells in seminiferous tubule and pro-apoptotic proteins were observed in the group exposed to over 0.4 Gy irradiation. Collectively, the data suggest that lesions inflicted by simulated microgravity are not markedly modified by lower doses of irradiation (0.2 Gy) in mouse testis compared to the control group. However, testicular impairments were markedly evident in the group exposed to higher doses of carbon ions plus simulated microgravity, which may be due at least in part to elevated apoptosis initiated by the mitochondrial apoptosis pathway in germ cells.
分类: 核科学技术 >> 核材料与工艺技术 提交时间: 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要: We evaluated the protective effect of N-acetylcysteine (NAC) on immunity system irradiated by 12C6+ ion beam. Kun-Ming mice were whole-body irradiated by 12C6+ ion at doses of 0, 0.5, 1, 1.5, 2, 2.5 and 3 Gy. The results showed that in saline group, the lymphocytes DNA double-strand breaks (DSBs), maleic dialdehyde, thymocytes number in G0/G1 and apoptosis percentage increased with dose increment, and the levels of interferon-, glutathione, superoxide radical (SOD) and natural killer cells activity decreased with dose increment. However, there were no significant changes in NAC-treated group. The data indicated that pre-treatment with NAC could significantly remove the ROS by counteracting the glutamate, decrease excessive lipid peroxidation reaction and SOD damages, and protect DNA, lymphocytes and cytokines against irradiation.
分类: 地球科学 >> 地理学 提交时间: 2021-04-30 合作期刊: 《干旱区科学》
摘要: Snow avalanches are a common natural hazard in many countries with seasonally snow-covered mountains. The avalanche hazard varies with snow avalanche type in different snow climate regions and at different times. The ability to understand the characteristics of avalanche activity and hazards of different snow avalanche types is a prerequisite for improving avalanche disaster management in the mid-altitude region of the Central Tianshan Mountains. In this study, we collected data related to avalanche, snowpack, and meteorology during four snow seasons (from 2015 to 2019), and analysed the characteristics and hazards of different types of avalanches. The snow climate of the mid-altitude region of the Central Tianshan Mountains was examined using a snow climate classification scheme, and the results showed that the mountain range has a continental snow climate. To quantify the hazards of different types of avalanches and describe their situation over time in the continental snow climate region, this study used the avalanche hazard degree to assess the hazards of four types of avalanches, i.e., full-depth dry snow avalanches, full-depth wet snow avalanches, surface-layer dry snow avalanches, and surface-layer wet snow avalanches. The results indicated that surface-layer dry snow avalanches were characterized by large sizes and high release frequencies, which made them having the highest avalanche hazard degree in the Central Tianshan Mountains with a continental snow climate. The overall avalanche hazard showed a single peak pattern over time during the snow season, and the greatest hazard occurred in the second half of February when the snowpack was deep and the temperature increased. This study can help the disaster and emergency management departments rationally arrange avalanche relief resources and develop avalanche prevention strategies.