Urine Proteomics in Methamphetamine Addicted Patients

Subjects: Biology >> Biochemistry submitted time 2024-06-18

Ziyun Shen Juncheng Liang Shuxuan Tang Xuanzhen Pan Yijin Bao Yanping Deng Youhe Gao

Abstract： Drug addiction is a serious chronic relapsing brain disease, and methamphetamine dependence has a complex course and is difficult to treat, causing a serious public health burden. In this study, we compared and analyzed the urine proteome of methamphetamine-using patients (patients who stopped using methamphetamine within 24 hours), methamphetamine-withdrawing patients (patients who stopped using drugs for more than 3 months and entered rehabilitation treatment), healthy individuals. The urine proteome of methamphetamine-addicted patients (including patients who were using methamphetamine and methamphetamine-withdrawing patients) was significantly different from that of healthy individuals, and some differential proteins and their enriched biological functions showed that they were associated with addiction or neurotoxicity of methamphetamine and may be potential intervention targets for drug addiction. Patients who withdrew methamphetamine for more than 3 months were still difficult to return to normal levels and may be used to reveal the reasons for the high rate of methamphetamine relapse. In this study, a method of studying addictive drugs from the perspective of urine proteomics was established, which proved that urine proteome can reflect the effects of methamphetamine abuse on the body relatively systematically and comprehensively, and has the potential to provide clues for the study and practice of clinical addictive diseases.

Peer Review Status:Awaiting Review

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