N-acetylcysteine protect lymphocytes and cytokines against heavy ion irradiation via counteracting the glutamate

Subjects: Nuclear Science and Technology >> Nuclear Materials and Techniques submitted time 2023-06-18 Cooperative journals: 《Nuclear Science and Techniques》

XIE Yi ZHANG Hong WANG Yipei LIU Yang CHEN Yingtai

Abstract： We evaluated the protective effect of N-acetylcysteine (NAC) on immunity system irradiated by ¹²C⁶⁺ ion beam. Kun-Ming mice were whole-body irradiated by ¹²C⁶⁺ ion at doses of 0, 0.5, 1, 1.5, 2, 2.5 and 3 Gy. The results showed that in saline group, the lymphocytes DNA double-strand breaks (DSBs), maleic dialdehyde, thymocytes number in G₀/G₁ and apoptosis percentage increased with dose increment, and the levels of interferon-γ, glutathione, superoxide radical (SOD) and natural killer cells activity decreased with dose increment. However, there were no significant changes in NAC-treated group. The data indicated that pre-treatment with NAC could significantly remove the ROS by counteracting the glutamate, decrease excessive lipid peroxidation reaction and SOD damages, and protect DNA, lymphocytes and cytokines against irradiation.

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