Subjects: Biology >> Biochemistry submitted time 2020-02-12
Yingxia Liu
Cong Zhang
Fengming Huang
Yang Yang
Fuxiang Wang
Jing Yuan
Zheng Zhang
Yuhao Qin
Xiaoyun Li
Dandan Zhao
Shunwang Li
Shuguang Tan
Zhaoqin Wang
Jinxiu Li
Chenguang Shen
Jianming Li
Ling Peng
Weibo Wu
Mengli Cao
Li Xing
Abstract： A recent outbreak of pneumonia in Wuhan, China was caused by 2019 novel coronavirus (2019-nCoV). Here we reported 12 patients with 2019-nCoV infections in Shenzhen, China; all of them developed pneumonia and half developed acute respiratory distress syndrome (ARDS). We demonstrated the plasma cytokine profiles of these 12 patients. Thirty-eight out of 48 cytokines measured in the plasmas of 2019-nCoV infected patients were significantly elevated compared to healthy individuals. Seventeen cytokines were linked to 2019-nCoV load. Fifteen cytokines, M-CSF, IL-10, IFN-2, IL-17, IL-4, IP-10, IL-7, IL-1ra, G-CSF, IL-12, IFN-γ, IL-1, IL-2, HGF, and PDGF-BB, were strongly associated with lung injury Murray score, and could predict disease severity of 2019-nCoV infections according to area under the curve (AUC) of the receiver-operating characteristics (ROC) calculations. Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines, some of these cytokines could be potential biomarkers of disease severity of 2019-nCoV infections. These findings improve our understanding of the immunopathologic mechanisms of this emerging and still evolving disease and suggest that modulators of cytokine responses could play a therapeutic role in combating the disease. " "
Peer Review Status:
Awaiting Review
Hits
Hits
Downloads
Comment