Microcirculation Dysfunction in Age-related Cognitive Impairment

分类： 生物学 >> 生物物理学 >> 生物物理、生物化学与分子生物学 提交时间： 2016-05-11

Chen Xi-Xi Su Tao Chen Xi-Xi

摘要： Microcirculation dysfunction is regarded as one of important pathologies of senility, degeneration, immune disorder and many other diseases. Cerebral circulation insufficiency, energetic dysmetabolism, hypoxia-ischemia and metabolites accumulation in Alzheimer's disease (AD) have a close relation with microcirculation dysfunction. Here, we review microcirculation dysfunction playing an important role in hyperphosphorylation of Tau, A beta aggregation and cognitive impairment induced by accumulation of formaldehyde and D-ribose.

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