Subjects: Engineering and technical science >> Biomedical Engineering submitted time 2023-05-27
Wang, Dongping
Jin, Kai
Hu, Chenxuan
Du, Maohua
Belgaid, Yacine
Shi, Subao
Li, Jiahao
Hu, Siyi
Yu, Jun
Nathan, Arokia
Ma, Hanbin
Abstract： Digital liquid sample handling is an enabling tool for cutting-edge lifesciences research. Similar to Field Programmable Gate Arrays (FPGA) in Integrated Circuits, we present here an active-matrix thin-film electronicsbased digital microfluidics system, which will be henceforth referred to as Field Programmable Droplets Arrays (FPDA). The system contains 256 × 256 pixels in an active area of 10.65 cm2, which is capable of manipulating thousands of individually addressable liquid droplets simultaneously. By leveraging a customised TFT-based circuit design solution, it becomes possible to programmatically manipulate droplets at the pixel level. The minimum achievable droplet volume is around 0.5 nl, which is two orders of magnitude smaller than the state-of-the-art reported1. The movement of droplets can be either pre-programmed or controlled in real-time. The FPDA system shows great potential of the ubiquitous thin-film electronics technology in digital liquid handling. These efforts will make it possible to create a true programmable lab-on-a-chip device to enable great advances in life science research.
Peer Review Status:
Awaiting Review
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