Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation

Subjects: Biology >> Biophysics >> Oncology submitted time 2016-05-11

Wang, Huiru Wu, Yanhong Zhou, Chunxia Ma, Wenbo Zhang, Youhui Zhang, Shuren Wang, Huiru Wu, Yanhong Zhou, Chunxia Ma, Wenbo Zhang, Youhui Zhang, Shuren Wang, Huiru Wu, Yanhong Wang, Lin Zhou, Chunxia Ma, Wenbo Zhang, Youhui Zhang, Shuren Sun, Qing

Abstract： Granzyme M is a serine protease known to be often expressed by natural killer cells and induce target cells apoptosis in combination with perforin. However, we detected granzyme M expression in murine and human cancer cell lines and human tumor samples in our study. Granzyme M increased chemoresistance, colony-formation, cytokine secretion and invasiveness in vitro. Most importantly, granzyme M facilitated tumor growth and metastasis in vivo. Granzyme M induced the epithelial-mesenchymal transition (EMT) in cancer cells associated with STAT3 activation. Our study revealed the role of granzyme M expressed by tumor in chemoresistance, invasion, metastasis and EMT.

Peer Review Status:Awaiting Review

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