分类: 生物学 >> 生物物理学 提交时间: 2016-05-12
摘要: Rv0880 from the pathogen Mycobacterium tuberculosis is classified as a MarR family protein in the Pfam database. It consists of 143 amino acids and has an isoelectric point of 10.9. Crystals of Rv0880 belonged to space group P1, with unit-cell parameters a = 54.97, b = 69.60, c = 70.32 angstrom, alpha = 103.71, beta = 111.06, gamma = 105.83 degrees. The structure of the MarR family transcription regulator Rv0880 was solved at a resolution of 2.0 angstrom with an R-cryst and R-free of 21.2 and 24.9%, respectively. The dimeric structure resembles that of other MarR proteins, with each subunit comprising a winged helix-turn-helix domain connected to an alpha-helical dimerization domain.