Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc. submitted time 2022-11-16 Cooperative journals: 《中国全科医学》
Abstract：
Background Percutaneous coronary intervention is an effective treatment for coronary heart disease in cardiology department. In the process of coronary intervention, it faces various complex lesions, among which calcification of target vessels increases the difficulty of intervention, immediate risk of operation and the occurrence of short-term and long-term cardiovascular adverse events after operation. Early identification and evaluation of calcified lesions is of great significance to improve the success rate of surgery, reduce surgical complications, reduce cardiovascular events and improve prognosis. Objective: To explore the risk factors of calcification of target vessels in patients with coronary heart disease, and to provide evidence for early prevention, early detection and interventional therapy of coronary artery calcification.Objective To explore the risk factors of calcification of target vessels in patients with coronary heart disease, and to provide evidence for early prevention, early detection and interventional therapy of coronary artery calcification.Methods From January 2021 to December 2021, 353 patients with coronary heart disease were diagnosed by coronary angiography, of which 196 met the admission criteria. All the patients were examined by intravascular ultrasound. According to the analysis of the intravascular ultrasound imaging data of the diseased vessels, 73 cases were divided into non-calcification group (calcification index = 0) and 123 cases into calcification group, and then the calcification group was divided into low calcification index group (calcification index 0.0001-0.2166) 62 cases and high calcification index group (calcification index > 0.2166) 61 cases according to the median calcification index (M=0. 2166). Multivariate Logistic regression was used to analyze the risk factors of coronary calcification.Results There were significant differences in age, sex, prevalence of hypertension, diabetes, smoking history and thyroid disease among the three groups (P < 0.05). There were significant differences in total protein, alkaline phosphatase, glutamyltransferase, white ball ratio, triglyceride-glucose index, triglyceride, blood phosphorus and glycosylated hemoglobin among the three groups (P < 0.05). Multivariate Ordered Logistic Regression Analysis: Age (P=0. 001, OR=1. 07, 95% CI: 0.029-0.107); Alkaline phosphatase (P=0. 003, OR=1. 028, 95% CI: 0.009-0.046); Triglycerides (P=0. 015, OR=3. 174, 95% CI: 0.299-2.081); Blood phosphorus (P=0. 006, OR=13. 681, 95% CI: 0.747-4.486); Bivariate correlation (Spearman) analysis showed that age alkaline phosphatase level of triglyceride and serum phosphorus were positively correlated with coronary calcification index (P < 0.05).Conclusion Age, alkaline phosphatase, triglyceride and blood phosphorus are independent risk factors for coronary artery calcification.
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