分类： 生物学 >> 生物物理学 提交时间： 2016-05-12
Shang, Congping
Liu, Zhihui
Chen, Zijun
Shi, Yingchao
Wang, Qian
Liu, Su
Li, Dapeng
Cao, Peng
Shang, Congping
Chen, Zijun
Shi, Yingchao
摘要： The fear responses to environmental threats play a fundamental role in survival. Little is known about the neural circuits specifically processing threat-relevant sensory information in the mammalian brain. We identified parvalbumin-positive (PV+) excitatory projection neurons in mouse superior colliculus (SC) as a key neuronal subtype for detecting looming objects and triggering fear responses. These neurons, distributed predominantly in the superficial SC, divergently projected to different brain areas, including the parabigeminal nucleus (PBGN), an intermediate station leading to the amygdala. Activation of the PV+ SC-PBGN pathway triggered fear responses, induced conditioned aversion, and caused depression-related behaviors. Approximately 20% of mice subjected to the fear-conditioning paradigm developed a generalized fear memory.
分类： 心理学 >> 生理心理学 提交时间： 2021-02-09
摘要： Our current work examined the interface of thinking style and mental health at both behavioral and neuropsychological levels which describe a predisposition to psychopathology. Thirty-nine Chinese participants were divided into high and low holistic thinkers based on the triad task scores, completed the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ), and performed structural and resting-state functional magnetic resonance imaging. We found that high holistic thinkers were much less sensitive to reward than low holistic thinkers. Furthermore, their bilateral nucleus accumbens and right amygdala volumes were smaller than those of low holistic thinkers. Our integrated results showed that the relationship between holistic thinking tendency and the amygdala volume was mediated by the nucleus accumbens and the sensitivity to reward. Finally, resting-state functional connectivity results showed increased FC between left nucleus accumbens and bilateral amygdala in high holistic thinkers. The present synthetical results suggest that dialectical thinking may lead to better mental health outcomes.
分类： 生物学 >> 生物物理学 提交时间： 2016-05-12
Wei, Pengfei
Liu, Nan
Liu, Xuemei
Tang, Yongqiang
Wu, Bifeng
Zhou, Zheng
Liu, Yaohan
Li, Juan
Zhang, Yi
Wang, Liping
Wei, Pengfei
Liu, Nan
Liu, Xuemei
Tang, Yongqiang
Wu, Bifeng
Zhou, Zheng
Liu, Yaohan
Li, Juan
Zhang, Yi
Wang, Liping
摘要： The ability of animals to respond to life-threatening stimuli is essential for survival. Although vision provides one of the major sensory inputs for detecting threats across animal species, the circuitry underlying defensive responses to visual stimuli remains poorly defined. Here, we investigate the circuitry underlying innate defensive behaviours elicited by predator-like visual stimuli in mice. Our results demonstrate that neurons in the superior colliculus (SC) are essential for a variety of acute and persistent defensive responses to overhead looming stimuli. Optogenetic mapping revealed that SC projections to the lateral posterior nucleus (LP) of the thalamus, a non-canonical polymodal sensory relay, are sufficient to mimic visually evoked fear responses. In vivo electrophysiology experiments identified a di-synaptic circuit from SC through LP to the lateral amygdale (Amg), and lesions of the Amg blocked the full range of visually evoked defensive responses. Our results reveal a novel collicular-thalamic-Amg circuit important for innate defensive responses to visual threats.
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