分类： 物理学 >> 凝聚态:结构、力学和热性能 提交时间： 2017-03-26
摘要： Effects of deformed dislocation on helium retention in pure iron, including the helium atoms diffusion along the dislocation line and desorption from dislocation trapping sites, were investigated. The dislocation defect was introduced in specimens by cold-rolling, and then 5 keV helium ions were implanted into the deformed specimens. Slow positron beam technology and thermal desorption spectroscopy were used to investigate the evolution of dislocation defects and the desorption behavior of helium atoms under influence of dislocation. The behaviors of S-E, W-E and S-W plots indicate clearly that lots of helium atoms remain in the deformed specimen and helium atoms combining with dislocation change the distribution of electron density. The helium desorption plot indicates that dislocation accelerates helium desorption at 293 K-600 K and facilitates helium dissociation from HenVm (n/m=1.8) cluster.
分类： 物理学 >> 凝聚态:结构、力学和热性能 提交时间： 2017-03-26
摘要： Dislocations would be induced after plastic deformation, which might change the mechanical properties of solids. FeCrNi austenitic model alloy and its Mo-diluted alloy were cold rolled with different degree of thickness reduction. Positrons are sensitive to point defects, which are easily trapped and annihilated around the trapping sites. The mean positron lifetimes have been used to estimate the average dislocation concentration in solids. Meanwhile, the trapping efficiency μ was calculated from the lifetime results. The trapping efficiency value is estimated about 3.31×10-7 cm3s-1 for FeCrNi alloy and 3.31×10-7 cm3s-1 for Mo-diluted alloy, respectively. The increment of the hardness value during plastic deformation is related to the increase of the dislocation density and dislocation pile up in solids.
分类： 核科学技术 >> 辐射物理与技术 提交时间： 2024-06-14
摘要： The evolution of dislocation loops in austenitic steels irradiated with Fe+ is investigated using cluster dynam ics (CD) simulations by developing a CD model. The CD predictions are compared with experimental results in the literature. The number density and average diameter of the dislocation loops obtained from the CD simula tions are in good agreement with the experimental data obtained from transmission electron microscopy (TEM) observations of Fe+-irradiated Solution Annealed 304, Cold Worked 316, and HR3 austenitic steels in the liter ature. The CD simulation results demonstrate that the diffusion of in-cascade interstitial clusters plays a major role in the dislocation loop density and dislocation loop growth; in particular, for the HR3 austenitic steel, the CDmodel has verified the effect of temperature on the density and size of the dislocation loops.
分类： 物理学 >> 凝聚态:结构、力学和热性能 提交时间： 2017-03-23
摘要： The effect of isochronal annealing on vacancy-type defects in quenched FeCrNi alloys and SUS316 has been investigated by positron annihilation techniques. Vacancy-type defects gather and grow with the annealing temperature increasing to 523 K, and the vacancy-type defects annihilated gradually in FeCrNi alloys at the annealing temperature increasing. The results indicate that the addition of Mo and nonmetal elements is not the key reasons that determined the annihilated temperature of vacancy-type defects. It’s worth noting that the vacancy-type defects annihilated and dislocation-type defects formed in all sample alloys after 673 K annealing treatment. In addition, the density of defects in Mo diluted FeCrNi model alloy is lower than that in FeCrNi model alloy due to the Mo-vacancy complexes formed in Mo diluted FeCrNi model alloy. The long lifetime of vacancy-type defects in commercial stainless steel SUS316 is smaller than that in FeCrNi model alloys because the mobility of vacancy-type defects changed by nonmetal elements. In addition, vacancy-type and dislocation defects detected contribute to the S and W parameters of positron annihilation in the whole annealing treatment.
分类： 生物学 >> 生物物理学 >> 生物物理、生物化学与分子生物学 提交时间： 2016-05-12
摘要： UBXD8 is a membrane protein that mediates endoplasmic reticulum-associated protein ubiquitination and degradation by interacting with p97NCP. Recently, lipid droplet proteomic studies show the lipid droplet localization of UBXD8. Besides, UBXD8 is also involved in triglyceride metabolism. However, the molecular mechanism by which UBXD8 regulates triglyceride metabolism is still obscure. Here we knocked out UBXD8 in mouse C2C12 myoblasts by CRISPR/Cas9. We selected 2 UBXD8 knockout (KO) clone cell lines from 26 possible KO clones. UBXD8 KO did not change the lipid droplet proteins expression pattern. However, UBXD8 KO led to the accumulation of neutral lipid. Furthermore, our data show that UBXD8 KO could alleviate palmitate-induced insulin resistance and rescue palmitate-induced apoptosis which was characterized by PARP splicing. In addition, the phenotype of palmitate-induced insulin resistance and apoptosis was reappeared after overexpressing UBXD8 in UBXD8 KO cells. These data suggested that UBXD8 plays an important role in lipid metabolism and its abnormity related insulin signal and apoptosis.
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