Subjects: Chemistry >> Applied Chemistry submitted time 2020-03-05
Abstract： [Objective] Synthesis of potential neroprotective agent catalpol perpropionylated derivative (CP-6), and determination of the optimal microwav-assisted synthesis conditions. [Methods] CP-6 was synthesized by microwave-assisted synthesis (MCAS) using catalpol and propionyl anhydride as raw materials and pyridine as solvent and acid-binding agent. It was characterized by FT-IR, HRMS, NMR and assayed for neuroprotective activity by MTT method. [Results] When the molar ratio of propionic anhydride to catalpol is 18, the concentration of catalol in pyridine is 25 g/L, the reaction temperature of microwave reactor is 80 ℃, and the reaction time is 6 h, the yield of CP-6 can reach 98.51%. CP-6 has potential neroprotective activity."
Peer Review Status:
Awaiting Review
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