分类: 生物学 >> 生态学 提交时间: 2017-11-17
摘要: Chimeric antigen receptor (CAR) T-cell immunotherapies have shown unprecedented success in treating leukemia but limited clinical efficacy in solid tumors. Here, we generated 1928zT2 and m28zT2, targeting CD19 and mesothelin, respectively, by introducing the Toll/interleukin-1 receptor domain of Toll-like receptor 2 (TLR2) to 1928z and m28z. T cells expressing 1928zT2 or m28zT2 showed improved expansion, persistency and effector function against CD19+ leukemia or mesothelin+ solid tumors respectively in vitro and in vivo. In a patient with relapsed B-cell acute lymphoblastic leukemia, a single dose of 5 * 104/kg 1928zT2 T cells resulted in robust expansion and leukemia eradication and led to complete remission. Hence, our results demonstrate that TLR2 signaling can contribute to the efficacy of CAR T cells. Further clinical trials are warranted to establish the safety and efficacy of this approach.Leukemia advance online publication, 25 August 2017; doi:10.1038/leu.2017.249.
分类: 物理学 >> 普通物理:统计和量子力学,量子信息等 提交时间: 2017-05-02
摘要: Two novel conjugated donoreacceptor polymers were synthesized by combining anthracene donor and benzothiadiazole acceptor with two different side chains (conjugated and non-conjugated). Their ab- sorption spectroscopy, thermogravimetric analysis, electrochemical cyclic voltammetry, theoretical prediction, surface morphology, and photovoltaic performance were investigated. The resultant two- dimensional configuration showed good optical and electrochemical properties. By selectively intro- ducing branched conjugated side chains and non-conjugated linear side chains on the polymer back- bone, the highest occupied molecular orbital levels are low lying which results in an increased open circuit voltage for polymer solar cells. The open circuit voltage of 1.02 V in this work was among the highest value for anthracene-based polymer solar cells ever. Our results suggest a good way to regulate the molecular energy levels by selecting appropriate side chains.
分类: 天文学 >> 天文学 提交时间: 2023-02-19
摘要: The Chang'E 5 (CE-5) samples represent the youngest mare basalt ever known and provide an access into the late lunar evolution. Recent studies have revealed that CE-5 basalts are the most evolved lunar basalt, yet controversy remains over the nature of their mantle sources. Here we combine Fe and Mg isotope analyses with a comprehensive study of petrology and mineralogy on two CE-5 basalt clasts. These two clasts have a very low Mg# (~29) and show similar Mg isotope compositions with Apollo low-Ti mare basalts as well as intermediate TiO2 and Fe isotope compositions between low-Ti and high-Ti mare basalts. Fractional crystallization or evaporation during impact cannot produce such geochemical signatures which otherwise indicate a hybrid mantle source that incorporates both early- and late-stage lunar magma ocean (LMO) cumulates. Such a hybrid mantle source would be also compatible with the KREEP-like REE pattern of CE-5 basalts. Overall, our new Fe-Mg isotope data highlight the role of late LMO cumulate for the generation of young lunar volcanism.
分类: 天文学 >> 天文学 提交时间: 2023-02-19
摘要: The Chang'E 5 (CE-5) samples represent the youngest mare basalt ever known and provide an access into the late lunar evolution. Recent studies have revealed that CE-5 basalts are the most evolved lunar basalt, yet controversy remains over the nature of their mantle sources. Here we combine Fe and Mg isotope analyses with a comprehensive study of petrology and mineralogy on two CE-5 basalt clasts. These two clasts have a very low Mg# (~29) and show similar Mg isotope compositions with Apollo low-Ti mare basalts as well as intermediate TiO2 and Fe isotope compositions between low-Ti and high-Ti mare basalts. Fractional crystallization or evaporation during impact cannot produce such geochemical signatures which otherwise indicate a hybrid mantle source that incorporates both early- and late-stage lunar magma ocean (LMO) cumulates. Such a hybrid mantle source would be also compatible with the KREEP-like REE pattern of CE-5 basalts. Overall, our new Fe-Mg isotope data highlight the role of late LMO cumulate for the generation of young lunar volcanism.