分类： 医学、药学 >> 临床医学 提交时间： 2023-10-09 合作期刊: 《中国全科医学》
摘要： Background Respiratory distress syndrome（RDS）is an important cause of death in preterm infants, which needs to be constantly strengthened in clinical prevention and treatment, but the relationship of umbilical cord blood vitamin A and E levels with the development of RDS in preterm infants has been rarely reported. Objective To investigate the relationship of vitamin A and E levels in umbilical cord blood with RDS in preterm infants. Methods A total of 304 preterm infants in the Fourth Hospital of Shijiazhuang from January 2021 to January 2022 were selected and divided into the RDS group（n=120）and non-RDS group（n=184）according to the incidence of RDS. Clinical features that may be related to the occurrence of RDS in preterm infants were collected, vitamin A and E levels in umbilical cord blood were detected. Multivariate Logistic regression analysis was used to analyze the influencing factors of the occurrence and severity of RDS in preterm infants. Results The gestational age, birth weight, vitamin A and E levels in umbilical cord blood of preterm infants in the RDS group were lower than those in the non-RDS group, the proportions of newborn's Apgar score in one-minute 7, newborn's Apgar score in five-minute 7, and incidence of vitamin A deficiency were higher in the RDS group than those in the non#2; RDS group（Pwhile the incidence of vitamin A deficiency was significantly higher than cases with mild RDS（Pthat vitamin A supplementation should be applied during pregnancy to reduce the occurrence or severity of RDS in preterm infants.
分类： 地球科学 >> 地理学 提交时间： 2021-08-06 合作期刊: 《干旱区科学》
摘要： Water resources are a crucial factor that determines the health of ecosystems and socio-economic development; however, they are under threat due to climate change and human activities. The quantitative assessment of water resources using the concept of blue water and green water can improve regional water resources management. In this study, spatiotemporal distributions of blue water and green water were simulated and analyzed under scenarios of climate change and land-use changes using the Soil and Water Assessment Tool (SWAT) in Ningxia Hui Autonomous Region, Northwest China, between 2009 and 2014. Green water, a leading component of water resources, accounted for more than 69.00% of the total water resources in Ningxia. Blue water and green water showed a single peak trend on the monthly and annual scales during the study period. On the spatial scale, the southern region of Ningxia showed higher blue water and green water resources than the northern region. The spatiotemporal distribution features of blue water, green water, and green water flow had strong correlations with precipitation. Furthermore, the simulation identified the climate change in Ningxia to be more influential on blue water and green water than land-use changes. This study provides a specific scientific foundation to manage water resources in Ningxia when encountered with climate change together with human activities.
分类： 生物学 >> 生物物理学 >> 细胞生物学 提交时间： 2016-05-12
Hao, Zhenhua
Feng, Yaqin
Ma, Jing
Li, Wei
Hao, Zhenhua
Wei, Lisi
Chen, Xiaowei
Zhou, Zhuan
Chen, Liangyi
Wei, Lisi
Chen, Xiaowei
Zhou, Zhuan
Chen, Liangyi
Feng, Yaqin
Du, Wen
Li, Wei
摘要： The large dense-core vesicle (LDCV), a type of lysosome-related organelle, is involved in the secretion of hormones and neuropeptides in specialized secretory cells. The granin family is a driving force in LDCV biogenesis, but the machinery for granin sorting to this biogenesis pathway is largely unknown. The mu mutant mouse, which carries a spontaneous null mutation on the Muted gene (also known as Bloc1s5), which encodes a subunit of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), is a mouse model of Hermansky-Pudlak syndrome. Here, we found that LDCVs were enlarged in mu adrenal chromaffin cells. Chromogranin A (CgA, also known as CHGA) was increased in mu adrenals and muted-knockdown cells. The increased CgA in mu mice was likely due a failure to export this molecule out of immature LDCVs, which impairs LDCV maturation and docking. In mu chromaffin cells, the size of readily releasable pool and the vesicle release frequency were reduced. Our studies suggest that the muted protein is involved in the selective export of CgA during the biogenesis of LDCVs.
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