分类： 计算机科学 >> 计算机科学的集成理论 提交时间： 2022-11-29 合作期刊: 《数据智能（英文）》
摘要： For many government departments, uncertainty aversion is a source of barriers in the advancement of data openness. A more active response to potential risks is needed and necessitates an in-depth examination of risks related to open government data (OGD). With a cross-case study in which three cases from the United Kingdom, the United States and China are examined, this study identifies potential risks that might emerge at different stages of the lifecycle of OGD programs and constructs a taxonomy model for them. The taxonomy model distinguishes the risks from OGD from the risks to OGD, which can help government departments make better responses. Finally, risk response strategies are suggested based on the research results.
分类： 医学、药学 >> 临床医学 分类： 生物学 >> 遗传学 提交时间： 2020-03-06
Yun-Miao Guo
Jie-Rong Chen
Yan-Chun Feng
Chua, Melvin L. K.
Zeng, Yanni
Edwin Pun Hui
Allen K. C. Chan
Lin-Quan Tang
Lin Wang
Qian Cui
Hui-Qiong Han
Chun-Ling Luo
Guo-Wang Lin
Yan Liang
Yang Liu
Zhong-Lian He
Yu-Xiang Liu
Pan-Pan Wei
Chu-Jun Liu
Wan Peng
摘要： Germline polymorphisms have been linked with differential survival outcomes in cancers but have not been well studied in nasopharyngeal carcinoma (NPC). Here, two-phase association study is conducted to discover germline polymorphisms that are associated with the prognosis of NPC. The discovery phase includes two consecutive hospital cohorts of patients with NPC from Southern China. Exome-wide genotypes at 246,173 single nucleotide polymorphisms (SNPs) are determined, followed by survival analysis for each SNP under Cox proportional hazards regression model. Candidate SNP is replicated in another two independent cohorts from Southern China and Singapore. Meta-analysis of all samples (n = 5,553) confirm that the presence of rs1131636-T, located in the 3′-UTR of RPA1, confers an inferior overall survival (HR = 1.33, 95% CI = 1.20-1.47, P = 6.31 × 10-8). Bioinformatics and biological assays show that rs1131636 has regulatory effects on upstream RPA1. Functional studies further demonstrate that RPA1 promoted the growth, invasion, migration, and radioresistance of NPC cells. Additionally, miR-1253 has been identified as a suppressor for RPA1 expression, likely through regulation of its binding affinity to rs1131636 locus. Collectively, these findings provide a promising biomarker aiding in stratifying patients with poor survival, as well as a potential drug target for NPC.
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