Subjects: Astronomy >> Astrophysical processes submitted time 2023-02-19
Abstract: In this work, we collected a sample of BL Lacs, FR I and FR II(G) radio galaxies with available core and extended emissions from published works to discuss the unified schemes and estimate the Doppler factor for BL Lacs. Wilcoxon rank-sum test and Kolmogorov-Smirnov test both suggest that the probabilities for the distribution of the extended luminosity of BL Lacs and that of FR I and FR II(G) radio galaxies to be from the same parent distribution are $p_{\rm{WRS}}=0.779$ and $p_{\rm{K-S}}=0.326$, suggesting they are unified. Based on this unified schemes, we propose to estimate the Doppler factors for BL Lacs. Comparing the Doppler factor estimated by the fitting/regression method with those for the common sources in the literatures, we found a good linear correlation for common sources.
Peer Review Status:Awaiting Review
Subjects: Nuclear Science and Technology >> Engineering Technology of Fission Reactor submitted time 2023-06-18 Cooperative journals: 《Nuclear Science and Techniques》
Abstract: Nb can improve the resistance of Ni-based Hastelloy N alloy to Te-induced intergranular embrittlement. First-principles calculations are performed to research this mechanism by simulating the Ni(111) surface and the ∑5(012) grain boundary. The calculated adsorption energy suggests that Te atoms prefer diffusing along the grain boundary to forming the surface-reaction layer with Nb on surface of the Ni alloy. First-principles tensile tests show that the Nb segregation can enhance the cohesion of grain boundary. The strong Nb-Ni bonding can prevent the Te migration into the inside of the alloy. According to the Rice-Wang model, the strengthening/embrittling energies of Nb and Te are calculated, along with their mechanical and chemical components. The chemical bonds and electronic structures are analyzed to uncover the physical origin of the different effects of Te and Nb. Our work sheds lights on the effect of Nb additive on the Te-induced intergranular embrittlement in Hastelloy N alloy on the atomic and electronic level.
Subjects: Nuclear Science and Technology >> Particle Accelerator submitted time 2023-06-18 Cooperative journals: 《Nuclear Science and Techniques》
Abstract: To upgrade Hefei Light Source (HLS) Linac, eight accelerating units have been constructed to realize full-energy injection of the storage ring. Each of the units consists of two 3-m accelerators driven by one klystron. The input cavity detuning method was developed to measure and correct the phase length of the RF power distribution waveguide system. The design of the waveguide network and the principles of the detuning method are presented in this paper. After correction, the phase error between the waveguide of the two accelerators was less than �0.5�, and the maximum electron energy of Linac reached 805 MeV, which is very near the theoretical maximum value of 810 MeV. These results demonstrate that the calibration of the waveguide was successful.
Subjects: Nuclear Science and Technology >> Engineering Technology of Fission Reactor submitted time 2023-06-18 Cooperative journals: 《Nuclear Science and Techniques》
Abstract: To investigate the corrosion products of Cr in molten FLiNaK salt (46.5 mol% LiF–11.5 mol% NaF–42 mol% KF), the corrosion test of the pure metal Cr was performed in molten FLiNaK salt at 700 ℃ for 200 h. The FLiNaK salt after the corrosion test was thoroughly investigated by X-ray absorption near-edge structure spectroscopy, a transmission electron microscope, and X-ray diffraction. The results demonstrate that the predominant oxidation state of Cr in FLiNaK salt is Cr3+, and the main corrosion product in cooled FLiNaK salt is K2NaCrF6.
Subjects: Biology >> Ecology submitted time 2017-11-17
Abstract: A novel dipeptidyl peptidase IV inhibitor hit (5, IC50 = 0.86 mu M) was structurally derived from our recently disclosed preclinical candidate 4 by replacing the cyanobenzyl with a butynyl based on pharmacophore hybridization. A hit-to-lead optimization effort was then initiated to improve its potency. Most N-substituted analogs exhibited good in vitro activity, and compound 180 (IC50 = 1.55 nM) was identified to be a potent dipeptidyl peptidase IV inhibitor with a significantly improved pharmacokinetic properties (bioavailablity: 41% vs 82.9%; T-1/2: 2 h vs 4.9 h). (C) 2013 Elsevier Ltd. All rights reserved.
Peer Review Status:Awaiting Review