分类： 医学、药学 >> 基础医学 提交时间： 2017-12-07 合作期刊: 《南方医科大学学报》
摘要： 目的 研究spd1672基因在肺炎链球菌感染过程中的作用。方法 通过腹腔攻毒实验和细菌入血载量分析、细菌的粘附侵袭实验、全血杀菌实验以及相关细胞因子检测等观察 spd1672基因敲除（D39△1672菌株）后对肺炎链球菌毒力的影响。结果D39△1672菌株感染组小鼠中位生存时间和生存率显著高于野生菌株组（P<0.05），而血中细菌载量则显著低于野生菌株感染组（P<0.05）。与野生菌株比较，D39△1672菌株对A549细胞的粘附能力无明显差异，但其侵袭能力显著受损（P<0.05）。此外，D39△1672菌株对全血杀菌作用的抵抗能力亦较野生菌显著减弱（P<0.05），小鼠体内炎性细胞因子水平显著降低。结论spd1672基因与肺炎链球菌的侵袭、抗宿主能力和致炎反应等过程相关。
分类： 物理学 >> 核物理学 提交时间： 2025-04-09
Zhang, Dr. Suyalatu 张苏雅拉吐
yongshun, Dr. huang
Jiang, Dr. Wei
Fan, Dr. Ruirui
Wang, Mr. Dexin
guo, Dr. li
dandan, Dr. niu
huang, Dr. meirong 黄美容
摘要： The neutron capture cross section for ^{165}Ho was measured at the back streaming white neutron beam line (Back-n) of the China Spallation Neutron Source (CSNS) using total energy detection systems, which are composed of a set of four C_6D_6 scintillator detectors coupled with pulse height weighting techniques. The resonance parameters were extracted using the multi-level multichannel R-matrix code SAMMY, fitting the measured capture yields of the ^{165}Ho(n,\gamma) reaction in the neutron energy range below 100 eV. Subsequently, the resonance region capture cross sections were reconstructed on the basis of the obtained parameters. Furthermore, the unresolved resonance average cross section of ^{165}Ho(n,\gamma) reaction was determined relative to the standard sample ^{197}Au within the neutron energy range of 2 keV to 1 MeV. The experimental data were compared with the recommended nuclear data from the ENDF/B-VIII.0 library, as well as the calculations of the TALYS-1.9 code. The comparison indicates that the measured ^{165}Ho(n,\gamma) cross sections agree well with this data. The present results are significant for the evaluation of the ^{165}Ho neutron capture cross section, enhancing the quality of the evaluated nuclear data libraries, and providing valuable guidance for nuclear theoretical models and nuclear astrophysical studies.
分类： 物理学 >> 核物理学 提交时间： 2025-04-01
Zhang, Dr. Suyalatu 张苏雅拉吐
yongshun, Dr. huang
Jiang, Dr. Wei
Fan, Dr. Ruirui
Wang, Mr. Dexin
guo, Dr. li
dandan, Dr. niu
huang, Dr. meirong 黄美容
摘要： The neutron capture cross section for ^{165}Ho was measured at the back streaming white neutron beam line (Back-n) of the China Spallation Neutron Source (CSNS) using total energy detection systems, which are composed of a set of four C_6D_6 scintillator detectors coupled with pulse height weighting techniques. The resonance parameters were extracted using the multi-level multichannel R-matrix code SAMMY, fitting the measured capture yields of the ^{165}Ho(n,\gamma) reaction in the neutron energy range below 100 eV. Subsequently, the resonance region capture cross sections were reconstructed on the basis of the obtained parameters. Furthermore, the unresolved resonance average cross section of ^{165}Ho(n,\gamma) reaction was determined relative to the standard sample ^{197}Au within the neutron energy range of 2 keV to 1 MeV. The experimental data were compared with the recommended nuclear data from the ENDF/B-VIII.0 library, as well as the calculations of the TALYS-1.9 code. The comparison indicates that the measured ^{165}Ho(n,\gamma) cross sections agree well with this data. The present results are significant for the evaluation of the ^{165}Ho neutron capture cross section, enhancing the quality of the evaluated nuclear data libraries, and providing valuable guidance for nuclear theoretical models and nuclear astrophysical studies.
分类： 物理学 >> 核物理学 提交时间： 2025-03-24
Zhang, Dr. Suyalatu 张苏雅拉吐
yongshun, Dr. huang
Jiang, Dr. Wei
Fan, Dr. Ruirui
Wang, Mr. Dexin
guo, Dr. li
dandan, Dr. niu
huang, Dr. meirong 黄美容
摘要： The neutron capture cross section data for ^{165}Ho were measured at the Back-streaming White neutron beam line (Back-n) of China Spallation Neutron Source (CSNS) using total energy detection systems, which is comprise a set four C_6D_6 scintillator detectors coupled with pulse height weighting techniques. The resonance parameters were extracted using the multilevel, multichannel R-matrix code SAMMY, fitting the measured capture yields of the ^{165}Ho(n,\gamma) reaction in the neutron energy range below 100 eV. Subsequently, the resonance region capture cross sections were reconstructed based on the obtained parameters. Additionally, the unresolved resonance average cross section of ^{165}Ho(n,\gamma) reaction was determined relative to the standard ^{197}Au sample within the neutron energy range of 2 keV to 1 MeV. The experimental data were compared with the recommended nuclear data from the ENDF/B-VIII.0 library, as well as TALYS-1.9 code calculations. The comparison indicates that the measured ^{165}Ho(n,\gamma) cross sections are in good agreements with these data. The present results are significant for evaluating the ^{165}Ho neutron capture cross section data, enhancing the quality of evaluated nuclear data libraries, and providing valuable guidance for nuclear theoretical models and nuclear astrophysical studies.
分类： 物理学 >> 核物理学 提交时间： 2025-02-18
Zhang, Dr. Suyalatu 张苏雅拉吐
yongshun, Dr. huang
Jiang, Dr. Wei
Fan, Dr. Ruirui
Wang, Mr. Dexin
guo, Dr. li
dandan, Dr. niu
huang, Dr. meirong 黄美容
摘要： The neutron capture cross section data for ^{165}Ho were measured at the Back-streaming White neutron beam line (Back-n) of China Spallation Neutron Source (CSNS) using total energy detection systems, which is comprise a set four C_6D_6 scintillator detectors coupled with pulse height weighting techniques. The resonance parameters were extracted using the multilevel, multichannel R-matrix code SAMMY, fitting the measured capture yields of the ^{165}Ho(n,\gamma) reaction in the neutron energy range below 100 eV. Subsequently, the resonance region capture cross sections were reconstructed based on the obtained parameters. Additionally, the unresolved resonance average cross section of ^{165}Ho(n,\gamma) reaction was determined relative to the standard ^{197}Au sample within the neutron energy range of 2 keV to 1 MeV. The experimental data were compared with the recommended nuclear data from the ENDF/B-VIII.0 library, as well as TALYS-1.9 code calculations. The comparison indicates that the measured ^{165}Ho(n,\gamma) cross sections are in good agreements with these data. The present results are significant for evaluating the ^{165}Ho neutron capture cross section data, enhancing the quality of evaluated nuclear data libraries, and providing valuable guidance for nuclear theoretical models and nuclear astrophysical studies.
分类： 物理学 >> 核物理学 提交时间： 2024-01-09
摘要： 22Na(p, )23Mg 和 19Ne(, p) 22Na 是新星环境下 NeNa-MgAl 循环以及 rp-过程的两个关键反应，对于理解 新星的演化和元素核合成有重要意义。因为涉及奇 A 核 23Mg 质子分离阈上的众多共振能级，目前这两个反 应的反应率仍有较大分歧。在兰州重离子加速器国家实验室的 RIBLL1 放射性束流线上，利用 22Na+p 厚靶逆 运动学弹性散射方法对复合核23Mg 的质子共振态进行了测量，获得了质心系能量1.5～4 MeV 区间 22Na(p，p) 的激发函数，发现了复合核 23Mg 明显的质子共振态结构，为进一步的 R-矩阵理论分析奠定了基础。
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