Subjects: Biology >> Bioengineering submitted time 2018-11-17 Cooperative journals: 《中国生物工程杂志》
Abstract:合成生物学是生物学、工程学、化学和信息技术等相互交叉融合的一个新兴领域,在医学、药物、农业、材料、环境和能源等领域具有广阔的应用前景,甚至可能创造出自然界中没有的新生物,被视为生物科技领域的颠覆性技术。本研究分析了合成生物学领域主要国家和地区的相关发展战略、资助项目和政策措施,总结了合成生物学领域专利技术的发展历程,揭示了该领域的专利研发主题分布情况,综合对比分析了该领域的主要国家和主要机构的专利产出情况,以期为我国合成生物学领域的科研工作者和管理决策者提供参考数据
Subjects: Library Science,Information Science >> Information Science submitted time 2023-04-01 Cooperative journals: 《图书情报工作》
Abstract: [Purpose/significance] This paper aims to extract the tacit knowledge from the massive literatures by constructing a two-mode complex network model. [Method/process] Through the NetworkX complex network toolkit, a two-mode complex network model was constructed based on the co-occurrence relationship of any two nodes. The direct relationship between nodes and nodes was extracted by weighting the co-occurrence relationship of nodes in the network model, calculating the topology information of the network and AP clustering. The most appropriate prediction algorithm was selected by using AUC method to evaluate the four link prediction algorithms, such as AA, JC, wAA and wJC. The tacit knowledge was predicted by the most appropriate prediction algorithm from the complex networks. [Result/conclusion] The results showed that the wAA link prediction algorithm was the optimal link prediction algorithm. The two mode complex network model, indicators and method system were effective in drug target mining in the Chemical Abstracts Service database. The next step is to try in other databases or other research fields to further verify the generality and effectiveness of the model.