Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc. submitted time 2017-04-06
Abstract: It is generally difficult to predict the cell structure foamed from a binary polymer blend compared to a single polymer, as many factors in polymer blends add to the complexity of the foaming process without easy control, such as blend morphology, blend v
Peer Review Status:Awaiting Review
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc. submitted time 2017-04-06
Abstract: As the main component of the tire treads, styrene butadiene rubber (SBR) is widely used to make tire tread for cars in the rubber industry; understanding the friction and wear properties of tire tread rubber is important to improve the safety of the cars.
Peer Review Status:Awaiting Review
Subjects: Biology >> Biophysics >> Cell Biology submitted time 2016-05-12
Abstract: p53 is an important tumor suppressor and stress response mediator. Proper control of p53 level and activity is tightly associated with its function. Posttranslational modifications and the interactions with Mdm2 and Mdm4 are major mechanisms controlling p53 activity and stability. As p53 protein is short-lived and hardly detectable in unstressed situations, less is known on its basal level expression and the corresponding controlling mechanisms in vivo. In addition, it also remains obscure how p53 expression might contribute to its functional regulation. In this study, we established bacterial artificial chromosome transgenic E.coli beta-galactosidase Z gene reporter mice to monitor p53 expression in mouse tissues and identify important regulatory elements critical for the expression in vivo. We revealed preferentially high level of p53 reporter expressions in the proliferating, but not the differentiated compartments of the majority of tissues during development and tissue homeostasis. In addition, tumors as well as regenerating tissues in the p53 reporter mice also expressed high level of beta-gal. Furthermore, both the enhancer box sequence (CANNTG) in the p53 promoter and the 3' terminal untranslated region element were critical in mediating the high-level expression of the reporter. We also provided evidence that cellular myelocytomatosis oncogene was a critical player regulating p53 mRNA expression in proliferating cells and tissues. Finally, we found robust p53 activation preferentially in the proliferating compartment of mouse tissues upon DNA damage and the proliferating cells exhibited an enhanced p53 response as compared with cells in a quiescent state. Together, these results suggested a highly regulated expression pattern of p53 in the proliferating compartment controlled by both transcriptional and posttranscriptional mechanisms, and such regulated p53 expression may impose functional significance upon stress by setting up a precautionary mode in defense of cellular transformation and tumorigenesis.
Peer Review Status:Awaiting Review
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc. submitted time 2017-05-02
Abstract: Two series of poly[ester imide]s derived from bis[trimellitic acid anhydride] phenyl ester [TAHQ] and bis[[3,4-dicarboxylic anhydride] phenyl] terephthalate [PAHP], as well as poly[ether imide] s based on hydroquinone diphthalic anhydride [HQDPA], were sy
Peer Review Status:Awaiting Review
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc. submitted time 2017-05-02
Abstract: In this paper, we present a systematic investigation on the shape memory/change effect in a double network nanocomposite tough hydrogel. Water-content dependency of the response of this hydrogel to heating and wetting by water is confirmed. Since this hyd
Peer Review Status:Awaiting Review