Subjects: Biology >> Ecology submitted time 2017-11-17
Abstract: Chimeric antigen receptor (CAR) T-cell immunotherapies have shown unprecedented success in treating leukemia but limited clinical efficacy in solid tumors. Here, we generated 1928zT2 and m28zT2, targeting CD19 and mesothelin, respectively, by introducing the Toll/interleukin-1 receptor domain of Toll-like receptor 2 (TLR2) to 1928z and m28z. T cells expressing 1928zT2 or m28zT2 showed improved expansion, persistency and effector function against CD19+ leukemia or mesothelin+ solid tumors respectively in vitro and in vivo. In a patient with relapsed B-cell acute lymphoblastic leukemia, a single dose of 5 * 104/kg 1928zT2 T cells resulted in robust expansion and leukemia eradication and led to complete remission. Hence, our results demonstrate that TLR2 signaling can contribute to the efficacy of CAR T cells. Further clinical trials are warranted to establish the safety and efficacy of this approach.Leukemia advance online publication, 25 August 2017; doi:10.1038/leu.2017.249.
Peer Review Status:Awaiting Review
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc. submitted time 2017-05-02
Abstract: Two novel conjugated donor-acceptor polymers were synthesized by combining anthracene donor and benzothiadiazole acceptor with two different side chains [conjugated and non-conjugated]. Their absorption spectroscopy, thermogravimetric analysis, electroche
Peer Review Status:Awaiting Review
Subjects: Astronomy >> Astrophysical processes submitted time 2023-02-19
Abstract: The Chang'E 5 (CE-5) samples represent the youngest mare basalt ever known and provide an access into the late lunar evolution. Recent studies have revealed that CE-5 basalts are the most evolved lunar basalt, yet controversy remains over the nature of their mantle sources. Here we combine Fe and Mg isotope analyses with a comprehensive study of petrology and mineralogy on two CE-5 basalt clasts. These two clasts have a very low Mg# (~29) and show similar Mg isotope compositions with Apollo low-Ti mare basalts as well as intermediate TiO2 and Fe isotope compositions between low-Ti and high-Ti mare basalts. Fractional crystallization or evaporation during impact cannot produce such geochemical signatures which otherwise indicate a hybrid mantle source that incorporates both early- and late-stage lunar magma ocean (LMO) cumulates. Such a hybrid mantle source would be also compatible with the KREEP-like REE pattern of CE-5 basalts. Overall, our new Fe-Mg isotope data highlight the role of late LMO cumulate for the generation of young lunar volcanism.
Peer Review Status:Awaiting Review
Subjects: Astronomy >> Astrophysical processes submitted time 2023-02-19
Abstract: The Chang'E 5 (CE-5) samples represent the youngest mare basalt ever known and provide an access into the late lunar evolution. Recent studies have revealed that CE-5 basalts are the most evolved lunar basalt, yet controversy remains over the nature of their mantle sources. Here we combine Fe and Mg isotope analyses with a comprehensive study of petrology and mineralogy on two CE-5 basalt clasts. These two clasts have a very low Mg# (~29) and show similar Mg isotope compositions with Apollo low-Ti mare basalts as well as intermediate TiO2 and Fe isotope compositions between low-Ti and high-Ti mare basalts. Fractional crystallization or evaporation during impact cannot produce such geochemical signatures which otherwise indicate a hybrid mantle source that incorporates both early- and late-stage lunar magma ocean (LMO) cumulates. Such a hybrid mantle source would be also compatible with the KREEP-like REE pattern of CE-5 basalts. Overall, our new Fe-Mg isotope data highlight the role of late LMO cumulate for the generation of young lunar volcanism.
Peer Review Status:Awaiting Review