Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc. submitted time 2022-11-16 Cooperative journals: 《中国全科医学》
Abstract：
Background Hypertension and mild cognitive impairment (MCI) are ordinary health problems in the elderly. The research on the status and risk factors of MCI in the elderly population with hypertension in the community is insufficient. Objective To inquire into the prevalence of hypertension combined with mild cognitive impairment (MCI) in urban communities and analyze the possible influencing factors of its comorbidity. Methods The individuals of Hypertension aged 55 and above were selected from five urban communities in Yinchuan and Wuzhong of Ningxia. According to the presence of MCI, all participants were divided into hypertensive group with MCI and hypertensive group with normal cognitive function. Using the unconditional logistic regression to analyze the influencing factors of hypertension combined with mild cognitive impairment. Results A total of 97 (19.1%) individuals had hypertension combined with MCI, and 412 (80.9%) had hypertension with normal cognitive function. There were statistically significant differences in age stratification, gender, smoking, depressive symptom and hypertension classification between the two groups. The levels of uric acid and albumin in hypertensive group with MCI were remarkably lower than those in hypertensive group with normal cognitive function. Logistic regression analysis showed that age stratification, total depression score and hypertension classification were risk factors for hypertension with MCI, while male and albumin were independent protective factors. ROC curve showed that AUC was 0.717, P<0.001, 95%CI(0.65-0.78). Conclusion Older, and female hypertension patients with a higher degree of blood pressure, and depressive symptoms are at higher risk of MCI, the findings indicate a positive effect of screening programs and treatment of hypertension and depression on maintaining cognitive function.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-03-01 Cooperative journals: 《中国全科医学》
Abstract： Background Cardiometabolic risk factor cluster （CRFC） is a common health issue among older adults.Available studies mainly focus on the distribution of its epidemiological characteristics，but rarely assess the association between CRFC and all-cause mortality risk. Objective To explore the association between CRFC and all-cause mortality risk among community-dwelling older adults，to provide evidence for developing healthcare interventional programs for this group. Methods By use of typical sampling，this study selected 1 046 community-dwelling older adults from five urban communities in
Wuzhong and Yinchuan cities of Ningxia Hui Autonomous Region during September to November 2011. And sociodemographic questionnaire survey，health check-up，ultrasonic examination，laboratory test and CRFC assessment 〔nine cardiometabolic risk factors，including central obesity，hypercholesterolemia，hypertriglyceridemia，elevated LDL-cholesterol，decreased HDL-cholesterol，hypertension，diabetes，hyperuricemia，and nonalcoholic fatty liver disease （NAFLD）〕，were included in the multivariate Cox regression model to calculate the regression coefficient β of them after adjusting for confounders，then the coefficient of each factor was used as the weight to calculate the total risk score by adding them together were finished at baseline. The participants were followed up in 2017，2019，and 2021 by face-to-face interview coupled with searching the national death surveillance system. Log-rank test was used to compare the survival curves for all-cause mortality plotted using the KaplanMeier method for tertile groups of the total cardiometabolic risk score（P75）. The Cox regression model was employed to assess the association of all-cause mortality risk with sociodemographics，cardiometabolic risk factors，the total cardiometabolic risk score，the level of the total cardiometabolic risk score，and age. Results The participants had an average age of （66.4±6.6） years（range: 55-88） at baseline. One hundred and six death cases were identified with a ten-year accumulated mortality rate of 10.13%. The individuals in >P75 group had much lower accumulated mortality rate than the other two groups，indicating that the median survival time decreased with the increase in the total cardiometabolic risk score. Univariate Cox regression analysis showed that age，sex，living alone and education level may be associated with all-cause mortality risk （ P<0.05）. After adjusting for sociodemographic variables，the Cox regression model revealed that the cardiometabolic risk factor cluster was associated with increased risk of all-cause mortality〔 HR=3.04，95%CI（1.55，5.97）， P=0.001〕，and a dose-response effect was found that higher score was associated with an increased risk of death〔 HR=2.02，95%CI（1.16，3.50）， P=0.013〕 for > P75 when compared with risk score lower than P50）. When stratified by age group，the association only persisted among those aged 65 and over〔 HR=2.79，95%CI（1.36，5.74）， P=0.005〕；>P75 group had higher risk of death than P50 group〔 HR=1.83， 95%CI（1.02，3.28）， P=0.042〕. Conclusion The CRFC was positively associated with all-cause mortality risk among community-dwelling older adults，and higher level of clustering was associated with higher all-cause mortality risk. The findings indicate that early assessment and intervention of CRFC may play a role in improving the healthcare and reducing the risk of death in this population .
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2022-10-13 Cooperative journals: 《中国全科医学》
Abstract： Objective To explore the association between cardiometabolic risk factor cluster and all-cause mortality risk among community older adults, and to provide evidence for developing interventional programs. Methods A cohort study was conducted from September 2011 to July 2021, a total of 1046 community dwellings aged 55 and above were enrolled from five communities at Ningxia Hui Autonomous Region. The Cox regression model was employed to identify the predictors of the risk of all-cause death. Results 106 death cases were identified with a ten-year accumulated mortality rate of 10.13%. Individuals with older age（HR=5.10，P=0.001）, male（HR=1.97，P=0.006）, living alone（HR=1.61，P=0.030）, and less educated（HR=1.72，P=0.011） had a higher risk of death than their counterparts. Under the control of sociodemographic variables, the Cox regression model revealed that the cardiometabolic risk factor cluster was associated with increased risk of all-cause death(HR=3.04, P=0.001), and a dose-response effect was found that higher score associated with an increased risk of death (HR=2.02 for risk score higher than P75when compared with risk score lower than P50). Stratified by age group, the association only persisted among those aged 65 and over (HR=1.83, P=0.042). Conclusion The cluster of cardiometabolic risk factors is an independent predictor of all-cause mortality among older adults, the findings indicate that the identification of cardiovascular metabolic risk factors and early intervention may reduce the risk of death and prolong the life span of older adults.
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