摘要: A growing interest in producing and sharing computable biomedical knowledge artifacts (CBKs) is
increasing the demand for repositories that validate, catalog, and provide shared access to CBKs. However,
there is a lack of evidence on how best to manage and sustain CBK repositories. In this paper, we present the
results of interviews with several pioneering CBK repository owners. These interviews were informed by the
Trusted Repositories Audit and Certification (TRAC) framework. Insights gained from these interviews suggest
that the organizations operating CBK repositories are somewhat new, that their initial approaches to repository
governance are informal, and that achieving economic sustainability for their CBK repositories is a major
challenge. To enable a learning health system to make better use of its data intelligence, future approaches
to CBK repository management will require enhanced governance and closer adherence to best practice
frameworks to meet the needs of myriad biomedical science and health communities. More effort is needed
to find sustainable funding models for accessible CBK artifact collections.