分类： 管理学 >> 管理学其他学科 提交时间： 2022-11-25 合作期刊: 《Economics & Management Review》
摘要：Under the background of normalized epidemic prevention and control,Enhancing the coordination ability within maternal and child health care institutions can effectively reduce the losses caused by COVID - 19 outbreak and ensure the diagnosis and treatment activity in hospital orderly. This paper introduces the theory of collaboration governance and constructs the internal collaboration system of "policy collaboration, information collaboration, relationship collaboration and technology collaboration", which provides reference for institutions to improve emergency management ability.
分类： 医学、药学 >> 临床医学 分类： 生物学 >> 遗传学 提交时间： 2020-03-06
Yun-Miao Guo
Jie-Rong Chen
Yan-Chun Feng
Chua, Melvin L. K.
Zeng, Yanni
Edwin Pun Hui
Allen K. C. Chan
Lin-Quan Tang
Lin Wang
Qian Cui
Hui-Qiong Han
Chun-Ling Luo
Guo-Wang Lin
Yan Liang
Yang Liu
Zhong-Lian He
Yu-Xiang Liu
Pan-Pan Wei
Chu-Jun Liu
Wan Peng
摘要：Germline polymorphisms have been linked with differential survival outcomes in cancers but have not been well studied in nasopharyngeal carcinoma (NPC). Here, two-phase association study is conducted to discover germline polymorphisms that are associated with the prognosis of NPC. The discovery phase includes two consecutive hospital cohorts of patients with NPC from Southern China. Exome-wide genotypes at 246,173 single nucleotide polymorphisms (SNPs) are determined, followed by survival analysis for each SNP under Cox proportional hazards regression model. Candidate SNP is replicated in another two independent cohorts from Southern China and Singapore. Meta-analysis of all samples (n = 5,553) confirm that the presence of rs1131636-T, located in the 3′-UTR of RPA1, confers an inferior overall survival (HR = 1.33, 95% CI = 1.20-1.47, P = 6.31 × 10-8). Bioinformatics and biological assays show that rs1131636 has regulatory effects on upstream RPA1. Functional studies further demonstrate that RPA1 promoted the growth, invasion, migration, and radioresistance of NPC cells. Additionally, miR-1253 has been identified as a suppressor for RPA1 expression, likely through regulation of its binding affinity to rs1131636 locus. Collectively, these findings provide a promising biomarker aiding in stratifying patients with poor survival, as well as a potential drug target for NPC.
分类： 医学、药学 >> 药学 提交时间： 2020-02-23
Hua Li
Canrong Wu
Yueying Yang
Yang Liu
Peng Zhang
Yali Wang
Qiqi Wang
Yang Xu
Mingxue Li
Mengzhu Zheng
Lixia Chen
摘要：A novel coronavirus (SARS-CoV-2) infectious disease has broken out in Wuhan, Hubei Province since December 2019, and spread rapidly from Wuhan to other areas, which has been listed as an international concerning public health emergency. We compared the Spike proteins from four sources, SARS-CoV-2, SARS-CoV, MERS-CoV and Bat-CoVRaTG13, and found that the SARS-CoV-2 virus sequence had redundant PRRA sequences. Through a series of analyses, we propose the reason why SARS-CoV-2is more infectious than other coronaviruses. And through structure based virtual ligand screening, we foundpotentialfurin inhibitors, which might be used in the treatment of new coronary pneumonia.
分类： 物理学 >> 普通物理:统计和量子力学,量子信息等 提交时间： 2017-11-10
Hong Li
Si-Yu Li
Yang Liu
Yong-Ping Li
Yifu Cai
Mingzhe Li
Gong-Bo
Zhao
Cong-Zhan Liu
Zheng-Wei Li
He Xu
Di Wu
Yong-Jie Zhang
Zu-Hui
Fan
Yong-Qiang Yao
Chao-Lin Kuo
Fang-Jun Lu
Xinmin Zhang
摘要：In this paper, we will give a general introduction to the project of Ali CMB Polarization Tele-scope (AliCPT), which is a Sino-US joint project led by the Institute of High Energy Physics (IHEP) and has involved many di erent institutes in China. It is the rst ground-based cosmic microwave background (CMB) polarization experiment in China and an integral part of China's Gravitational Waves Program. The main scienti c goal of AliCPT project is to probe the primor-dial gravitational waves (PGWs) originated from the very early Universe. The AliCPT project includes two stages. The rst stage referred to as AliCPT-1, is to build a telescope in the Ali region of Tibet with an altitude of 5,250 meters. Once completed, it will be the worldwide highest ground-based CMB observatory and open a new window for probing PGWs in northern hemisphere. AliCPT-1 telescope is designed to have about 7,000 TES detectors at 90GHz and 150GHz. The second stage is to have a more sensitive telescope (AliCPT-2) with the number of detectors more than 20,000. Our simulations show that AliCPT will improve the current constraint on the tensor-to-scalar ratio r by one order of magnitude with 3 years' observation. Besides the PGWs, the AliCPT will also enable a precise measurement on the CMB rotation angle and provide a precise test on the CPT symmetry. We show 3 years' observation will improve the current limit by two order of magnitude.
分类： 物理学 >> 核物理学 提交时间： 2016-09-19
摘要：The study of reionization history plays an important role in understanding the evolution of our universe. It is commonly believed that the intergalactic medium (IGM) in our universe are fully ionized today, however the reionizing process remains to be mysterious. A simple instantaneous reionization process is usually adopted in modern cosmology without direct observational evidence. However, the history of ionization fraction, xe(z) will influence cosmic microwave background (CMB) observables and constraints on optical depth τ. With the mocked future data sets based on featured reionization model, we find the bias on τ introduced by instantaneous model can not be neglected. In this paper, we study the cosmic reionization history in a model independent way, the so called principle component analysis (PCA) method, and reconstruct xe(z) at different redshift z with the data sets of Planck, WMAP 9 years temperature and polarization power spectra, combining with the baryon acoustic oscillation (BAO) from galaxy survey and type Ia supernovae (SN) Union 2.1 sample respectively. The results show that reconstructed xe(z) is consistent with instantaneous behavior, however, there exists slight deviation from this behavior at some epoch. With PCA method, after abandoning the noisy modes, we get stronger constraints, and the hints for featured xe(z) evolution could become a little more obvious.
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