分类： 地球科学 >> 地质学 提交时间： 2021-12-01
摘要： Indochina developed continental-scale shear zones that record Cenozoic tectonic processes in SE Asia. Previous extrusion models that linked these shear zones with the northward indentation of the Indian continent, conflict with distributed conjugate strike-slip pairs and post-Oligocene rotation in Indochina. This paper presents evidence of coeval shearing along the Mogok-Shan Scarp fault in Myanmar, the western boundary of the Indochina block, previously proposed as a product of northward indentation of Indian Plate. The Kyanigan quarry along the northern Mogok-Shan Scarp fault exposes paragneiss, marble and quartzite schist. ‘σ’ structures, cored with garnet, in paragneiss record right-lateral shear sense, consistent with ‘σ’ and ’δ’ structures in L-tectonites in the Moulmein granitic mylonite to the south. U-Pb ages of metamorphic zircons of paragneiss and a biotite 39Ar-40Ar age of quartzite schist constrain deformation in the Kyanigan quarry to 33-21 Ma; a biotite 39Ar-40Ar age of mylonite at Moulmein is 26 Ma. These ages demonstrate Oligocene right-lateral shearing along the Mogok-Shan Scarp fault, coeval with other shear zones in Indochina. These Oligocene shear zones and strike-slip faults are conjugate structures recording left-lateral shear sense on NW-striking and right-lateral shear sense on N-S to NE-striking features. After restoration of ~80° clockwise rotation, the Oligocene conjugate strike-slip pairs in Indochina reflect approximate N-S-directed shortening, corresponding to northward subduction of the Indian ocean. This suggests that continental-scale intra-continental shearing may have been triggered by syn-subduction compression in SE Asia.
分类： 生物学 >> 生物化学 提交时间： 2021-12-01
摘要： 摘要： [目的]尿液蛋白质组能够灵敏的反映机体的生理变化，可以为炎症引起的结直肠癌的发展提供一定线索。 [方法]本研究使用液相色谱联用质谱（LC-MS/MS），对利用AOM/DSS诱导炎症引起的结直肠癌小鼠模型的尿液差异蛋白进行筛选并进行生物学通路的分析，从生物学通路层面去寻找规律，探究小鼠炎癌模型在结直肠癌的发展中的变化过程。 [结果]（1）尿液蛋白质组的变化能够反映实验小鼠的病理生理变化。所有实验小鼠差异蛋白富集到被报道过的且与炎症和肿瘤相关的共有生物学通路有：急性期反应、细胞黏附、天然免疫反应、蛋白激酶B信号的正调控、B细胞活化正调控、糖代谢的相关通路，特别是免疫相关的反应伴随始终。（2）实验小鼠的疾病进展不同，进展不同阶段的小鼠尿液蛋白质组表现不同。本研究运用的单只小鼠独立分析的研究方法能为炎癌模型的小鼠疾病进程提供线索，同时也为未来个性化、精准化疾病分析的方法提供借鉴。
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