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1. chinaXiv:201711.00278 [pdf]

PRN: a preprint service for catalyzing R-fMRI and neuroscience related studies

Chao-Ganyan; Qingyang Li; Lei Gao
Subjects: Psychology >> Experimental Psychology

Sharing drafts of scientific manuscripts on preprint hosting services for early exposure and pre-publication feedback is a well-accepted practice in fields such as physics, astronomy, or mathematics. The field of neuroscience, however, has yet to adopt the preprint model. A reason for this reluctance might partly be the lack of central preprint services for the field of neuroscience. To address this issue, we announce the launch of Preprints of the R-fMRI Network (PRN), a community funded preprint hosting service. PRN provides free-submission and free hosting of manuscripts for resting state functional magnetic resonance imaging (R-fMRI) and neuroscience related studies. Submissions will be peer viewed and receive feedback from readers and a panel of invited consultants of the R-fMRI Network. All manuscripts and feedback will be freely available online with citable permanent URL for open-access. The goal of PRN is to supplement the “peer reviewed” journal publication system – by more rapidly communicating the latest research achievements throughout the world. We hope PRN will help the field to embrace the preprint model and thus further accelerate R-fMRI and neuroscience related studies, eventually enhancing human mental health.

submitted time 2017-11-06 Hits4391Downloads1456 Comment 0

2. chinaXiv:201711.00275 [pdf]

Reliability of sleep deprivation-associated spontaneous brain activity and behavior

Lei Gao; Lijun Bai; Yuchen Zhang; Xi-jian Dai; Rana Netra; Youjiang Min; Fuqing燴hou; Honghan Gong; Ming Zhang; Yijun Liu
Subjects: Psychology >> Applied Psychology

Recent studies have indicated that sleep deprivation (SD) alters intrinsic low-frequency connectivity in the resting brain, mainly focusing on the default mode network (DMN) and its anticorrelated network (ACN). These networks hold key functions in segregating internally and externally directed awareness. However, far less attention has been paid to investigation of the altered amplitude of these low-frequency fluctuations (ALFF) at the whole-brain level and more importantly by what extent the sleep-deprived resting brain pattern can be reproducible and predict individual behavioral performance. The aim of this study was to characterize more clearly the influence of sleep on the whole brain level of ALFF changes and its relation with the performance of a lexical decision task in the sleep deprivation. Sixteen healthy participants underwent fMRI three times: once after a normal night of sleep in the rested wakefulness (RW) state and two following approximately 24 h of total SD separated by an interval of two weeks (SD1 and SD2). Our behavioral results showed that sleep stabilizes performance whereas two sleep deprivation even at an interval of two weeks consistently deteriorates it. Sleep deprivation attenuated the ALFF mainly in the bilateral orbitofrontal cortex (OFC), bilateral dorsolateral prefrontal cortex (DLPFC) and right inferior parietal lobule (IPL). By contrast, the enhanced ALFF emerged in the left sensorimotor cortex (SMA), visual cortex and left fusiform gyrus. Conjunction analysis of SD1 and SD2 versus the control maps and voxel-wise ICC analysis revealed that these SD induced ALFF changes showed a significantly high reliability (ICC>0.5). Particularly, the attenuation of the right IPL presents a significant negative relation with the behavior performance and can be reproducible for two SD at an interval of two weeks. Our results suggest that ALFF is a stable measure in study of SD, and the right IPL may represent a stable biomarker that responds to sleep loss.

submitted time 2017-11-06 Hits6394Downloads1354 Comment 0

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