分类： 生物学 >> 生物物理学 分类： 化学 >> 物理化学 分类： 生物学 >> 生物物理学 提交时间： 2024-04-16
摘要： Transcription factor (TF) are proteins that regulates the transcription of genetic information from DNA to messenger RNA by binding to a specific DNA sequence.Nucleic acid-protein interactions are crucial in regulating transcription in biological systems. This work presents a quick and convenient method for constructing tight-binding models and offers physical insights into the electronic structure properties of transcription factor complexes and DNA motifs. The tight binding Hamiltonian parameters are generated using the random forest regression algorithm, which reproduces the given ab-initiolevel calculations with reasonable accuracy. We present a library of residue-level parameters derived from extensive electronic structure calculations over various possible combinations of nucleobases and amino acid side chains from high-quality DNA-protein complex structures. As an example, our approach can reasonably generate the subtle electronic structure details for the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta within a few seconds on a laptop. This method potentially enhances our understanding of the electronic structure variationsof gene-protein interaction complexes, even those involving dozens of proteins and genes. We hope this study offers a powerful tool for analyzing transcription regulation mechanisms at an electronic structural level.
分类： 天文学 >> 天文学史 分类： 天文学 >> 天文仪器与技术 提交时间： 2024-04-10
摘要： 中国古代保留着丰富的天文观测记录，其中尤为宝贵的是大量实测的恒星观测数据。然而，确定这些观测数据的年代是一个相当复杂的问题。本文以宋元时代的两组观测数据为基础，运用广义霍夫变换的技术手段对数据进行计算和分析。我们成功地获得了对恒星观测年代的较为准确的估算结果。这一方法为未来分析更多古代天文星表数据提供了新的途径和视角。
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： Correlated red noise recently reported from pulsar timing observations may be an indication of stochastic gravitational waves emitted by cosmic strings that formed during a primordial phase transition near the Grand Unification energy scale. Unfortunately, known probes of cosmic strings, namely the Cosmic Microwave Background anisotropies and string lensing of extragalactic galaxies, are not sensitive enough for low string tensions of $G\mu = 10^{-10}-10^{-7}$ that are needed to explain this putative signal. We show that strong gravitational lensing of Fast Radio Bursts (FRBs) by cosmic strings is a potentially unambiguous avenue to probe that range of string tension values. The image pair of string lensing are expected to have identical magnification factor and parity, and have a typical time delay of $\sim 10^2\,\,(G\,\mu/10^{-8})^2$ seconds. The unique spectral fingerprint of each FRB, as well as the possibility to detect correlations in the time series of the electric field of the radio waves, will enable verification of the string lensing interpretation. Very-Long-Baseline Interferometry (VLBI) observations can spatially resolve the image pair and provide a lower bound on the string tension based on the image separation. We calculate the FRB lensing rate as a function of FRB detection number for several different models of the FRB redshift distribution. We find that a survey detecting $\sim 10^5$ FRBs, in line with estimates for the detection rate of the forthcoming survey CHORD, can uncover a strong lensing event for a string tension of $G\mu \simeq 10^{-7}$. Larger FRB surveys, such as Phase 2 of the Square Kilometre Array (SKA), have the potential to significantly improve the sensitivity on the string tension to $G\mu \simeq 10^{-9}$.
分类： 图书馆学、情报学 >> 情报学 提交时间： 2024-04-16
摘要： 数字经济时代最特殊的一种资产就是数据，数据作为生产要素和企业资产，已成为新时代我国的生产核心要素，是数字经济的核心引擎，数据要素不仅推动传统生产要素革命性聚变与裂变进而产生倍增效应，而且提高了传统要素的配置效率，驱动经济加快创新发展。然而数据流通交易作为数据要素市场化配置的关键环节却缺乏有效实践，本文从信息管理的角度出发，以上海数据交易所为例，从制度保障、基础设施建设以及平台运营机制这三个方面为企业数据资产化的实现路径提供一个样本参考，通过这一研究，旨在提高企业更加重视数据要素的意识，重视数据资产的价值挖掘和使用，致力于有效实现资源统筹优化，从而有效推动我国经济高质量发展。
分类： 生物学 >> 植物学 >> 应用植物学 提交时间： 2024-04-17 合作期刊: 《广西植物》
摘要： 膨胀素（expansin，EXP）通过调控细胞壁的松弛在植物应对环境胁迫过程中起着 重要作用。为研究EXP 基因在大豆应对非生物胁迫过程中的作用，对大豆中的两个EXP 基 因（GmEXPB5 和GmEXPB7）及其蛋白序列进行生物信息学分析，通过实时荧光定量PCR （qRT-PCR）检测基因表达量。结果表明：(1) GmEXPB5 和GmEXPB7 分别位于大豆第10 和12 号染色体上，编码的蛋白序列长度分别为272 和267 个氨基酸。GmEXPB5 蛋白分子 量为29.07 kD，理论等电点为7.51；GmEXPB7 蛋白分子量为29.09 kD，理论等电点为8.66。 GmEXPB5 和GmEXPB7 均为稳定的亲水蛋白且定位于细胞壁中。GmEXPB5 和GmEXPB7 蛋白均含有一段信号肽序列和一个保守的DPBB_1 结构域。(2) GmEXPB5 蛋白与鹰嘴豆 CaEXPB15 蛋白亲缘关系最近，GmEXPB7 蛋白与密花豆、赤豆和豇豆的EXPB3 蛋白有着 较近的亲缘关系。(3) GmEXPB5 和GmEXPB7 在大豆根、茎和叶中均表达且它们在根和叶中 的表达量均显著高于茎中的表达量。(4) GmEXPB5 和GmEXPB7 在大豆幼苗中可以响应盐、 干旱和低温胁迫。(5) GmEXPB5 启动子区域含有两种与逆境相关的顺式作用元件（ABRE 和 ARE）；GmEXPB7 启动子区域含有五种与逆境相关的顺式作用元件（ABRE、ARE、 CGTCA-motif、TC-rich repeats 和MBS）。上述结果表明，GmEXPB5 和GmEXPB7 能够参 与大豆对非生物胁迫的应答。
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： We measure for the first time the outermost edges of the Milky Way (MW) halo in terms of the depletion and turnaround radii. The inner depletion radius, $r_\mathrm{id}$, identified at the location of maximum infall velocity, separates a growing halo from the draining environment, while the turnaround radius, $r_\mathrm{ta}$, marks the outermost edge of infalling material towards the halo, both of which are located well outside the virial radius. Using the motions of nearby dwarf galaxies within $3\mathrm{Mpc}$, we obtain a marginal detection of the infall zone around the MW with a maximum velocity of $v_\mathrm{inf, max}=-46_{-39}^{+24}\mathrm{km s^{-1}}$. This enables us to measure $r_\mathrm{id}=559\pm 107 \mathrm{kpc}$ and $r_\mathrm{ta}=839\pm 121 \mathrm{kpc}$. The measured depletion radius is about 1.5 times the MW virial radius ($R_\mathrm{200m}$) measured from internal dynamics. Compared with halos in the cosmological simulation Illustris TNG100, the factor 1.5 is consistent with that of halos with similar masses and dynamical environments to the MW but slightly smaller than typical values of Local Group analogs, potentially indicating the unique evolution history of the MW. These measurements of halo edges directly quantify the ongoing evolution of the MW outer halo and provide constraints on the current dynamical state of the MW that are independent from internal dynamics.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： The Solar System's orbital structure is thought to have been sculpted by an episode of dynamical instability among the giant planets. However, the instability trigger and timing have not been clearly established. Hydrodynamical modeling has shown that while the Sun's gaseous protoplanetary disk was present the giant planets migrated into a compact orbital configuration in a chain of resonances. Here we use dynamical simulations to show that the giant planets' instability was likely triggered by the dispersal of the gaseous disk. As the disk evaporated from the inside-out, its inner edge swept successively across and dynamically perturbed each planet's orbit in turn. The associated orbital shift caused a dynamical compression of the exterior part of the system, ultimately triggering instability. The final orbits of our simulated systems match those of the Solar System for a viable range of astrophysical parameters. The giant planet instability therefore took place as the gaseous disk dissipated, constrained by astronomical observations to be a few to ten million years after the birth of the Solar System. Terrestrial planet formation would not complete until after such an early giant planet instability; the growing terrestrial planets may even have been sculpted by its perturbations, explaining the small mass of Mars relative to Earth.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： A general covariant local field theory of the holographic dark energy model is presented. It turns out the low energy effective theory of the holographic dark energy is the massive gravity theory whose graviton has 3 polarisations, including one scalar mode and two tensor modes. The Compton wavelength is the size of the future event horizon of the universe. The UV-IR correspondence in the holographic dark energy model stems from the scalar graviton's strong coupling at the energy scale that marks the breaking down of the effective field theory.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： Thermoelastic loss is one of the main energy dissipation mechanisms in resonant systems. A careful analysis of the thermoelastic loss is critical to design low-noise resonators for high-precision applications, such as gravitational-wave detectors. This paper presents an analytical solution to the thermoelastic loss in multimaterial coated finite substrates with realistic assumptions on the model structure and the elastic fields. The mechanism responsible for thermoelastic loss is taken as a function of material properties, operating temperature and frequency, and other design parameters. We calculate the thermoelastic loss for specific applications over a wide range of frequencies (1 Hz to 10 GHz) and temperatures (1 K to 300 K), and for a variety of substrate and coating materials. The result is relevant for gravitational-wave detectors and for experiments sensitive to mechanical dissipation.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： Potential features in the primordial power spectrum have been searched for in galaxy surveys in recent years since these features can assist in understanding the nature of inflation. The null detection to date suggests that any such features should be fairly weak, and next-generation galaxy surveys, with their unprecedented sizes and precisions, are in a position to place stronger constraints than before. However, even if such primordial features once existed in the early Universe, they would have been significantly damped in the nonlinear regime at low redshift due to structure formation, which makes them difficult to be directly detected in real observations. A potential way to tackle this challenge for probing the features is to undo the cosmological evolution, i.e., using reconstruction to obtain an approximate linear density field. By employing a set of N-body simulations, here we show that a recently-proposed nonlinear reconstruction algorithm can effectively retrieve damped oscillatory features from halo catalogues and improve the accuracy of the measurement of feature parameters (assuming that such primordial features do exist). We do a Fisher analysis to forecast how nonlinear reconstruction affects the constraining power, and find that it can lead to significantly more robust constraints on the feature amplitude for a DESI-like survey. Comparing nonlinear reconstruction with other ways of improving constraints, such as increasing the survey volume and range of scales, this shows that it is possible to achieve what the latter do, but at a lower cost.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： Building accurate and predictive models of the underlying mechanisms of celestial motion has inspired fundamental developments in theoretical physics. Candidate theories seek to explain observations and predict future positions of planets, stars, and other astronomical bodies as faithfully as possible. We use a data-driven learning approach, extending that developed in Lu et al. ($2019$) and extended in Zhong et al. ($2020$), to a derive stable and accurate model for the motion of celestial bodies in our Solar System. Our model is based on a collective dynamics framework, and is learned from the NASA Jet Propulsion Lab's development ephemerides. By modeling the major astronomical bodies in the Solar System as pairwise interacting agents, our learned model generate extremely accurate dynamics that preserve not only intrinsic geometric properties of the orbits, but also highly sensitive features of the dynamics, such as perihelion precession rates. Our learned model can provide a unified explanation to the observation data, especially in terms of reproducing the perihelion precession of Mars, Mercury, and the Moon. Moreover, Our model outperforms Newton's Law of Universal Gravitation in all cases and performs similarly to, and exceeds on the Moon, the Einstein-Infeld-Hoffman equations derived from Einstein's theory of general relativity.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： Presolar grains are microscopic dust grains that formed in the stellar winds or explosions of ancient stars that died before the formation of the solar system. The majority (~90% in number) of presolar silicon carbide (SiC) grains, including types mainstream (MS), Y, and Z, came from low-mass C-rich asymptotic giant branch (AGB) stars, which is supported by the ubiquitous presence of SiC dust observed in the circumstellar envelope of AGB stars and the signatures of slow neutron-capture process preserved in these grains. Here, we review the status of isotope studies of presolar AGB SiC grains with an emphasis on heavy-element isotopes and highlight the importance of presolar grain studies for nuclear astrophysics. We discuss the sensitives of different types of nuclei to varying AGB stellar parameters and how their abundances in presolar AGB SiC grains can be used to provide independent, detailed constraints on stellar parameters, including 13C formation, stellar temperature, and nuclear reaction rates.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： Simple climate models have been around for more than a century but have recently come back into fashion: they are useful for explaining global warming and the habitability of extrasolar planets. The Climate App (https://www.climateapp.ca) is an interactive web-based application that describes the radiative transfer governing planetary climate. The App is currently available in French and English and is suitable for teaching high-school through college students, or public outreach. The beginner version can be used to explore the greenhouse effect and planetary albedo, sufficient for explaining anthropogenic climate change, the Faint Young Sun Paradox, the habitability of TRAPPIST planets and other simple scenarios. There is also an advanced option with more atmospheric layers and incorporating the absorption and scattering of shortwave radiation for students and educators wishing a deeper dive into atmospheric radiative transfer. A number of pedagogical activities are being beta tested and rolled out.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： The Messenger Interface Monte-Carlo Mappings V (M^3) is a photoionization code adopting the fully self-consistent Monte-Carlo radiative transfer technique, which presents a major advance over previous photoionization models with simple geometries. M^3 is designed for modeling nebulae in arbitrary three-dimensional geometries. In this paper, we describe the Monte-Carlo radiative transfer technique and the microphysics implemented in M^3, including the photoionization, collisional ionization, the free-free and free-bound recombination, and two-photon radiation. We put M^3 through the Lexington/Meudon benchmarks to test the reliability of the new code. We apply M^3 to three HII region models with fiducial geometries, demonstrating that M^3 is capable of dealing with nebulae with complex geometries. M^3 is a promising tool for understanding emission-line behavior in the era of SDSS-V/LVM and JWST, which will provide high-quality data of spatially-resolved nearby HII regions and highly turbulent local and high-redshift HII regions.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： There is long research interest in electron-induced reactions of halogenated molecules. It has been two decades since the cosmic-ray (CR) driven electron-induced reaction (CRE) mechanism for the ozone hole formation was proposed. The derived CRE equation with stratospheric equivalent chlorine level and CR intensity as only two variables has well reproduced the observed data of stratospheric O3 and temperatures over the past 40 years. The CRE predictions of 11-year cyclic variations of the Antarctic O3 hole and associated stratospheric cooling have also been well confirmed. Measured altitude profiles of ozone and temperatures in Antarctic ozone holes provide convincing fingerprints of the CRE mechanism. A quantitative estimate indicates that the CRE-produced Cl atoms could completely deplete or even over-kill ozone in the CR-peak polar stratospheric region, consistent with observed altitude profiles of severest Antarctic ozone holes. After removing the natural CR effect, the hidden recovery in the Antarctic O3 hole since around 1995 is clearly discovered, while the recovery of O3 loss at mid-latitudes is being delayed by >=10 years. These results have provided strong evidence of the CRE mechanism. If the CR intensity keeps the current rising trend, the Antarctic O3 hole will return to the 1980 level by around 2060, while the returning of the O3 layer at mid-latitudes to the 1980 level will largely be delayed or will not even occur by the end of this century. The results strongly indicate that the CRE mechanism must be considered as a key factor in evaluating the O3 hole.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： We identify hierarchical structures in the Vela OB2 complex and the cluster pair Collinder 135 and UBC 7 with Gaia EDR3 using the neural network machine learning algorithm StarGO. Five second-level substructures are disentangled in Vela OB2, which are referred to as Huluwa 1 (Gamma Velorum), Huluwa 2, Huluwa 3, Huluwa 4 and Huluwa 5. For the first time, Collinder 135 and UBC 7 are simultaneously identified as constituent clusters of the pair with minimal manual intervention. We propose an alternative scenario in which Huluwa 1-5 have originated from sequential star formation. The older clusters Huluwa 1-3 with an age of 10-22 Myr, generated stellar feedback to cause turbulence that fostered the formation of the younger-generation Huluwa 4-5 (7-20 Myr). A supernova explosion located inside the Vela IRAS shell quenched star formation in Huluwa 4-5 and rapidly expelled the remaining gas from the clusters. This resulted in global mass stratification across the shell, which is confirmed by the regression discontinuity method. The stellar mass in the lower rim of the shell is $0.32\pm0.14$ $\rm M_\odot$ higher than in the upper rim. Local, cluster-scale mass segregation is observed in the lowest-mass cluster Huluwa 5. Huluwa 1-5 (in Vela OB2) are experiencing significant expansion, while the cluster pair suffers from moderate expansion. The velocity dispersions suggest that all five groups (including Huluwa 1A and Huluwa 1B) in Vela OB2 and the cluster pair are supervirial and are undergoing disruption, and also that Huluwa 1A and Huluwa 1B may be a coeval young cluster pair. N-body simulations predict that Huluwa 1-5 in Vela OB2 and the cluster pair will continue to expand in the future 100 Myr and eventually dissolve.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： The exchange of a pair of neutrinos between two objects, seperated by a distance $r$, leads to a long-range effective potential proportional to $1/r_{}^5$, assuming massless neutrinos and four-fermion contact interactions. In this paper, we investigate how this known form of neutrino-mediated potentials might be altered if the distance $r$ is sufficiently short, corresponding to a sufficiently large momentum transfer which could invalidate the contact interactions. We consider two possible scenarios to open up the contact interactions by introducing a $t$-channel or an $s$-channel mediator. We derive a general formula that is valid to describe the potential in all regimes as long as the external particles remain non-relativistic. In both scenarios, the potential decreases as $1/r_{}^5$ in the long-range limit as expected. In the short-range limit, the $t$-channel potential exhibits the Coulomb-like behavior (i.e. proportional to $1/r$), while the $s$-channel potential exhibits $1/r_{}^4$ and $1/r_{}^2$ behaviors.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： We show that the gravitational wave signals from primordial black hole (PBH) binaries at high redshift can be detected. The detectability of PBH binaries is enhanced by redshift bias and more PBH binaries at high redshift. The initial clustering of PBHs is also included and enhances the effectively detectable mass ranges of PBHs at high redshift. Future observations on the gravitational wave at high redshift by space-based detectors such as LISA and SKA can constrain the fraction of PBHs in dark matter and PBHs initial distribution.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
Baiyang Bi
Miquel Barcelo
Christian Bauer
Faical Ait Benkhali
Jacqueline Catalano
Sebastian Diebold
Christian Föhr
Stefan Funk
Gianluca Giavitto
German Hermann
Jim Hinton
Ira Jung-Richardt
Oleg Kalekin
Ruben Kankanyan
Thomas Kihm
Fabian Leuschner
Marc Pfeifer
Gerd Pühlhofer
Olaf Reimer
Simon Sailer
摘要： In October 2019, the central 28 m telescope of the H.E.S.S. experiment has been upgraded with a new camera. The camera is based on the FlashCam design which has been developed in view of a possible future implementation in the Medium-Sized Telescopes of the Cherenkov Telescope Array (CTA), with emphasis on cost and performance optimization and on reliability. The fully digital design of the trigger and readout system makes it possible to operate the camera at high event rates and to precisely adjust and understand the trigger system. The novel design of the front-end electronics achieves a dynamic range of over 3,000 photoelectrons with only one electronics readout circuit per pixel. Here we report on the performance parameters of the camera obtained during the first year of operation in the field, including operational stability and optimization of calibration algorithms.
分类： 天文学 >> 天文学 提交时间： 2023-02-19
摘要： Inverse mass cascade is a key feature of statistically steady state for self-gravitating collisionless dark matter flow (SG-CFD). Continuous mass transfer from small to large mass scales (inverse) is formulated. Direct effect of mass cascade on halo mass function is presented. Mass cascade is local, two-way, and asymmetric in mass space. Halos inherit/pass their mass from/to halos of similar size. Two regimes are identified: a propagation range with scale-independent rate of mass transfer and a deposition range with cascaded mass consumed to grow halos. Dimensional analysis leads to a power-law mass function in propagation range with a geometry exponent ${\lambda}$. A fundamental merging frequency $f_0{\sim}m_p^{\lambda-1}a^{-1}$ is identified, where $a$ is scale factor. Particle mass $m_p$ can be determined if that frequency is known. Rate of mass transfer ${\epsilon}_m{\sim}a^{-1}$ is independent of halo mass, a key feature of propagation range. Typical halos grow as $m_h{\sim}a^{3/2}$ and halo lifespan scales as ${\sim}m_h^{-\lambda}$. Chain reaction of mass cascade provides non-equilibrium dark matter flow a mechanism to continuously release energy and maximize entropy. Continuous injection of mass ("free radicals") at the smallest scale is required to sustain the everlasting inverse mass cascade such that total halo mass $M_h$ increases as $a^{1/2}$. These "radicals" might be directly generated at the smallest Planck scale or by a direct cascade from large to small scales. Entire mass cascade can be formulated by random walk in mass space, where halos migrate with an exponential distribution of waiting time. This results in a heterogeneous diffusion model, where Press-Schechter mass function can be fully derived without relying on any specific collapse models. A double-$\lambda$ mass function is proposed with different $\lambda$ for two ranges and agrees with N-body simulations.
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