分类： 心理学 >> 发展心理学 提交时间： 2020-02-28
摘要： 当依恋对象不在身边时，个体可以通过内部表征的方式通达依恋对象的可得与反应性，获得依恋安全感。然而，现有研究对内部表征通达途径的考察忽略了情节模拟的作用。该研究采用实验组控制组前后测设计，考察是否依恋相关的情节模拟可以通达依恋对象的可得与反应性，帮助个体获得依恋安全感。研究招募正处于恋爱关系中且恋爱时长超过6个月的大学生46名。前测评定依恋相关的困境情境；三天后实验组被试进行依恋相关的情节模拟任务，控制组被试进行情境结果的撰写任务，并再次对情境进行评定。结果发现，相比于控制组，情节模拟组预期伴侣的反应性和依恋安全感有更大提升。以上的研究结果表明，依恋相关的情节模拟可以通达伴侣可得与反应性并帮助个体获得依恋安全感。
分类： 医学、药学 >> 临床医学 提交时间： 2020-02-28
Luo, Sihui
Liu, Wei
Liu, Zhenjun
Zheng, Xueying
Ling, Ping
Ding, Yu
Hong, Changxing
Liu, Zhirong
Liu, Jian
Weng, Jianping
摘要： Here we reported a case of asymptomatic carrier of SARS-CoV-2 infection. A 50-year old woman, lived with her husband in Anqing(Anhui, China) with no significant past medical history, travel history to Wuhan or adjacent area, or exposure to wild animals. She took throat swab test for SARS-CoV-2 nucleic acid due to her husband’s close contact with patients who had SARS-CoV-2 infection. Her results were confirmed positive on February 6, 2020. But she did not report elevation of temperature measurement, nor respiratory or gastrointestinal symptoms and her chest CT scan showed no significant abnormalities. She was hospitalized on February 6 and treated with antiviral agents. During her hospitalization, apart from a mild elevation of liver enzymes after 10-day treatment of lopinavir/ritonavir, she was asymptomatic, with her blood cell count, live and renal function largely normal. Her subcutaneous oxygen saturation stayed above 97%. Chest CT scan was repeated on February 11 and 20, and both were negative for signs of viral pneumonia. Notably, a second set of throat swabs and anal swabs were sent to test for SARS-CoV-2 on February 19, and the results were still confirmed positive. This is a confirmed case of asymptomatic carrier of SARS-CoV-2 infection. Her persistent positive findings in both throat and anal swabs suggested the possibility of healthy carrier of the virus, which adds to the difficulty in preventing transmission of the disease.
分类： 医学、药学 >> 临床医学 提交时间： 2020-02-28
Zikuan Leng
Rongjia Zhu
Wei Hou
Yingmei Feng
Yanlei Yang
Qin Han
Guangliang Shan
Fanyan Meng
Dongshu Du
Shihua Wang
Junfen Fan
Wenjing Wang
Luchan Deng
Hongbo Shi
Hongjun Li
Zhongjie Hu
Fengchun Zhang
Jinming Gao
Hongjian Liu
Xiaoxia Li
摘要： A coronavirus (HCoV-19) has caused the novel coronavirus disease (COVID-19) outbreak in Wuhan, China, Preventing and reversing the cytokine storm may be the key to save the patients with severe COVID-19 pneumonia. Mesenchymal stem cells (MSCs) have been shown to possess a comprehensive powerful immunomodulatory function. This study aims to investigate whether MSC transplantation improve the outcome of 7 enrolled patients with COVID-19 pneumonia in Beijing YouAn Hospital, China from Jan 23, 2020. to Feb 16, 2020. The clinical outcomes, as well as changes of inflammatory and immune function levels and adverse effects of 7 enrolled patients were assessed for 14 days after MSC injection. MSCs could cure or significantly improve the functional outcomes of seven patients with COVID-19 pneumonia in 14 days without observed adverse effect. The pulmonary function and symptoms of all patients with COVID-19 pneumonia were significantly improved in 2 days after MSC transplantation. Among them, two common and one severe patient were recovered and discharged in 10 days after treatment. After treatment, the peripheral lymphocytes were increased and the overactivated cytokine-secreting immune cells CXCR3 CD4 T cells, CXCR3 CD8 T cells, and CXCR3 NK cells were disappeared in 3-6 days. And a group of CD14 CD11c CD11bmid regulatory DC cell population dramatically increased. Meanwhile, the level TNF-α is significantly decreased while IL-10 increased in MSC treatment group compared to the placebo control group. Furthermore, the gene expression profile showed MSCs were ACE2- and TMPRSS2- which indicated MSCs are free from COVID-19 infection. Thus, the intravenous transplantation of MSCs was safe and effective for treatment in patients with COVID-19 pneumonia, especially for the patients in critically severe condition.
分类： 医学、药学 >> 预防医学与公共卫生学 分类： 统计学 >> 生物与医学统计学 提交时间： 2020-02-28
摘要： 目的 建立一种数据驱动的实用方法预测突发全新传染性疾病的疫情趋势，通过动态预判疫情风险与分级为防控策略提供量化依据。方法 在移动平均法的基础上予以改进，提出一种移动平均预测限（Moving Average Prediction Limits, MAPL）方法，采用既往重症急性呼吸综合征（Severe Acute Respiratory Syndrome，SARS）疫情数据验证MAPL方法对疫情趋势和风险预判的实用性。追踪本次新型冠状病毒（COVID-19）感染疫情从2020年1月16日起的官方公布数据，采用MAPL方法预判疫情变动趋势与疫区适时风险分级。 结果 基于MAPL方法分析显示，2020年2月初全国COVID-19感染疫情达到峰值。经过前期积极防控，2月中旬起全国疫情整体呈下降趋势。到2月下旬各地疫情有明显的区域性差异。与湖北地区相比，非湖北地区新增病例数下降速度快且未来疫情加重的风险相对较小。在几个重要的疫情输入省份，新增确诊病例数和可疑病例数的发展趋势一致，但消减速度在各省份间存在差异。 结论 MAPL方法可以辅助判断疫情趋势并适时预判风险分级，各疫情输入区可结合当地实际与疫情风险分级规划落实差异化精准防控策略。
分类： 生物学 >> 生物化学 提交时间： 2020-02-28
摘要： 肺癌作为一种严重威胁人类生命健康的疾病，尽管治疗方法种类较多，但如何把握治疗时机，为患者确定最有效的治疗用药仍然是一个难题。尿液蛋白质组可以敏感的反映机体的生理变化，有希望反映药物治疗后机体的病理或生理变化。为了研究晚期肺癌患者使用不同的药物进行治疗时其尿液蛋白质组的变化情况，通过收集晚期肺癌患者治疗前后的不同时间的尿液样本，使用液相色谱联用质谱（LC-MS / MS）来检测其尿蛋白组的变化。比较结果发现，当不同的患者使用不同药物治疗后，差异蛋白的变化各不相同，其差异蛋白反映的生物学过程变化和患者的临床表现变化较为一致。这项研究结果表明，（1）能够通过尿蛋白的变化反映不同药物治疗后患者的病理生理变化；（2）当不同患者使用相同药物治疗后，尿蛋白的变化能够反映出患者体内不同的病理生理变化，且和患者的临床病情评估结果较为一致。这些发现有可能为辅助临床治疗提供重要信息。
分类： 医学、药学 >> 基础医学 提交时间： 2020-02-27
摘要： Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified lineage B coronavirus, causing rapid worldwide outbreak of Corona Virus Disease 2019 (COVID-19). Despite genetically closed to SARS-CoV, SARS-CoV-2 seems to possess enhanced infectivity and subtle different clinical features, which may hamper the early screening of suspected patients as well as the control of virus transmission. Unfortunately, there are few tools to predict the potential target organ damage and possible clinical manifestations caused by such novel coronavirus. To solve this problem, we investigate the potential host cell entry mechanisms of SARS-CoV-2 through bioinformatics. Using the online single-cell sequence datasets, we analyze the expression of major receptor in host cells that mediates the virus entry, including angiotensin converting enzyme 2 (ACE2), and its co-expressed membrane endopeptidases. The results indicated the differential expression of ADAM10 and ADAM17 might contribute to the ACE2 shedding and affect the membrane ACE2 abundance. We further confirm a putative furin-cleavage site reported recently in the spike protein of SARS-CoV-2, which may facilitate the virus-cell fusion. Based on these findings, we develop a novel approach that comprehensively analyzed the virus receptor expression, ACE2 shedding, membrane fusion activity, virus uptake and virus replication to evaluate the infectivity of SARS-CoV-2 to different human organs. Our results indicate that, in addition to airway epithelia, cardiac tissue and enteric canals are susceptible to SARS-CoV-2 as well.
分类： 心理学 >> 心理学其他学科 提交时间： 2020-02-27
摘要： 瞳孔大小是眼动研究中一个重要的参数指标，在一定程度上能够反映人的心理活动并影响他人的心理与行为。一方面，瞳孔变化受到自上而下的知觉与注意、情绪与动机、心理努力、社会认知与发展等因素的影响，另一方面，大瞳孔能引起他人更多的积极评价和积极行为。瞳孔的神经机制（蓝斑-去甲肾上腺素系统）和自适应增益理论解释了瞳孔与心理之间存在紧密联系的原因。瞳孔测量(pupillometry)作为一种有效的眼动追踪方法有助于理解瞳孔与心理的关系,研究者在测量瞳孔时需要关注无关变量（如亮度、注视位置），原始数据处理（如基线校正、眨眼处理）及瞳孔指标选取（如瞳孔直径、震颤频率）等问题，未来研究应继续探讨瞳孔与其他心理之间的关系，并探索更有效地处理和使用瞳孔指标的方法。
分类： 医学、药学 >> 临床医学 提交时间： 2020-02-27
Bing Liang
Junhui Chen
Tao Li
Haiying Wu
Wenjie Yang
Yanjiao Li
Jianchun Li
Congtao Yu
Fangang Nie
Zhaoxia Ma
Mingxi Yang
Panrong Nie
Yanfeng Gao
Chuanyun Qian
Min Hu
摘要： BackgroundThe COVID-19 cases increased very fast in the last two months. The mortality among critically ill patients, especially the elder ones, was relatively high. Considering that most of the dead patients were caused by severe inflammation response, it is very urgent to develop effective therapeutic agents and strategies for these patients. The human umbilical cord mesenchymal stem cells (hUCMSCs) have shown very good capability to modulate immune response and repair the injured tissue with good safety. Case PresentationHere, we reported the treatment process and clinical outcome of a 65-year-old female critically ill COVID-19 patient infected with 2019-nCoV (now called SARS-CoV-2). The significant clinical outcome and well tolerance was observed by the adoptive transfer of allogenic hUCMSCs.ConclusionsOur results suggested that the adoptive transfer therapy of hUCMSCs might be an ideal choice to be used or combined with other immune modulating agents to treat the critically ill COVID-19 patients.
分类： 医学、药学 >> 药学 分类： 医学、药学 >> 预防医学与公共卫生学 提交时间： 2020-02-27
摘要： 2019年12月，自武汉开始我国爆发严重的新型冠状病毒（2019-nCoV）感染疫情，急需开发2019-nCoV治疗药物。冠状病毒非结构蛋白 (Nonstructural protein, NSP) 在病毒基因组复制以及转录过程中起重要作用，在冠状病毒家族中普遍保守，是冠状病毒重要功能蛋白。其中，NSP14蛋白兼具核酸外切酶和甲基转移酶功能，是抗SARS和其他冠状病毒药物研究的重要靶点。序列分析表明, SARS coronavirus (PDB ID: 5nfy) 与武汉华南海鲜批发市场新型冠状病毒分离毒株 (GenBank: MN985325.1)氨基酸序列同源性为98.7%。本研究通过已发表的SARS-NSP14晶体结构 (PDB ID: 5nfy) 进行同源建模，构建2019-nCoV-NSP14的蛋白三维结构模型，对其N端-甲基转移酶以及C端-甲基转移酶结构功能域分别进行虚拟筛选，筛选出了18个对NSP14有抑制活性的化合物。其中沙奎那韦 (Saquinavir)、溴隐亭 (Bromocriptine)、黄芩苷 (Baicalein) 以及金丝桃素 (Hypericin) 能同时作用于NSP14蛋白上述两个重要功能域。该结果提示已知抗HIV药物-Saquinavir以及中药抗病毒重要活性成分-黄芩苷以及金丝桃素，可能以2019-nCoV-NSP14蛋白为靶标，发挥抗病毒效应，可作为抗2019-nCov候选药物进行下一步研究。
分类： 心理学 >> 认知心理学 提交时间： 2020-02-26
摘要： 借鉴行为经济学家开创的应用行为决策于贫困研究的新范式, 选取我国“连片特困地区”的贫困者为研究对象。首先建构“认知和动机双视角的行为贫困陷阱”的立论模型; 然后通过“贫困所致认知后果影响后继决策行为的心理机制和神经机制”, 以及“贫困所致认知和动机后果共同影响后继决策行为的作用机制”来探索贫困所致心理后果与后继决策行为间的因果效应; 最后进行“贫困所致认知功能改变影响后继决策行为的随机控制实验”和“贫困所致自我认同改变影响后继决策行为的现场干预研究”, 旨在通过“扶志和扶智”达到“授人以渔”, 并从中提炼出可供扶贫政策参考的管理对策。
分类： 医学、药学 >> 临床医学 提交时间： 2020-02-26
Jinnong,Zhang
Wenjing,Wang
Bo,Peng
Wei,Peng
Yisheng,Zhang
Yaling,Wang
Yan,Wan
Jiang,Chang
Ling,Mao
Xiaoping，Miao
Yifan,Zhou
Yanan,Li
Yu,Hu
Bo,Hu
摘要： Background: The efficient transmission of Severe Acute Respiratory Syndrome-2 Coronavirus (SARS-CoV-2) from patients to healthcare workers or family members has been a worrisome and prominent feature of the ongoing outbreak. On the basis of clinical practice and in-vitro studies, we postulated that post-exposure prophylaxis (PEP) using Arbidol is associated with decreased infection among individuals exposed to confirmed cases of COVID-19 infection. Methods: We conducted a retrospective case-control study on family members and health care workers who were exposed to patients confirmed to have SARS-CoV-2 infection by real-time RT-PCR and Chest CT from January 1 to January 16, 2020. We collected demographic information, work location of exposure, post-exposure prophylaxis information, and symptoms, if any, 24 days after exposure. The relation between post-exposure prophylaxis and infection in household contacts and healthcare workers were respectively analyzed. Results: 27 families and 124 health care workers had evidence of close exposure to patients with confirmed COVID-19. There were no differences in age, profession and sex distribution in the two groups with different post-exposure prophylaxis, table 1. Logistic regression based on the data of the family members and health care workers with Arbidol or Oseltamivir prophylaxis showed that Arbidol PEP was a strong protective factor against the development of COVID-19 (Odds ratio 0·011 , 95% CI 0·001-0·125, P=0·0003 for family members and Odds ratio 0·049, 95%CI 0·003-0·717), P= 0·0276 for health care workers). On the contrary, Oseltamivir was associated with an increase in COVID-19 infection (Odds ratio 20·446, 95% CI 1·407-297·143, P= 0·0271). Conclusions: Our findings suggest Arbidol could reduce the infection risk of the novel coronavirus in hospital and family settings. This treatment should be promoted for PEP use and should be the subject of further investigation.
分类： 心理学 >> 管理心理学 分类： 心理学 >> 社会心理学 提交时间： 2020-02-25
摘要： 全球化带来了丰富的多元文化经验，开阔了人们视野的同时，也造成了认知负担，进而可能引发对外文化群体的抵触情绪和排斥行为。多元文化经验的普遍性和两面性突显了对其进行合理管理和灵活应用的重要性。然而，现有的文化能力的理论大多在全球化研究早期提出，已经无法应对全球化带来的新变化。在文化会聚主义理论框架下，将文化视为动态发展的系统，建构以元知识为核心的多元文化能力模型将有助于深入理解全球化问题。新模型的效用检验计划从文化知识管理和群际接触应对两方面检验多元文化能力在跨文化合作情境中的效用与机制，以期为全球化环境中个人与组织开展跨文化交流与合作的实践提供理论指导。
分类： 数学 >> 建模与仿真 分类： 生物学 >> 生物数学 提交时间： 2020-02-25
摘要： 基于经典动力学模型和模型参数自动优化算法, 本文分析了全国当前累计确诊感染病例数大于100（截止到2020年2月16日）的24个省市自治区, 以及湖北省除神农架以外的16个地市从2020年1月20日至2月16日的累计确诊病例数, 并对相应省市地区疫情可能的结束时间和总感染人数的进行了长期预测. 我们的研究表明, 在目前严防严控措施下, 全国大部分省市的疫情将于2月底前基本结束, 而湖北省内疫情也有望于3月中旬结束, 但是武汉市的疫情可能要持续到4月初. 通过对比公开数据与预测值, 我们建议加强对黑龙江、河北、江西、安徽、贵州和四川六省, 以及湖北省内武汉、荆州、鄂州、随州、天门和恩施六个地市的的监控, 以防疫情死灰复燃. 此外, 分析结果提示, 在疫情发展前期, 天津、河北、重庆、四川、海南和广西等省, 以及湖北省下辖多个地市可能存在着聚集性感染, 这有待于疫后进一步的流行病学调查确认.
分类： 心理学 >> 管理心理学 提交时间： 2020-02-25
摘要： 本研究基于自我决定理论和耶鲁态度改变理论，以创意提出者的内在动机倾向为起点，探索其对创意质量的影响，创意质量和创意提出者所获奖励进一步影响了创意实施，纵向追踪创意从提出到实施的创新历程。针对251份多时点、多来源配对数据的分析结果表明：（1）创意提出者的内在动机倾向积极预测创意质量；（2）创意质量对创意实施有显著的正向影响；（3）创意提出者所获奖励积极预测创意实施；（4）创意质量和创意提出者所获奖励交互影响创意实施：对于低奖励的创意提出者而言，创意质量对创意实施的正向影响更加强烈。以上研究发现弥合了创造力领域和创意实施领域的理论分野，对企业创新管理实践有较强的启发。
分类： 生物学 >> 病毒学 提交时间： 2020-02-25
Xia, Jia
Lu, Guoliang
Lu, Jing
Zhang, Jiahui
Feng, Lin
Wang, Bing
Yu, Hang
Xu, Yingjie
Lin, Jinzhong
摘要： Frequent outbreaks of coronavirus make the development of an effective vaccine imperative. Recently, vaccines based on in-vitro transcribed messenger RNA (mRNA) have shown great potential. The streamlined manufacturing of mRNA molecules, combined with the superior flexibility in the antigen screening, greatly accelerates the development process. When using an mRNA platform to develop a vaccine, initial antigen choice plays a crucial role in determining the final efficacy and safety of the vaccine. Furthermore, mRNA sequences that encode antigens require extensive optimization to ensure highly efficient and sustained expression. Our ongoing efforts to develop an effective mRNA vaccine against 2019-nCoV place emphasis on the virus-like particles (VLPs) as the presenting antigen. At the same time, our second fast track uses mRNA to express the receptor-binding domain of the spike protein(S-RBD). After extensive optimization, an mRNA cocktail containing three genes is able to produce 2019-nCoV virus-like particles highly similar to the native 2019-nCoV. Meanwhile, an mRNA vaccine candidate expressing S-RBD is being tested in mice for its immunogenicity. We will next compare both the efficacy and the safety of the two mRNA vaccines based on S-RBD and VLPs, respectively.
分类： 医学、药学 >> 军事医学与特种医学 提交时间： 2020-02-25
摘要： 特种医学是运用医学科学的基本原理和技术方法，解决包括航空与航天医学、航海与潜水医学、高原医学、深井医学、职业病学等领域涉及到的特殊医学问题。它是一个由任务驱动的医学领域，具有条件严苛、时间紧、任务强的特点，特殊环境会引起心理、生理等多种问题，由此衍生出新的医学保障需求。芳香疗法是一种有别于传统药物治疗的自然疗法，具有渗透性好、代谢快、不滞留、毒性小等特点，天然芳香分子能够透过血脑屏障直接刺激嗅觉神经快速调节脑功能以达到释放情绪、改善认知、促进人体健康目的。本文提出的现代精准芳香科技能够继承传统芳香疗法的优势，并弥补其不足，能够为科学化、精准化地解决特种医学领域所面临的多种问题提供创新解决方案，在满足特种医学需求的同时，为芳香疗法、芳香中药的应用提供更多的可能性。
分类： 物理学 >> 交叉学科物理及相关领域的科学与技术 分类： 生物学 >> 病毒学 提交时间： 2020-02-25
摘要： 由于春运出湖北省高峰和全国各地管控开始之间的时间差，使得在这个时间段内，除湖北外的国内地区是个输入一代到感染二代之间独立自然连续传播体系。基于此，我们使用正态分布的线性叠加来拟合全国除湖北外每日新增的数据，简单模型预测和实际新增结果的高度吻合验证了除湖北外是个近似理想系统。拟合计算得到的新冠病毒可再生系数R0=2.2，一代到二代的峰值传播时间是7天。我们还讨论了偏离理想传播体系的原因并分析了一些省的特殊情况。
分类： 医学、药学 >> 基础医学 分类： 医学、药学 >> 医学、药学其他学科 提交时间： 2020-02-25
摘要： 自2019年12月爆发以来，2019年新型冠状病毒已在全球造成2596人死亡，并且有超过11，000名患者仍处于严重状况。该病毒和由该病毒引起的医疗状况被命名为SARS-CoV-2和COVID-19。虽然已经广泛应用了抗病毒、对症和功能支持性疗法，每天仍有100多名患者死于该病毒感染。COVID-19最常见的致命并发症是急性呼吸窘迫综合征（ARDS）。SARS-CoV-2在世界范围内的大流行可能仍然存在。其它病毒感染引起的肺炎亦可导致ARDS，出现类似的危重情形，这些病毒包括如非典型的急性呼吸系统综合症（SARS）、中东呼吸综合征（MERS）和流感病毒引起的肺炎。因此，制定更有效的降低病毒所致的ARDS死亡率的策略，不但是当前抗新冠疫情的迫切需要，也是全球范围内降低病毒性肺炎死亡率的长期需要。ARDS曾被称为湿肺，血管泄漏导致的肺水肿是其最重要的病理特征之一，重型COVID-19的临床表现和胸部计算机断层扫描图像特征（白肺）符合ARDS。确定水肿液从何处及如何渗漏到肺部，是制定基于机制的预防和阻止水从肺毛细管向肺间质渗漏的策略，降低湿肺死亡率的关键。对于轻度和中度病例，非类固醇消炎药，如用于风湿性关节炎的药物，可能有助于防止和减少这种漏水。免疫抑制剂（如西罗莫司和巨蜥）可能使病毒感染、免疫反应和非免疫炎症造成的损伤高峰时间错开，从而降低肺漏水程度，防止危及生命情况出现。使用清火中草药可能也有抗炎用。对于严重病例，血液透析可能是消除大多数炎症介质和细胞毒性物质的有效策略。
分类： 计算机科学 >> 计算机应用技术 提交时间： 2020-02-24
zhidong,Xue
Lei,Zhao
Tailang,Yin
Yan,Fu
Zehua,Lyu
yiping,Dang
Yujiang,Zeng
Silou,Huang
Bing,Qu
Hongya,Lyu
Chen,Huang
Zhiyou,Kong
Kepei,Xu
Feipeng,Zhou
Hexun,Dong
He,Hu
Jing,Tang
Senyuan,Xue
Zhixiang,Fang
Jinxiang,Lu
摘要： Background：The COVID-19 Epidemic emerged in Wuhan, Hubei province, China. Ever since Wuhan lockdown on January 23rd, mass quarantines were exercised on Wuhan and other epidemic areas of China. We aimed to clarify how ordinary Wuhan people defend against COVID-19 epidemic at home through the Internet survey. Methods：A questionnaire survey, consisting of 30 questions were posted on the Internet. The following aspects were investigated: household preventive measures, self-monitoring of discomfort symptoms, immunity boosting against the epidemic, frequency and reasons of outgoing and mental status of the isolated people. The questionnaire was circulated on Wechat. We marked the areas based on the surveyed network IP addresses and categorized respondents into group A(Wuhan), B(Hubei Province excluding Wuhan ), C, and D based on the epidemic severity of their areas announced by Baidu.com at 17:00 on February 8, 2020. And a comparative study was conducted to illustrate how Wuhan people took the anti-COVID-19 strategies and how efficient these preventive measures were. Findings：In terms of discomfort symptoms, Wuhan, as Group A, had the lowest asymptomatic percentages (70.2%), compared to the average 78.5% (±7%). Considering the three typical symptoms for the COVID-19, i.e., cough, fever and fatigue, Wuhan (9.67%) greatly deviated from the average (7.68%). The fatigue was the most significant factor in the deviation, exceeding the average by 1.35%. In terms of household protection measures, most people or families were able to take effective protection measures with very low frequency of going out, but the percentage of those who took this practice was obviously smaller in Wuhan and Hubei Province. From the aspect of going out, most of the people in Wuhan only went out for shopping and work, with a small number of people for social gathering. In terms of immunity boosting, compared with Group C and D, it was relatively lower in Wuhan. Overall, most people chose to enhance their immunity through regular schedule, exercise, sufficient nutrition. Only 33.44% of people in Group A did not go out, and 59.97% had to go out for living supplies, which was the highest level among the four groups. However, the percentage of people who went out for work and unnecessary activities remains the lowest while 1% of the population went out for public welfare activities, higher than other groups. Worry about the family health topped all the parameters for all the groups. Among them, Wuhan has reached a maximum of 49.61%, higher than the average level of 36.62% (± 10.69%). Mental status except for feeling bored and lonely were the highest in Wuhan. Suggestions：When the epidemic prevention and control is still in a sticky state, and Wuhan started a stricter control measure, the closed management of communities, on Feb 11, 2020, it is expected that our findings can provide some insights into the current household preventive actions and arouse more attentions of the public to some ignored preventive precautions. Unnecessary outgoing should be strictly abandoned. Regular schedule, exercises and nutrition were the top 3 measures participants would choose to enhance their own immunity system. It seems that people in Wuhan would choose nutrition and regular scheduler rather than exercises as the primary immunity-boosting ways. Exercise should be especially advocated as an effective way to enhance the immunity system. In terms of physical condition, people in Wuhan should take more active measures when symptoms occurred. The mentality is also an important aspect requiring intensive attention with the conduct of stricter control management in Wuhan while the rest groups gradually resume to work and ordinary life.
分类： 生物学 >> 生态学 提交时间： 2020-02-24
Xiong Li
Supriyo Basak
Rui Zhou
Wei-zhe Zhang
Yao Fu
Xin-mao Zhou
Chao Shi
Hou-Cheng Xi
Yong-ping Yang
摘要： 地区文化（如宗教、饮食或旅游文化）有时会驱动入侵生物的扩散，我们必须采取措施来阻止入侵生物融入大众文化。
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