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1. chinaXiv:202003.00053 [pdf]

胡蜂毒对类风湿关节炎实验模型具有潜在的治疗作用

Yuan, Gao; Zhi-Bin, Yang; Wan-Xin, Yu; Xiao-Mei, Duan; Lian-Li, Ni; Heng, Liu; Hai-Rong, Zhao; Huai, Xiao; Cheng-Gui, Zhang; Yu, Zhao
Subjects: Medicine, Pharmacy >> Traditional Chinese Medicine and Chinese Materia Medica

类风湿关节炎(RA)是一种自身免疫性疾病。胡蜂毒被认为是云南景颇族的一种传统民间药物,具有治疗类风湿性关节炎的作用。本研究旨在探讨胡蜂毒对实验性大鼠类风湿性关节炎的改善作用。我们建立了II型胶原(CII)诱导的SD大鼠关节炎(CIA)模型,并检测了炎症抑制作用和自身免疫反应。通过对患肢的肿胀、组织病理学评分及组织病理学改变来评价胡蜂毒(WV)的抗关节炎作用。检测了IL-6、TNF-α和IL-1β的表达水平以及外周血中炎症细胞的数量来。采用流式细胞术检测大鼠脾脏T细胞亚群比例的变化,同时测定脏器指数和免疫血清球蛋白水平。结果表明,不同剂量的WV(0.125、0.25、0.5 mg/kg)对CIA大鼠足肿胀和关节炎评分有显著的缓解作用(P < 0.05)。WV(0.25、0.5 mg/kg)能减轻大鼠踝关节滑膜组织病变,滑膜细胞增生、炎性细胞浸润的组织病理学评分(P < 0.05)。在免疫调节方面,0.5 mg/kg WV可降低免疫血清球蛋白水平(P < 0.05),我们进一步发现,0.5 mg/kg的WV可抑制Th细胞的免疫应答,同时显著增强脾脏细胞中Tc细胞和Treg细胞的功能(P < 0.05)。WV的免疫抑制作用类似于其对大鼠血清中IL-1β、TNF-α、IL-8、IL-6、cox-2和PGE2水平的抑制。综上所述,这些发现表明WV具有抗关节炎的活性,这可能与它们对免疫的调节和抗炎作用有关。

submitted time 2020-03-13 Hits3390Downloads96 Comment 0

2. chinaXiv:201802.00685 [pdf]

An Explanation of the Interactions between Waves and Electrons: Discussion of Electromagnetic Fields

Weiye Xu
Subjects: Physics >> The Physics of Elementary Particles and Fields

The interactions between waves and electrons are the basis of vacuum tubes and particle accelerators. In order to further understand the interactions, we proposed a new electromagnetic model. In this model, the photon is composed of two elementary particles – ephoton and mphoton, which are the basic particles that form the electric fields and magnetic fields, respectively. There are many ephotons around the electrons and the electrons can absorb the ephotons. The proposed electromagnetic model can well explain the electromagetic phenomena and the interactions between waves and electrons.

submitted time 2020-03-13 Hits9190Downloads1376 Comment 0

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