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1. chinaXiv:202002.00017 [pdf]

自我肯定缓冲新冠疫情引发的焦虑反应:一项随机对照研究

李世峰; 吴艺玲; 张福民; 许琼英; 周爱保
Subjects: Psychology >> Social Psychology

当个体知觉到环境中存在威胁时,就会自动的引发个体的应激反应。而长期的应激会使个体产生一系列严重的心理和身体健康问题。大量的研究发现肯定自我价值可以缓冲由应激引发的负面情绪和身体反应。本研究通过实验的方法考察了肯定自我价值是否可以降低新冠肺炎(COVID-19)疫情引发的焦虑和抑郁情绪反应。220名被试被随机分配到自我价值肯定任务组或控制任务组,被试在干预前(2月2日)和一个星期后(2月9日)完成焦虑和抑郁测量。研究结果发现相对于控制组在一周后比前测时表现出更严重的焦虑情绪,自我价值肯定组在前测和一周后在焦虑情绪上没有显著的变化,这一效应在控制了性别、年龄、受教育水平和家庭年收入后仍然存在。这些结果表明简短的(约10分钟)对自我价值的反思可以帮助个体缓冲疫情引发的焦虑情绪反应。这一发现对于从社会心理的视角进行疫情防护提供了重要的科学证据。

submitted time 2020-03-27 Hits2726Downloads91 Comment 0

2. chinaXiv:201802.00685 [pdf]

An Explanation of the Interactions between Waves and Electrons: Discussion of Electromagnetic Fields

Weiye Xu
Subjects: Physics >> The Physics of Elementary Particles and Fields

The interactions between waves and electrons are the basis of vacuum tubes and particle accelerators. In order to further understand the interactions, we proposed a new electromagnetic model. In this model, the photon is composed of two elementary particles – ephoton and mphoton, which are the basic particles that form the electric fields and magnetic fields, respectively. There are many ephotons around the electrons and the electrons can absorb the ephotons. The proposed electromagnetic model can well explain the electromagetic phenomena and the interactions between waves and electrons.

submitted time 2020-03-13 Hits9227Downloads1389 Comment 0

3. chinaXiv:202003.00008 [pdf]

Germline Polymorphisms and Length of Survival of Nasopharyngeal Carcinoma: An Exome-Wide Association Study in Multiple Cohorts

Yun-Miao Guo; Jie-Rong Chen; Yan-Chun Feng; Chua, Melvin L. K. ; Zeng, Yanni ; Edwin Pun Hui; Allen K. C. Chan; Lin-Quan Tang; Lin Wang; Qian Cui; Hui-Qiong Han; Chun-Ling Luo; Guo-Wang Lin; Yan Liang; Yang Liu; Zhong-Lian He; Yu-Xiang Liu; Pan-Pan Wei; Chu-Jun Liu; Wan Peng
Subjects: Medicine, Pharmacy >> Clinical Medicine

Germline polymorphisms have been linked with differential survival outcomes in cancers but have not been well studied in nasopharyngeal carcinoma (NPC). Here, two-phase association study is conducted to discover germline polymorphisms that are associated with the prognosis of NPC. The discovery phase includes two consecutive hospital cohorts of patients with NPC from Southern China. Exome-wide genotypes at 246,173 single nucleotide polymorphisms (SNPs) are determined, followed by survival analysis for each SNP under Cox proportional hazards regression model. Candidate SNP is replicated in another two independent cohorts from Southern China and Singapore. Meta-analysis of all samples (n = 5,553) confirm that the presence of rs1131636-T, located in the 3′-UTR of RPA1, confers an inferior overall survival (HR = 1.33, 95% CI = 1.20-1.47, P = 6.31 × 10-8). Bioinformatics and biological assays show that rs1131636 has regulatory effects on upstream RPA1. Functional studies further demonstrate that RPA1 promoted the growth, invasion, migration, and radioresistance of NPC cells. Additionally, miR-1253 has been identified as a suppressor for RPA1 expression, likely through regulation of its binding affinity to rs1131636 locus. Collectively, these findings provide a promising biomarker aiding in stratifying patients with poor survival, as well as a potential drug target for NPC.

submitted time 2020-03-06 Hits7737Downloads222 Comment 0

4. chinaXiv:202003.00006 [pdf]

行为贫困陷阱的心理机制与管理对策:基于认知与动机双视角

徐富明; 黄龙; 张慧; 相鹏; 刘腾飞; 李亚红
Subjects: Psychology >> Cognitive Psychology

借鉴行为经济学家开创的应用行为决策于贫困研究的新范式, 选取我国“连片特困地区”的贫困者为研究对象。首先建构“认知和动机双视角的行为贫困陷阱”的立论模型; 然后通过“贫困所致认知后果影响后继决策行为的心理机制和神经机制”, 以及“贫困所致认知和动机后果共同影响后继决策行为的作用机制”来探索贫困所致心理后果与后继决策行为间的因果效应; 最后进行“贫困所致认知功能改变影响后继决策行为的随机控制实验”和“贫困所致自我认同改变影响后继决策行为的现场干预研究”, 旨在通过“扶志和扶智”达到“授人以渔”, 并从中提炼出可供扶贫政策参考的管理对策。

submitted time 2020-03-04 Hits6414Downloads214 Comment 0

5. chinaXiv:201909.00183 [pdf]

眼动技术在个体认知能力差异研究中的应用

陆润豪; 张兴利; 施建农
Subjects: Psychology >> Cognitive Psychology

本文从可能性和可行性两方面介绍和论述了眼动技术在个体认知能力差异研究中的应用。在可能性方面,个体眼动特征具有的良好的重测信度和内部一致性信度;在可行性方面,已有研究利用注视和眼跳相关指标、眼动轨迹和瞳孔直径这三类指标对该问题进行探索,结果均发现这些眼动特征与认知能力之间存在着密切关系。今后研究应继续深入探索两者关系的内在认知和神经机制,并尝试结合人工智能算法开发高信效度的眼动认知测验。

submitted time 2020-03-03 Hits11495Downloads406 Comment 0

6. chinaXiv:202002.00074 [pdf]

Molecular karyotypes of loquat (Eriobotrya japonica) aneuploids can be detected by using SSR markers combined with quantitative PCR irrespective of heterozygosity

Wen, Guo; Dang, Jiangbo; Xie, Zhongyi; Wang, Jinying; Jiang, Pengfei; Guo, Qigao; Liang, Guolu
Comment:This article has been published online in Plant Methods (https://plantmethods.biomedcentral.com/articles/10.1186/s13007-020-00568-7)
Subjects: Biology >> Botany
Subjects: Agriculture, Forestry,Livestock & Aquatic Products Science >> Horticulture

Background: Aneuploidy, a condition caused by an imbalance between the relative dosages of chromosomes, generally produces a novel phenotype specific to the molecular karyotype. Few techniques are currently available for detecting the molecular karyotypes of aneuploids in plants. Methods: By PCR amplification of 209 pairs of SSR primers, 17 pairs of SSR primers with no polymorphism and stable amplification in 23 different ploidy loquat were screened out. Seventeen SSR markers combined with qPCR for detection of aneuploid loquat H39 (2n=2x+5=39) karyotype variation. To verify the method for detection of aneuploid karyotype variation, 9 hybrid offspring of Q24 × ‘Huabai No. 1’ and 16 open-pollination progeny of the triploid loquat A313 and A322 were obtained, and we detected their chromosome numbers using conventional cytological methods. The SSR-qPCR method was used to detect the molecular karyotypes of aneuploids in the 9 hybrid offspring of Q24 × ‘Huabai No. 1’ and 16 open-pollination progeny of the triploid loquat A313 and A322. Results: Based on this imbalance in chromosome dosage, a new approach (referred to as ‘SSR-qPCR’) combining simple sequence repeat (SSR) markers and quantitative real-time PCR (qPCR) has been developed and utilized to detect some common aneuploids irrespective of heterozygosity. We screened 17 specific SSR markers covering all loquat linkage groups and redesigned 6 pairs of primers for SSR markers that can detect loquat chromosome aneuploidies. The SSR-qPCR detection results obtained for hybrid progeny and open-pollination progeny of triploid loquat showed diagnostic accuracies of 88.9% and 62.5%, respectively, compared with the chromosome preparation results. Limitations: Loquat genome sequences have not been published, available SSR markers are currently limited. Conclusion: SSR-qPCR can detect loquat aneuploids and be used to construct the entire molecular karyotypes of aneuploid individuals. Therefore, this method offers a novel alternative for the detection of chromosome aneuploidies.

submitted time 2020-03-03 Hits6824Downloads218 Comment 0

7. chinaXiv:202002.00087 [pdf]

多维对数正态作答时间模型:对潜在加工速度多维性的探究

詹沛达
Subjects: Psychology >> Psychological Measurement

在心理与教育测量中,潜在加工速度反映学生运用潜在能力解决问题的效率。为在多维测验中探究潜在加工速度的多维性并实现对其进行参数估计,本研究以2012年PISA计算机化数学测验中题目作答时间数据为例,提出多维对数正态作答时间模型。实证数据分析及模拟研究结果表明:(1)在多维测验中潜在加工速度具有与潜在能力相匹配的多维结构;(2)新模型能够精确估计个体水平的多维潜在加工速度及与作答时间有关的题目参数。

submitted time 2020-03-02 Hits8624Downloads197 Comment 0

8. chinaXiv:201911.00003 [pdf]

纵向学习诊断模型的马尔可夫参数估计策略——让诊断反馈更及时

詹沛达
Subjects: Psychology >> Psychological Measurement

及时性诊断反馈有助于学生和教师根据当前诊断结果及时调整后续学习和教学规划。针对当前纵向学习诊断模型采用的同时性估计策略无法提供及时性诊断反馈的问题,本研究提出一种新的马尔可夫估计策略,并通过模拟研究对比探究了同时性、马尔可夫、简单分离和锚题分离四种参数估计策略的表现。结果显示四者的表现具有较高一致性且呈现如下相对优劣顺序:同时性>马尔可夫>锚题分离≥简单分离。表明新策略在略微牺牲参数估计精度的前提下,可为实践者提供及时性诊断反馈,更符合“为学习而测评”的理念和形成性评价的需求。

submitted time 2020-02-29 Hits9838Downloads491 Comment 0

9. chinaXiv:202002.00071 [pdf]

Potential treatment of Chinese and Western Medicine targeting nsp14 of 2019 nCov

Liu Chao ; Zhu Xiaoxiao ; Lu Yiyao ; Jia Xu ; Yang Tai
Subjects: Medicine, Pharmacy >> Pharmacology

2019年12月,自武汉开始我国爆发严重的新型冠状病毒(2019-nCoV)感染疫情,急需开发2019-nCoV治疗药物。冠状病毒非结构蛋白 (Nonstructural protein, NSP) 在病毒基因组复制以及转录过程中起重要作用,在冠状病毒家族中普遍保守,是冠状病毒重要功能蛋白。其中,NSP14蛋白兼具核酸外切酶和甲基转移酶功能,是抗SARS和其他冠状病毒药物研究的重要靶点。序列分析表明, SARS coronavirus (PDB ID: 5nfy) 与武汉华南海鲜批发市场新型冠状病毒分离毒株 (GenBank: MN985325.1)氨基酸序列同源性为98.7%。本研究通过已发表的SARS-NSP14晶体结构 (PDB ID: 5nfy) 进行同源建模,构建2019-nCoV-NSP14的蛋白三维结构模型,对其N端-甲基转移酶以及C端-甲基转移酶结构功能域分别进行虚拟筛选,筛选出了18个对NSP14有抑制活性的化合物。其中沙奎那韦 (Saquinavir)、溴隐亭 (Bromocriptine)、黄芩苷 (Baicalein) 以及金丝桃素 (Hypericin) 能同时作用于NSP14蛋白上述两个重要功能域。该结果提示已知抗HIV药物-Saquinavir以及中药抗病毒重要活性成分-黄芩苷以及金丝桃素,可能以2019-nCoV-NSP14蛋白为靶标,发挥抗病毒效应,可作为抗2019-nCov候选药物进行下一步研究。

submitted time 2020-02-27 Hits8187Downloads507 Comment 0

10. chinaXiv:201904.00073 [pdf]

Prevent culture-driven invasive species spread

Xiong Li; Supriyo Basak; Rui Zhou; Wei-zhe Zhang; Yao Fu; Xin-mao Zhou; Chao Shi; Hou-Cheng Xi; Yong-ping Yang
Subjects: Biology >> Ecology

地区文化(如宗教、饮食或旅游文化)有时会驱动入侵生物的扩散,我们必须采取措施来阻止入侵生物融入大众文化。

submitted time 2020-02-24 Hits9860Downloads491 Comment 0

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