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1. chinaXiv:202002.00063 [pdf]

Perspectives on Active Preventive Measures of Wuhan People against COVID-19 Epidemic at Home: A Comparative Study

zhidong,Xue; Lei,Zhao; Tailang,Yin; Yan,Fu; Zehua,Lyu; yiping,Dang; Yujiang,Zeng; Silou,Huang; Bing,Qu; Hongya,Lyu; Chen,Huang; Zhiyou,Kong; Kepei,Xu; Feipeng,Zhou; Hexun,Dong; He,Hu; Jing,Tang; Senyuan,Xue; Zhixiang,Fang; Jinxiang,Lu
Subjects: Computer Science >> Computer Application Technology

Background:The COVID-19 Epidemic emerged in Wuhan, Hubei province, China. Ever since Wuhan lockdown on January 23rd, mass quarantines were exercised on Wuhan and other epidemic areas of China. We aimed to clarify how ordinary Wuhan people defend against COVID-19 epidemic at home through the Internet survey. Methods:A questionnaire survey, consisting of 30 questions were posted on the Internet. The following aspects were investigated: household preventive measures, self-monitoring of discomfort symptoms, immunity boosting against the epidemic, frequency and reasons of outgoing and mental status of the isolated people. The questionnaire was circulated on Wechat. We marked the areas based on the surveyed network IP addresses and categorized respondents into group A(Wuhan), B(Hubei Province excluding Wuhan ), C, and D based on the epidemic severity of their areas announced by Baidu.com at 17:00 on February 8, 2020. And a comparative study was conducted to illustrate how Wuhan people took the anti-COVID-19 strategies and how efficient these preventive measures were. Findings:In terms of discomfort symptoms, Wuhan, as Group A, had the lowest asymptomatic percentages (70.2%), compared to the average 78.5% (±7%). Considering the three typical symptoms for the COVID-19, i.e., cough, fever and fatigue, Wuhan (9.67%) greatly deviated from the average (7.68%). The fatigue was the most significant factor in the deviation, exceeding the average by 1.35%. In terms of household protection measures, most people or families were able to take effective protection measures with very low frequency of going out, but the percentage of those who took this practice was obviously smaller in Wuhan and Hubei Province. From the aspect of going out, most of the people in Wuhan only went out for shopping and work, with a small number of people for social gathering. In terms of immunity boosting, compared with Group C and D, it was relatively lower in Wuhan. Overall, most people chose to enhance their immunity through regular schedule, exercise, sufficient nutrition. Only 33.44% of people in Group A did not go out, and 59.97% had to go out for living supplies, which was the highest level among the four groups. However, the percentage of people who went out for work and unnecessary activities remains the lowest while 1% of the population went out for public welfare activities, higher than other groups. Worry about the family health topped all the parameters for all the groups. Among them, Wuhan has reached a maximum of 49.61%, higher than the average level of 36.62% (± 10.69%). Mental status except for feeling bored and lonely were the highest in Wuhan. Suggestions:When the epidemic prevention and control is still in a sticky state, and Wuhan started a stricter control measure, the closed management of communities, on Feb 11, 2020, it is expected that our findings can provide some insights into the current household preventive actions and arouse more attentions of the public to some ignored preventive precautions. Unnecessary outgoing should be strictly abandoned. Regular schedule, exercises and nutrition were the top 3 measures participants would choose to enhance their own immunity system. It seems that people in Wuhan would choose nutrition and regular scheduler rather than exercises as the primary immunity-boosting ways. Exercise should be especially advocated as an effective way to enhance the immunity system. In terms of physical condition, people in Wuhan should take more active measures when symptoms occurred. The mentality is also an important aspect requiring intensive attention with the conduct of stricter control management in Wuhan while the rest groups gradually resume to work and ordinary life.

submitted time 2020-02-24 Hits70Downloads16 Comment 0

2. chinaXiv:202002.00062 [pdf]

Furin, a potential therapeutic target for COVID-19

Hua Li; Canrong Wu; Yueying Yang; Yang Liu; Peng Zhang; Yali Wang; Qiqi Wang; Yang Xu; Mingxue Li; Mengzhu Zheng; Lixia Chen
Subjects: Medicine, Pharmacy >> Pharmacology

A novel coronavirus (SARS-CoV-2) infectious disease has broken out in Wuhan, Hubei Province since December 2019, and spread rapidly from Wuhan to other areas, which has been listed as an international concerning public health emergency. We compared the Spike proteins from four sources, SARS-CoV-2, SARS-CoV, MERS-CoV and Bat-CoVRaTG13, and found that the SARS-CoV-2 virus sequence had redundant PRRA sequences. Through a series of analyses, we propose the reason why SARS-CoV-2is more infectious than other coronaviruses. And through structure based virtual ligand screening, we foundpotentialfurin inhibitors, which might be used in the treatment of new coronary pneumonia.

submitted time 2020-02-23 Hits622Downloads174 Comment 0

3. chinaXiv:202002.00039 [pdf]

提取干扰对不同类型内隐记忆的影响

黄发杰; 孟迎芳; 严颖
Subjects: Psychology >> Cognitive Psychology

以往研究关于提取阶段的干扰是否会影响内隐记忆存在着异义,其中一个重要因素可能源于所采用的内隐记忆测验类型的差异。本研究采用学习-测验范式,通过四个实验,分别考察了提取干扰对识别式知觉内隐测验、识别式概念内隐测验、产生式知觉内隐测验和产生式概念内隐测验的影响,以期对提取干扰和内隐记忆之间的关系有着更全面的了解。结果表明:(1)词汇判断任务(识别式知觉)和语义分类任务(识别式概念)的启动效应在提取干扰下消失了,(2)而产生式词汇判断任务(产生式知觉)和产生式语义分类任务(产生式概念)在提取干扰下仍发现了明显的启动效应,但与无干扰条件相比,启动效应量也有着明显的减少。由此可见,不同类型的内隐记忆都会受到提取干扰的影响,相比于产生式启动,识别式启动更容易受到提取干扰的破坏。

submitted time 2020-02-22 Hits202Downloads55 Comment 0

4. chinaXiv:202002.00061 [pdf]

2019新型冠状病毒核衣壳蛋白N能发挥病毒编码的RNAi抑制子功能

Mu, Jingfang; Xu, Jiuyue; Shu, Ting; Wu, Di; Huang, Muhan; Ren, Yujie; Li, Xufang; Geng, Qing; Xu, Yi; Qiu, Yang; Zhou, Xi
Subjects: Biology >> Virology

新型冠状病毒肺炎目前仍在武汉和中国其他地区持续。在目前的形势下,进一步了解新型冠状病毒(SARS-CoV-2)的病毒学和病毒与宿主的相互作用,对控制感染、开发有效的治疗方法具有重要意义。RNA干扰(RNA interference,RNAi)是一种进化上保守的真核生物抗病毒免疫机制,目前已发现许多病毒编码自身的RNA干扰抑制因子作为对抗措施。在这项研究中,我们发现SARS-CoV-2编码的核衣壳蛋白(N)有效地抑制了shRNAs或siRNAs触发的RNAi。此外,与许多由其他病毒编码的VSR类似,SARS-CoV-2的VSR在体外与人类细胞中与dsRNA相互作用,显示出双链RNA(dsRNA)结合活性。综上所述,我们的研究结果表明,SARS-CoV-2的N蛋白在人类细胞中表现出VSR活性,这可能是新型冠状病毒的一个关键免疫逃避因子。

submitted time 2020-02-22 Hits299Downloads91 Comment 0

5. chinaXiv:202002.00038 [pdf]

中文阅读中副中央凹预加工的范围与程度研究

张慢慢; 臧传丽; 白学军
Subjects: Psychology >> Cognitive Psychology

在阅读中,读者既能加工当前注视的中央凹视觉区的信息,也能从副中央凹视觉区提取信息并利用该信息预先加工下文词汇,称为预加工或预视。它是熟练阅读的一个关键环节。对副中央凹信息的预加工涉及预视的空间范围和预视程度(即预视量和预视类型)。在拼音文字阅读的研究中,对预视范围与预视程度如何受中央凹加工负荷和副中央凹预加工负荷的调节存在争议,一个主要的原因是拼音文字词长变异大,在考察预视程度时难以克服预视范围的干扰。而中文中词长变化小,能有效分离预视范围与预视程度。利用中文优势,采用眼动技术来考察:(1)副中央凹预加工负荷如何影响预视范围?(2)中央凹加工负荷如何影响预视范围与预视程度?(3)阅读能力与阅读效率如何调节预视范围与预视程度?研究结果将有助于解决副中央凹预视研究中的理论争论,为预测阅读能力与衡量阅读效率提供更多有效的眼动行为指标。

submitted time 2020-02-21 Hits182Downloads51 Comment 0

6. chinaXiv:202002.00037 [pdf]

动作理解因境而异:动作加工中情境信息的自动整合

杨亦松; 林静; 何晓燕; 尹军
Subjects: Psychology >> Cognitive Psychology

针对动作理解的机制,模拟论主张大脑自发模拟他人的动作,就相同的动作其理解也相同,而理论论则认为人们基于合理性原则对他人动作进行推理,相同的动作发生在不同的情境时会有不同的理解。但目前所采用动作材料的运动学特性和发生情境存在共变,其难以区分动作理解是支持模拟论还是理论论。通过两项实验,采用动画制作技术来产生有无约束情境下的追逐动作,以指示动作加工过程的脑电μ抑制为指标,对前述两种观点进行了检验。其中,在约束情境中存在障碍物,追逐者需改变运动方向以绕过障碍物,从后方逐渐趋近目标;而无约束情境中不存在障碍物,但追逐者依然保持与存在约束情景下相同的运动模式。结果发现,当追逐动作发生在存在约束的情境时,其可基于合理性原则推测清晰的动作目标,该条件下的μ抑制程度高于不存在约束情境的条件(实验一);而当仅追逐者运动,即趋近的目标不确定时,虽然有约束和无约束情境间的物理差异与实验一相同,但条件间μ抑制的差异消失(实验二)。其上述μ抑制并非与注意相关的枕叶α活动的泛化。该结果提示,动作发生的情境信息影响人们对动作的理解,即基于推理过程理解动作,支持理论论观点。

submitted time 2020-02-21 Hits173Downloads58 Comment 0

7. chinaXiv:202002.00034 [pdf]

病毒核酸提取前的高温灭活过程显著降低可检出病毒核酸模板量

张沁欣; 赵庆顺
Subjects: Biology >> Molecular Biology

新冠病毒是病毒感染性肺炎(COVID-19)的病原体。然而,新冠病毒核酸临床检出的假阴性率很高。假阴性意味着漏检,不仅会导致疑似患者不能快速确诊,而且会使漏检者成为潜在的病毒传染源。因此,提高新冠病毒核酸检出率十分迫切。目前国家卫健委相关指南要求在提取样本核酸前需将样本置于56℃以上以灭活病毒。这一灭活过程无疑是保护临检人员免受病毒暴露所必需,但也会破坏病毒核酸的完整性,导致部分样品不能被正常检出,成为高假阴性率的原因之一。最近,我们以猪PDEV冠状病毒(疫苗)作为模型研究了高温灭活过程对病毒核酸完整性的影响。结果表明:保存在常用等渗盐溶液Hank’s液中的样品经56℃孵育30分钟后可检出冠状病毒核酸损坏了一半,而以92℃孵育5分钟,则可检出的冠状病毒核酸损失了96%以上。当采用一款市售的R503样品保存液保存PEDV时,经56℃孵育30分钟后病毒核酸可检出量是Hank’s液的3倍,若是92℃孵育5分钟,则可检出量是Hank’s液的42倍。这些结果提示,使用可有效保护样本RNA特别是避免样本RNA在高温灭活时受损的样品保存液,不但可以让临检人员依然能够在高温灭活后使用样品,还有望提高阳性检出率。

submitted time 2020-02-20 Hits1718Downloads504 Comment 0

8. chinaXiv:202002.00036 [pdf]

社会行为的效价信息对注意捕获的影响:基于帮助和阻碍行为的探讨

郑旭涛; 郭文姣; 陈满; 金佳; 尹军
Subjects: Psychology >> Cognitive Psychology

采用学习-测验两任务范式,通过三项实验探讨了社会行为的效价信息对注意捕获的影响。在学习阶段,被试观看具有积极效价的帮助行为(某智能体帮助另一智能体爬山)和消极效价的阻碍行为(某智能体阻碍另一智能体爬山),以及与各自运动特性匹配的无社会交互行为,其目的为建立不同智能体颜色与社会行为效价信息的联结关系。在测验阶段,则分别检验社会行为中的施动方(帮助者和阻碍者)颜色和受动方(被帮助者和被阻碍者)颜色的注意捕获效应。结果发现,消极社会行为中施动方颜色和受动方颜色均更容易捕获注意,而积极社会行为效价信息并没有改变联结特征值的注意捕获效应;且相比于受动方,与消极社会行为效价建立联结的施动方颜色的注意捕获效应更强。该结果提示,存在消极社会行为效价驱动的注意捕获,且消极的效价信息与卷入社会行为所有个体的特征建立联结,但该联结中施动方物理特征具有更高的注意优先性。这一发现暗示,声誉信息与对社会交互行为的整体表征可能综合作用于对社会交互事件的注意选择。

submitted time 2020-02-20 Hits181Downloads62 Comment 0

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