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1. chinaXiv:202002.00063 [pdf]

Perspectives on Active Preventive Measures of Wuhan People against COVID-19 Epidemic at Home: A Comparative Study

zhidong,Xue; Lei,Zhao; Tailang,Yin; Yan,Fu; Zehua,Lyu; yiping,Dang; Yujiang,Zeng; Silou,Huang; Bing,Qu; Hongya,Lyu; Chen,Huang; Zhiyou,Kong; Kepei,Xu; Feipeng,Zhou; Hexun,Dong; He,Hu; Jing,Tang; Senyuan,Xue; Zhixiang,Fang; Jinxiang,Lu
Subjects: Computer Science >> Computer Application Technology

Background:The COVID-19 Epidemic emerged in Wuhan, Hubei province, China. Ever since Wuhan lockdown on January 23rd, mass quarantines were exercised on Wuhan and other epidemic areas of China. We aimed to clarify how ordinary Wuhan people defend against COVID-19 epidemic at home through the Internet survey. Methods:A questionnaire survey, consisting of 30 questions were posted on the Internet. The following aspects were investigated: household preventive measures, self-monitoring of discomfort symptoms, immunity boosting against the epidemic, frequency and reasons of outgoing and mental status of the isolated people. The questionnaire was circulated on Wechat. We marked the areas based on the surveyed network IP addresses and categorized respondents into group A(Wuhan), B(Hubei Province excluding Wuhan ), C, and D based on the epidemic severity of their areas announced by at 17:00 on February 8, 2020. And a comparative study was conducted to illustrate how Wuhan people took the anti-COVID-19 strategies and how efficient these preventive measures were. Findings:In terms of discomfort symptoms, Wuhan, as Group A, had the lowest asymptomatic percentages (70.2%), compared to the average 78.5% (±7%). Considering the three typical symptoms for the COVID-19, i.e., cough, fever and fatigue, Wuhan (9.67%) greatly deviated from the average (7.68%). The fatigue was the most significant factor in the deviation, exceeding the average by 1.35%. In terms of household protection measures, most people or families were able to take effective protection measures with very low frequency of going out, but the percentage of those who took this practice was obviously smaller in Wuhan and Hubei Province. From the aspect of going out, most of the people in Wuhan only went out for shopping and work, with a small number of people for social gathering. In terms of immunity boosting, compared with Group C and D, it was relatively lower in Wuhan. Overall, most people chose to enhance their immunity through regular schedule, exercise, sufficient nutrition. Only 33.44% of people in Group A did not go out, and 59.97% had to go out for living supplies, which was the highest level among the four groups. However, the percentage of people who went out for work and unnecessary activities remains the lowest while 1% of the population went out for public welfare activities, higher than other groups. Worry about the family health topped all the parameters for all the groups. Among them, Wuhan has reached a maximum of 49.61%, higher than the average level of 36.62% (± 10.69%). Mental status except for feeling bored and lonely were the highest in Wuhan. Suggestions:When the epidemic prevention and control is still in a sticky state, and Wuhan started a stricter control measure, the closed management of communities, on Feb 11, 2020, it is expected that our findings can provide some insights into the current household preventive actions and arouse more attentions of the public to some ignored preventive precautions. Unnecessary outgoing should be strictly abandoned. Regular schedule, exercises and nutrition were the top 3 measures participants would choose to enhance their own immunity system. It seems that people in Wuhan would choose nutrition and regular scheduler rather than exercises as the primary immunity-boosting ways. Exercise should be especially advocated as an effective way to enhance the immunity system. In terms of physical condition, people in Wuhan should take more active measures when symptoms occurred. The mentality is also an important aspect requiring intensive attention with the conduct of stricter control management in Wuhan while the rest groups gradually resume to work and ordinary life.

submitted time 2020-02-24 Hits84Downloads22 Comment 0

2. chinaXiv:201904.00073 [pdf]

Prevent culture-driven invasive species spread

Xiong Li; Supriyo Basak; Rui Zhou; Wei-zhe Zhang; Yao Fu; Xin-mao Zhou; Chao Shi; Hou-Cheng Xi; Yong-ping Yang
Subjects: Biology >> Ecology


submitted time 2020-02-24 Hits3633Downloads357 Comment 0

3. chinaXiv:202002.00062 [pdf]

Furin, a potential therapeutic target for COVID-19

Hua Li; Canrong Wu; Yueying Yang; Yang Liu; Peng Zhang; Yali Wang; Qiqi Wang; Yang Xu; Mingxue Li; Mengzhu Zheng; Lixia Chen
Subjects: Medicine, Pharmacy >> Pharmacology

A novel coronavirus (SARS-CoV-2) infectious disease has broken out in Wuhan, Hubei Province since December 2019, and spread rapidly from Wuhan to other areas, which has been listed as an international concerning public health emergency. We compared the Spike proteins from four sources, SARS-CoV-2, SARS-CoV, MERS-CoV and Bat-CoVRaTG13, and found that the SARS-CoV-2 virus sequence had redundant PRRA sequences. Through a series of analyses, we propose the reason why SARS-CoV-2is more infectious than other coronaviruses. And through structure based virtual ligand screening, we foundpotentialfurin inhibitors, which might be used in the treatment of new coronary pneumonia.

submitted time 2020-02-23 Hits650Downloads181 Comment 0

4. chinaXiv:202002.00039 [pdf]


黄发杰; 孟迎芳; 严颖
Subjects: Psychology >> Cognitive Psychology


submitted time 2020-02-22 Hits209Downloads56 Comment 0

5. chinaXiv:202002.00061 [pdf]


Mu, Jingfang; Xu, Jiuyue; Shu, Ting; Wu, Di; Huang, Muhan; Ren, Yujie; Li, Xufang; Geng, Qing; Xu, Yi; Qiu, Yang; Zhou, Xi
Subjects: Biology >> Virology

新型冠状病毒肺炎目前仍在武汉和中国其他地区持续。在目前的形势下,进一步了解新型冠状病毒(SARS-CoV-2)的病毒学和病毒与宿主的相互作用,对控制感染、开发有效的治疗方法具有重要意义。RNA干扰(RNA interference,RNAi)是一种进化上保守的真核生物抗病毒免疫机制,目前已发现许多病毒编码自身的RNA干扰抑制因子作为对抗措施。在这项研究中,我们发现SARS-CoV-2编码的核衣壳蛋白(N)有效地抑制了shRNAs或siRNAs触发的RNAi。此外,与许多由其他病毒编码的VSR类似,SARS-CoV-2的VSR在体外与人类细胞中与dsRNA相互作用,显示出双链RNA(dsRNA)结合活性。综上所述,我们的研究结果表明,SARS-CoV-2的N蛋白在人类细胞中表现出VSR活性,这可能是新型冠状病毒的一个关键免疫逃避因子。

submitted time 2020-02-22 Hits310Downloads95 Comment 0

6. chinaXiv:202002.00038 [pdf]


张慢慢; 臧传丽; 白学军
Subjects: Psychology >> Cognitive Psychology


submitted time 2020-02-21 Hits183Downloads52 Comment 0

7. chinaXiv:202002.00009 [pdf]


全源; 梁峰吉; 熊江辉
Subjects: Biology >> Virology


submitted time 2020-02-21 Hits2359Downloads660 Comment 0

8. chinaXiv:202002.00037 [pdf]


杨亦松; 林静; 何晓燕; 尹军
Subjects: Psychology >> Cognitive Psychology


submitted time 2020-02-21 Hits174Downloads59 Comment 0

9. chinaXiv:202002.00033 [pdf]

Decoding evolution and transmissions of novel pneumonia coronavirus using the whole genomic data

Yu, Wen-Bin; Tang, Guang-Da; Zhang, Li; Corlett, Richard T.
Subjects: Biology >> Virology
Subjects: Biology >> Genetics

Background. The outbreak of COVID-19 started in mid-December 2019 in Wuhan, Central China. Up to February 18, 2020, SARS-CoV-2 has infected more than 70,000 people in China, and another 25 countries across five continents. In this study, we used 93 complete genomes of SARS-CoV-2 from the GISAID EpiFluTM database to decode the evolution and human-to-human transmissions of SARS-CoV-2 in the recent two months. Methods. Alignment of coding-regions was conducted haplotype analyses using DnaSP. Substitution sites were analyzed in codon. Evolutionary analysis of haplotypes used NETWORK. Population size changes were estimated using both DnaSP and Arlequin. Expansion date of population size was calculated based on the expansion parameter tau (τ) using the formula t=τ/2u. Findings. Eight coding-regions have 120 substitution sites, including 79 non-synonymous and 40 synonymous substitutions. Forty-two non-synonymous substitutions changed the biochemical property of amino acids. No evident combination was found. Fifty-eight haplotypes were classified as five groups, and 31 haplotypes were found in samples from both China and other countries, respectively. The rooted network suggested H13 and H35 to be ancestral haplotypes, and H1 (and its descendent haplotypes including all samples from the Hua Nan market) was derived H3 haplotype. Population size of SARS-CoV-2 were estimated to have a recent expansion on 6 January 2020, and an early expansion on 8 December 2019. Interpretation. Genomic variations of SARS-CoV-2 are still low in comparisons with published genomes of SARS-CoV and MERS-CoV. Phyloepidemiologic analyses indicated the SARS-CoV-2 source at the Hua Nan market should be imported from other places. The crowded market boosted SARS-CoV-2 rapid circulations in the market and spread it to the whole city in early December 2019. Furthermore, phyloepidemiologic approaches have recovered specific direction of human-to-human transmissions, and the import sources of international infectious cases.

submitted time 2020-02-21 Hits66332Downloads15228 Comment 0

10. chinaXiv:202002.00034 [pdf]


张沁欣; 赵庆顺
Subjects: Biology >> Molecular Biology


submitted time 2020-02-20 Hits1722Downloads506 Comment 0

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