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1. chinaXiv:201910.00029 [pdf]

Stand up to Action: The Postural Effect on Deontological Responding and the Boundary Condition of Dual Process

刘传军; 廖江群
Subjects: Psychology >> Social Psychology

Present research aimed to uncover a postural effect on deontological responding and its boundary condition of dual process. Previous literatures demonstrated a possibility that people have a stronger controlled cognitive process propensity, thus being less deontological in standing than sitting postures, and that this postural effect can be moderated by dual process. We conducted two studies in which participant read dilemma scenarios and rated the morally acceptance and action intention of the utilitarian proposal after each scenario when sitting or standing. The hypothesized postural effect was verified in a field study (Study 1) and also replicated in an experimental study (Study 2). Compared with those in sitting postures, participants in standing postures approved more to the utilitarian proposal and became less deontological. Furthermore, the postural effect was dismissed when participants made moral decisions with a dual task to increase cognitive load and reversed when participants made moral decisions after deliberate consideration of the sacrificial proposal (Study 2). Thus, the postural effect was stable across field and experimental studies and moderated by dual process. The present research supports and extends the dual process morality theory by confirming that body posture can affect moral decision-making, and also offers a novel evidence confirming the moderating role of dual process on embodiment effects. It enriches our knowledge that morality is evolutionarily embodied in postures and dual process can moderate the embodiment effects.

submitted time 2020-01-14 Hits4026Downloads676 Comment 0

2. chinaXiv:201705.00724 [pdf]

Aromatic Residues in the C-terminal Domain 2 Are Required for Nanog to Mediate LIF-independent Self-renewal of Mouse Embryonic Stem Cells

Wang, Zhe(1.2); Ma, Tianhua; Chi, Xiaoke; Pei, Duanqing
Subjects: Biology >> Biomedical Laboratory Science

Nanog was identified by its ability to sustain the LIF-independent self-renewal of mouse embryonic stem (ES) cells and has recently been shown to play a role in reprogramming adult fibroblasts into pluripotent stem cells. However, little is known about the structural basis of these remarkable activities of Nanog. We have previously identified an unusually strong transactivator named CD2 at its C terminus. Here we demonstrate that CD2 is required for Nanog to mediate ES cell self-renewal. Furthermore, deletion and point mutation analysis revealed that CD2 relies on at least seven aromatic amino acid residues to generate its potent transactivating activity. A mutant Nanog bearing alanine substitutions for these seven residues fails to confer LIF-independent self-renewal in mouse ES cells. Substitution of CD2 by the viral transactivator VP16 gave rise to Nanog-VP16, which is 10 times more active than wild-type Nanog in ES cells. Surprisingly, the expression of Nanog-VP16 in mouse ES cells induces differentiation and is thus unable to sustain LIF-independent self-renewal for mouse ES cells. Taken together, our results demonstrate that the CD2 domain of Nanog is a unique transactivator that utilizes aromatic residues to confer specific activity absolutely required for ES self-renewal.

submitted time 2017-05-10 Hits2193Downloads395 Comment 0

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