分类： 心理学 >> 应用心理学 提交时间： 2017-11-06
摘要： Brain imaging efforts are being increasingly devoted to decode the functioning of the human brain. Among neuroimaging techniques, resting-state fMRI (R-fMRI) is currently expanding exponentially. Beyond the general neuroimaging analysis packages (e.g., SPM, AFNI and FSL), REST and DPARSF were developed to meet the increasing need of user-friendly toolboxes for R-fMRI data processing. To address recently identified methodological challenges of R-fMRI, we introduce the newly developed toolbox, DPABI, which was evolved from REST and DPARSF. DPABI incorporates recent research advances on head motion control and measurement standardization, thus allowing users to evaluate results using stringent control strategies. DPABI also emphasizes test-retest reliability and quality control of data processing. Furthermore, DPABI provides a user-friendly pipeline analysis toolkit for rat/monkey R-fMRI data analysis to reflect the rapid advances in animal imaging. In addition, DPABI includes preprocessing modules for task-based fMRI, voxel-based morphometry analysis, statistical analysis and results viewing. DPABI is designed to make data analysis require fewer manual operations, be less time-consuming, have a lower skill requirement, a smaller risk of inadvertent mistakes, and be more comparable across studies. We anticipate this open-source toolbox will assist novices and expert users alike and continue to support advancing R-fMRI methodology and its application to clinical translational studies.
分类： 心理学 >> 应用心理学 提交时间： 2017-11-06
摘要： Although爈inear trend removing has often been implemented as a routine preprocessing step in resting-state functional magnetic resonance imaging (RS-fMRI) data analysis, the爏patial distribution爋f the magnitude of linear trend is still unclear. Further, it is interesting whether there will be any difference of the linear trend magnitude between different resting-states. For the first aim, we analyzed 5 RS-fMRI datasets from 5 different scanners (namely Beijing-Simens-3T, Cambridge-Siemens-3T, CCBD-GE750-3T, Milwaukee-GE-3T, and Oulu-GE-1.5T). One-sample t-tests on the regression coefficient (i.e., the magnitude of linear trend) were performed for each datasets. For the second aim, we used 2 datasets in each of which different states were compared, one containing eyes-open resting-state (EO-RS) vs. eyes-closed resting-state (EC-RS) and the other containing two steady-state tasks, i.e.,爎eal-time finger force feedback�RT-FFF) and sham finger force feedback (S-FFF) tasks. Paired t-tests were performed between EO-RS and EC-RS, and between RT-FFF and S-FFF. One-sample t-tests showed that the spatial pattern of linear trend of RS-fMRI time series were quite different between different manufactures. The 3T SIEMENS scanners showed positive linear trend in almost all part of the brain, while GE scanners showed primarily negative linear trend in most part of the brain. Paired t-tests showed some differences between paired conditions; differences between EO-RS and EC-RS were mainly in cuneus and eyeballs, and differences between RT-FFF and S-FFF were found in the thalamus, anterior cingulate gyrus, and right sensorimotor cortex. The current study indicated that, while the manufacturer-dependent linear trend of RS-fMRI time series were mostly scanner-related noise, the linear trend may also be physiological noise (eyeballs) or even physiologically meaningful, especially during steady-state tasks.
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