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1. chinaXiv:201703.00308 [pdf]

Target brightness temperature simulation and analysis for the geostationary interferometric microwave sounder (GIMS)

Zhang, Ying; Liu, Hao; Wu, Ji; He, Jieying; Zhang, Cheng
Subjects: Geosciences >> Space Physics

Target brightness temperature maps can be used in geostationary interferometric microwave sounder (GIMS) system simulation. System simulation with accurate target brightness temperature maps can evaluate system performance in near real case and thus help adjust design parameters for the sensor before it is finally put into use. In this paper, method of simulating target brightness temperature using Weather Research and Forecasting Model and Radiative Transfer for TOVS (RTTOV) has been discussed. Target brightness temperature simulation results at oxygen absorption band and water-vapor absorption band have been presented. Some preliminary analyses of simulated brightness temperature for GIMS' observation have also been given.

submitted time 2017-03-10 Hits13021Downloads737 Comment 0

2. chinaXiv:201703.00298 [pdf]

A deblurring method for dynamic target observation of the geostationary interferometric microwave sounder (GIMS)

Zhang, Ying; Liu, Hao; Wu, Ji; Zhang, Cheng; He, Jieying
Subjects: Geosciences >> Space Physics

Brightness temperature change of observation target in one imaging period will introduce image blur to the retrieved image of geostationary interferometric microwave sounder (GIMS), which uses rotating circular array to realize time-sharing sampling other than snap-shot to reduce system complexity but meanwhile resulting in a relatively long imaging period. In this paper, an interpolation method utilizing time sequence of visibilities collected by time-sharing sampling is presented. The method is verified through a simulation system that simulates GIMS's observation process in viewing a series of near real case brightness temperature maps modeled by FNL/WRF/RTTOV method. Results show that the interpolation method can de-blur the image and reduce imaging error to the degree of snap-shot imaging. �2016 IEEE.

submitted time 2017-03-10 Hits1215Downloads385 Comment 0

3. chinaXiv:201703.00291 [pdf]

Analysis and simulation of GIMS observation on dynamic targets

Zhang, Ying; Liu, Hao; Wu, Ji; Zhang, Cheng; He, Jieying
Subjects: Geosciences >> Space Physics

Imaging period is an important consideration to geostationary interferometric microwave sounder (GIMS) when mapping fast changing target such as typhoon. GIMS simulation system with near real case observation target can evaluate system performance in different system configurations and thus help determine the optimal imaging period. In this paper, GIMS simulation system using MATLAB and near real case observation modeled by FNL/WRF/RTTOV method has been used to analyze the effect of imaging period on image quality. System simulation results for each frequency channel will be presented and analyses of imaging period's effect on image quality will also be given. �2016 IEEE.

submitted time 2017-03-10 Hits1164Downloads355 Comment 0

4. chinaXiv:201703.00288 [pdf]

Inter-element phase self-calibration for GIMS (geostationary interferometric microwave sounder)

Han, Donghao; Liu, Hao; Wu, Ji; Zhang, Cheng
Subjects: Geosciences >> Space Physics

The inter-element phase calibration plays an important role in the overall calibration scheme for synthetic aperture radiometer. The traditional relative phase calibration approach is to use correlated noise injection network, which will be difficult to be implemented in millimeter wave band due to the complexity of the waveguide divider network. A novel self-calibration method for interferometric radiometers with rotating thinned array, especially for the geostationary interferometric microwave sounder(GIMS), has been proposed in this paper. By using this approach, neither dedicated hardware nor dedicated calibration working model is needed to achieved the relative phase calibration. The self-calibration approach is inherently merged with the nominal observation working model of GIMS, thanks to the continuous array rotating of GIMS instrument. A running average scheme has been introduced into the self-calibration approach to enhance the SNR of the calibration data, which is normally very low with the natural earth scene. The method is demonstrated by both simulation and field imaging experiment. �2016 IEEE.

submitted time 2017-03-10 Hits647Downloads378 Comment 0

5. chinaXiv:201703.00287 [pdf]

Passive submillimeter-wave imaging demonstrated by a two-element interferometer

Han, Dong-Hao; Liu, Hao; Zhang, De-Hai; Meng, Jin; Zhao, Xin; Zhang, Ying; Wu, Ji
Subjects: Geosciences >> Space Physics

In this paper, an SMMW interferometric radiometer concept is demonstrated by a two-element interferometer with dedicated high accuracy SMMW devices. Point-source calibration method is introduced in order to reduce instrument errors. Interference fringes and point target images are presented by this SMMW interferometer. The linear phase error of the interference fringes is less than 2�and the angular resolution is better than 0.57� The measured performance characteristics of the two-element interferometer are consistent with the theoretical analysis. This interferometer demonstrates a new method for passive SMMW remote sensing. �2016, Science Press. All right reserved.

submitted time 2017-03-10 Hits748Downloads420 Comment 0

6. chinaXiv:201605.01329 [pdf]

A near-infrared phthalocyanine dye-labeled agent for integrin alpha v beta 6-targeted theranostics of pancreatic cancer

Gao, Duo; Gao, Liquan; Zhang, Chenran; Liu, Hao; Jia, Bing; Wang, Fan; Liu, Zhaofei; Gao, Duo; Gao, Liquan; Zhang, Chenran; Liu, Hao; Jia, Bing; Wang, Fan; Liu, Zhaofei; Zhu, Zhaohui; Wang, Fan
Subjects: Biology >> Biophysics >> Imaging Medicine and Biomedical Engineering

Integrin alpha v beta 6 is widely upregulated in variant malignant cancers but is undetectable in normal organs, making it a promising target for cancer diagnostic imaging and therapy. Using streptavidin-biotin chemistry, we synthesized an integrin alpha v beta 6-targeted near-infrared phthalocyanine dye-labeled agent, termed Dye-SA-B-HK, and investigated whether it could be used for cancer imaging, optical imaging-guided surgery, and phototherapy in pancreatic cancer mouse models. Dye-SA-B-HK specifically bound to integrin alpha v beta 6 in vitro and in vivo with high receptor binding affinity. Using small-animal optical imaging, we detected subcutaneous and orthotopic BxPC-3 human pancreatic cancer xenografts in vivo. Upon optical image-guidance, the orthotopically growing pancreatic cancer lesions could be successfully removed by surgery. Using light irradiation, Dye-SA-B-HK manifested remarkable antitumor effects both in vitro and in vivo. F-18-FDG positron emission tomography (PET) imaging and ex vivo fluorescence staining validated the observed decrease in proliferation of treated tumors by Dye-DA-B-HK phototherapy. Tissue microarray results revealed overexpression of integrin alpha v beta 6 in over 95% cases of human pancreatic cancer, indicating that theranostic application of Dye-DA-B-HK has clear translational potential. Overall, the results of this study demonstrated that integrin alpha v beta 6-specific Dye-SA-B-HK is a promising theranostic agent for the management of pancreatic cancer. (C) 2015 Elsevier Ltd. All rights reserved.

submitted time 2016-05-11 Hits769Downloads482 Comment 0

7. chinaXiv:201605.01245 [pdf]

Serial in Vivo Imaging Using a Fluorescence Probe Allows Identification of Tumor Early Response to Cetuximab Immunotherapy

Ma, Teng; Liu, Hao; Sun, Xianlei; Gao, Liquan; Shi, Jiyun; Zhao, Huiyun; Jia, Bing; Wan, Fan; Liu, Zhaofei; Ma, Teng; Liu, Hao; Sun, Xianlei; Gao, Liquan; Jia, Bing; Wan, Fan; Liu, Zhaofei; Shi, Jiyun; Zhao, Huiyun
Subjects: Biology >> Biophysics

Cetuximab is an antiepidermal growth factor receptor (EGFR) monoclonal antibody that has received the approval of the Food and Drug Administration (FDA) for cancer treatment. However, most clinical studies indicate that cetuximab can only elicit positive effects on a subset of cancer patients. In this study, we investigated whether near-infrared fluorescence (NIRF) imaging of tumor vascular endothelial growth factor (VEGF) expression could be a biomarker for tumor early response to cetuximab therapy in preclinical wild-type and mutant tumor models of the KRAS gene. The treatment efficacy of cetuximab was determined in both HT-29 (wild-type KRAS) and HTC-116 (mutant KRAS) human colon cancer models. A VEGF-specific optical imaging probe (Dye755-Ran) was synthesized by conjugating ranibizumab (an anti-VEGF antibody Fab fragment) with a NIRF dye. Serial optical scans with Dye755-Ran were performed in HT-29 and HTC-116 xenograft models. By using longitudinal NIRF imaging, we were able to detect early tumor response on day 3 and day 5 after initiation of cetuximab treatment in the cetuximab-responsive HT-29 tumor model. Enzyme-linked immunosorbent assay (ELISA) confirmed that cetuximab treatment inhibited human VEGF expression in the KRAS wild-type HT-29 tumor but not in the KRAS mutant HCT-116 tumor. We have demonstrated that the antitumor effect of cetuximab can be noninvasively monitored by serial fluorescence imaging using Dye755-Ran. VEGF expression detected by optical imaging could serve as a sensitive biomarker for tumor early response to drugs that directly or indirectly act on VEGF.

submitted time 2016-05-11 Hits548Downloads314 Comment 0

8. chinaXiv:201605.00767 [pdf]

Inhibition of tumor growth and metastasis by photoimmunotherapy targeting tumor-associated macrophage in a sorafenib-resistant tumor model

Zhang, Chenran; Gao, Liquan; Liu, Hao; Gao, Duo; Lai, Jianhao; Jia, Bing; Wang, Fan; Liu, Zhaofei; Zhang, Chenran; Gao, Liquan; Liu, Hao; Gao, Duo; Lai, Jianhao; Jia, Bing; Wang, Fan; Liu, Zhaofei; Cai, Yuehong; Wang, Fan;
Subjects: Biology >> Biophysics >> Imaging Medicine and Biomedical Engineering

Tumor-associated macrophages (TAMs) play essential roles in tumor invasion and metastasis, and contribute to drug resistance. Clinical evidence suggests that TAM levels are correlated with local tumor relapse, distant metastasis, and poor prognosis in patients. In this study, we synthesized a TAM-targeted probe (IRD-alpha CD206) by conjugating a monoclonal anti-CD206 antibody with a near-infrared phthalocyanine dye. We then investigated the potential application of the IRD-alpha CD206 probe to near-infrared fluorescence (NIRF) imaging and photoimmunotherapy (PIT) of tumors resistant to treatment with the kinase inhibitor sorafenib. Sorafenib treatment had no effect on tumor growth in a 4T1 mouse model of breast cancer, but induced M2 macrophage polarization in tumors. M2 macrophage recruitment by sorafenib-treated 4T1 tumors was noninvasively visualized by in vivo NIRF imaging of IRD-alpha CD206. Small-animal single-photon emission computed tomography (SPECT)/CT and intratumoral micro distribution analysis indicated TAM-specific localization of the IRD-alpha CD206 probe in 4T1 tumors after several rounds of sorafenib treatment. Upon light irradiation, IRD-alpha CD206 suppressed the growth of sorafenib-resistant tumors. In vivo CT imaging and ex vivo histological analysis confirmed the inhibition of lung metastasis in mice by IRD-alpha CD206 PIT. These results demonstrate the utility of the IRD-alpha CD206 probe for TAM-targeted diagnostic imaging and treatment of tumors that are resistant to conventional therapeutics. (C) 2016 Elsevier Ltd. All rights reserved.

submitted time 2016-05-05 Hits1086Downloads791 Comment 0

9. chinaXiv:201605.00283 [pdf]

TARGET BRIGHTNESS TEMPERATURE SIMULATION AND ANALYSIS FOR THE GEOSTATIONARY INTERFEROMETRIC MICROWAVE SOUNDER (GIMS)

Zhang, Ying; Liu, Hao; Wu, Ji; He, Jieying; Zhang, Cheng
Subjects: Geosciences >> Space Physics

Target brightness temperature maps can be used in geostationary interferometric microwave sounder (GIMS) system simulation. System simulation with accurate target brightness temperature maps can evaluate system performance in near real case and thus help adjust design parameters for the sensor before it is finally put into use. In this paper, method of simulating target brightness temperature using Weather Research and Forecasting Model and Radiative Transfer for TOVS (RTTOV) has been discussed. Target brightness temperature simulation results at oxygen absorption band and water-vapor absorption band have been presented. Some preliminary analyses of simulated brightness temperature for GIMS' observation have also been given.

submitted time 2016-05-03 Hits559Downloads361 Comment 0

10. chinaXiv:201605.00282 [pdf]

IMAGING SIMULATION OF THE MICROWAVE RADIOMETER ABOARD THE MICAP FOR SEA SURFACE SALINITY MEASUREMENT

Zhang, Cheng; Liu, Hao; Wu, Lin; Wu, Ji
Subjects: Geosciences >> Space Physics

Sea surface salinity as an ocean variable plays an important role in various components of the water and energy cycle. Recently a Chinese space mission using a new concept of Microwave Imager Combined Active and Passive (MICAP) at L-band is proposed for the ocean salinity measurement. MICAP uses interferometric techniques for both the radiometer and the scatterometer, which adopt two kinds of linear array feeds sharing one 3x4.5 m parabolic cylinder reflector. This paper is focused on the microwave interferometric radiometer (MIR) aboard the MICAP, and discusses the imaging simulation, imaging algorithm, and instrument performance.

submitted time 2016-05-03 Hits591Downloads351 Comment 0

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