您当前的位置:首页 > 论文浏览
您选择的条件: 神经生物学(3)

1. chinaXiv:201803.00583 [pdf]

基于静息态fMRI的催眠控制呼吸研究

刘燕君; 李荣茂; 臧珊珊; 陈思宇; 谢耀钦
分类: 生物学 >> 神经生物学
分类: 工程与技术科学 >> 生物医学工程学

催眠是一种被证明有效的、无害的心理学上的呼吸控制方法。文章通过对 13 位有催眠背景的心理咨询师被试进行催眠控制呼吸实验,由催眠师引导被试进行催眠,运用静息态功能磁共振的方法来研究催眠控制呼吸状态下脑功能的异常。结果显示:在催眠状态下,脑活动在视觉皮层(枕叶)、感觉运动皮层(中央前回、中央后回、布洛德曼 4、6 区)、后扣带回以及颞中回上升;在背外侧前额皮层、小脑后叶以及缘上回下降,并且在全脑大规模静息态功能网络范围内相关关系增强(正常态 r=0.64,催眠态 r=0.80)。此外,催眠状态下视觉皮层与运动皮层之间的功能连接增强。研究结果表明,视觉皮层和运动皮层在催眠控制呼吸的神经机制中发挥了重要的作用,其神经机制也可能与认知处理和感知处理密切相关。本研究结合了心理学以及脑科学进行了研究,为催眠的研究提供了一个认知脑科学的研究新视觉。

提交时间: 2018-03-15 点击量1387下载量834 评论 0

2. chinaXiv:201703.01054 [pdf]

Impaired spinal glucocorticoid receptor signaling contributes to the attenuating effect of depression on mechanical allodynia and thermal hyperalgesia in rats with neuropathic pain

Wei, Xiao; Sun, Yuqi; Luo, Fei
分类: 生物学 >> 神经生物学

Although depression-induced altered pain perception has been described in several laboratory and clinical studies, its neurobiological mechanism in the central nervous system, particularly in the spinal dorsal horn remains unclear. In this study, we therefore aimed to clarify whether nociceptive sensitivity of neuropathic pain is altered in the olfactory bulbectomy (OB) model of depression and whether glucocorticoid receptor (GR), which is involved in the etio-pathologic mechanisms of both major depression and neuropathic pain, contributes to these processes in the spinal dorsal horn of male Sprague-Dawley rats. The results showed that mechanical allodynia and thermal hyperalgesia induced by spinal nerve ligation (SNL) were attenuated in OB-SNL rats with decreased spinal GR expression and nuclear translocation, while NOB (non-olfactory bulbectomy)-SNL rats showed an increased spinal GR nuclear translocation. Decreased GR nuclear translocation with normal mechanical nociception and hypoalgesia of thermal nociception were observed in OB-Sham rats, too. Intrathecal injection of GR agonist dexamethasone (4 µg / rat / day for 1 week) eliminated the attenuating effect of depression on the nociceptive hypersensitivity in OB-SNL rats and aggravated neuropathic pain in NOB-SNL rats, associating with the up-regulation of BDNF, TrkB and NR2B expression in the spinal dorsal horn. The present study shows that depression attenuates the mechanical allodynia and thermal hyperalgesia of neuropathic pain and suggests that altered spinal GR-BDNF-TrkB signaling may be one of the reasons for depression-induced hypoalgesia.

提交时间: 2017-07-24 点击量2035下载量712 评论 0

3. chinaXiv:201703.01054 [pdf]

Impaired spinal glucocorticoid receptor signaling contributes to the attenuating effect of depression on mechanical allodynia and thermal hyperalgesia in rats with neuropathic pain

Wei, Xiao; Sun, Yuqi; Luo, Fei
分类: 生物学 >> 神经生物学

Although depression-induced altered pain perception has been described in several laboratory and clinical studies, its neurobiological mechanism in the central nervous system, particularly in the spinal dorsal horn remains unclear. In this study, we therefore aimed to clarify whether nociceptive sensitivity of neuropathic pain is altered in the olfactory bulbectomy (OB) model of depression and whether glucocorticoid receptor (GR), which is involved in the etio-pathologic mechanisms of both major depression and neuropathic pain, contributes to these processes in the spinal dorsal horn of male Sprague-Dawley rats. The results showed that mechanical allodynia and thermal hyperalgesia induced by spinal nerve ligation (SNL) were attenuated in OB-SNL rats with decreased spinal GR expression and nuclear translocation, while NOB (non-olfactory bulbectomy)-SNL rats showed an increased spinal GR nuclear translocation. Decreased GR nuclear translocation with normal mechanical nociception and hypoalgesia of thermal nociception were observed in OB-Sham rats, too. Intrathecal injection of GR agonist dexamethasone (4 µg / rat / day for 1 week) eliminated the attenuating effect of depression on the nociceptive hypersensitivity in OB-SNL rats and aggravated neuropathic pain in NOB-SNL rats, associating with the up-regulation of BDNF, TrkB and NR2B expression in the spinal dorsal horn. The present study shows that depression attenuates the mechanical allodynia and thermal hyperalgesia of neuropathic pain and suggests that altered spinal GR-BDNF-TrkB signaling may be one of the reasons for depression-induced hypoalgesia.

提交时间: 2017-03-31 点击量1879下载量560 评论 0

  [1 页/ 3 条记录]