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1. chinaXiv:202003.00024 [pdf]

梓醇全丙酰化产物的微波合成及其神经保护作用初探

程晓东; 张秋霞; 李振兴; 董春红; 蒋士卿; 孙雨安; 王国庆
Subjects: Chemistry >> Applied Chemistry

[目的] 微波辅助合成具有潜在神经保护作用的梓醇全丙酰化产物(CP-6)。 [方法] 以梓醇、丙酰酐为原料,吡啶为溶剂和缚酸剂,微波辅助合成梓醇全丙酰化衍生物。CP-6经FT-IR、HRMS、NMR表征,采用MTT法筛查其神经保护活性。 [结果] 当丙酸酐与梓醇摩尔比为18,微波反应器反应温度 80 ℃,反应时间6 h, 梓醇在吡啶中浓度 25 g/L时梓醇全丙酰化产物产率可达98.51%。CP-6具有潜在的神经保护活性。 [结论] CP-6可经微波合成制得,其具有神经保护作用,是一种潜在的神经保护作用药物。

submitted time 2020-03-05 Hits1336Downloads502 Comment 0

2. chinaXiv:201710.00012 [pdf]

Four new ent-kaurene diterpene glucosides from Mikania micrantha

Dong, Limei; Jia, Xuchao; Luo, Qingwen; Peng, Yiming; Zhang, Qiang; Luo, Bi; Tan, jianwen
Subjects: Chemistry >> Applied Chemistry

Phytochemical study on the aerial parts of Mikania micrantha led to the isolation of four new ent-kaurene diterpene glucosides, β-D-glucopyranosyl-15α-(3-hydroxy-3-methylbutanoyloxy)-9β-hydroxy-ent-16-kauren-19-oate (1), β-D-glucopyranosyl-15α-(3-methylbutanoyloxy)-9β-hydroxy-ent-16-kauren-19-oate (2), β-D-glucopyranosyl-15α-(2-methylbutanoyloxy)-9β-hydroxy-ent-16-kauren-19-oate (3), β-D-glucopyranosyl-15α-(3-methyl-2-butenoyloxy)-9β-hydroxy-ent-16-kauren-19-oate (4), along with a known one, β-D-glucopyranosyl-15α-(3-hydroxy-3-methylbutanoyloxy)-ent-16-kauren-19-oate (5). Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1–4 are a group of C-9 hydroxylated ent-kaurene diterpene glucosides which is relatively rare in nature. These compounds selectively showed in vitro antibacterial activity against four assayed Gram-(+) and three Gram-(-) bacteria. In addition, the in vitro growth inhibitory activity of these compounds against human cancer cell lines Hela, A549, HepG-2 and MCF-7, were also tested.

submitted time 2017-10-17 Hits2715Downloads1217 Comment 0

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