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1. chinaXiv:201612.00466 [pdf]

Realistic Flipped SU(5) from Orbifold SO(10)

Balazs,C; Kang,Z; Li,T; Wang,F; Yang,JM

We propose a realistic flipped SU(5) model derived from a five-dimensional orbifold SO(10) model. The Standard Model (SM) fermion masses and mixings are explained by combining the traditional Froggatt-Nielsen mechanism with the five-dimensional wave funct

submitted time 2016-12-28 Hits2267Downloads1388 Comment 0

2. chinaXiv:201612.00454 [pdf]

Semi-direct Gauge-Yukawa Mediation

Kang,Z; Li,T; Liu,T; Yang,JM

We propose semi-direct Gauge-Yukawa mediation of supersymmetry (SUSY) breaking. The messenger fields mediating SUSY breaking to the visible sector do not directly couple with the goldstino field, and instead they have gauge and Yukawa interactions with so

submitted time 2016-12-28 Hits1479Downloads751 Comment 0

3. chinaXiv:201612.00444 [pdf]

The Minimal Solution to the mu/B_mu Problem in Gauge Mediation

Kang,Z; Li,T; Liu,T; Yang,JM

We provide a minimal solution to the mu/B_mu problem in the gauge mediated supersymmetry breaking by introducing a Standard Model singlet filed S with a mass around the messenger scale which couples to the Higgs and messenger fields. This singlet is nearl

submitted time 2016-12-28 Hits1438Downloads765 Comment 0

4. chinaXiv:201612.00395 [pdf]

750 GeV diphoton resonance, 125 GeV Higgs and muon g ? 2 anomaly in deflected anomaly mediation SUSY breaking scenarios

Wang,F; Wu,L; Yang,JM; Zhang,M

We propose to interpret the 750 GeV diphoton excess in deflected anomaly mediation supersymmetry breaking scenarios, which can naturally predict couplings be- tween a singlet field and vector-like messengers. The CP-even scalar component (S) of the singlet field can serve as the 750 GeV resonance. The messenger scale, which is of order the gravitino scale, can be as light as Fφ ? O(10) TeV when the messenger species NF and the deflection parameter d are moderately large. Such messengers can induce the large loop decay process S → γγ. Our results show that such a scenario can successfully accommo- date the 125 GeV Higgs boson, the 750 GeV diphoton excess and the muon g ? 2 without conflicting with the LHC constraints. We also comment on the possible explanations in the gauge mediation supersymmetry breaking scenario.

submitted time 2016-12-28 Hits1377Downloads786 Comment 0

5. chinaXiv:201612.00345 [pdf]

Realistic Flipped SU(5) from Orbifold SO(10)

Balazs,C; Kang,Z; Li,T; Wang,F; Yang,JM

We propose a realistic flipped SU(5) model derived from a five-dimensional orbifold SO(10) model. The Standard Model (SM) fermion masses and mixings are explained by combining the traditional Froggatt-Nielsen mechanism with the five-dimensional wave funct

submitted time 2016-12-28 Hits1319Downloads746 Comment 0

6. chinaXiv:201612.00246 [pdf]

Radiative natural SUSY spectrum from deflected AMSB scenario with messenger-matter interactions

Wang,F; Yang,JM; Zhang,Y

A radiative natural SUSY spectrum are proposed in the deflected anomaly mediation scenario with general messenger-matter interactions. Due to the contributions from the new interactions, positive slepton masses as well as a large |Att_{t} | term can natur

submitted time 2016-12-27 Hits955Downloads518 Comment 0

7. chinaXiv:201605.01534 [pdf]

Recent Progress and Challenges in High Throughput RNA Methylation Sequencing Data Analysis

Liu Lian; Zhang Shao-Wu; Chen Run-Sheng; Meng Jia; Chen Run-Sheng
Subjects: Biology >> Biophysics >> Biochemistry & Molecular Biology

With the rapid development of high-throughput sequencing technologies, the emerging of methylated RNA immunoprecipitation sequencing (MeRIP-seq) technology makes it possible to detect RNA epigenetic modifications in a large scale, which allows transcriptome-wide profiling of RNA methylation. Mining the patterns of global mRNA methylation from these MeRIP-seq data can help reveal the potential functional roles of these mRNA methylations in regulating gene expression, splicing, RNA editing and RNA stability, effectively guiding the therapeutic intervention of cancer. Here, the principle of MeRIP-seq sequencing was first introduced. Then, the recent progress of the processing and analysis of MeRIP-seq data were comprehensively discussed. In the end, the computational problems and challenges faced in the process of MeRIP-seq data processing were also summarized.

submitted time 2016-05-12 Hits13205Downloads2588 Comment 0

8. chinaXiv:201605.01462 [pdf]

HIV-1 Exploits the Host Factor RuvB-like 2 to Balance Viral Protein Expression

Mu, Xin; Wang, Xinlu; Xuan, Yifang; Gao, Guangxia; Fu, Yajing; Shang, Hong; Zhu, Yiping; Goff, Stephen P.; Zhu, Yiping; Goff, Stephen P.
Subjects: Biology >> Biophysics

The correct ratio of the HIV-1 structural protein Gag to the envelope protein (Env) is important for maximal virion infectivity. How the virus ensures the production of Gag and Env proteins in an appropriate ratio remains unknown. We report that HIV-1 exploits the host factor RuvB-like 2 (RVB2) to balance relative expression of Gag and Env for efficient production of infectious virions. RVB2 inhibits Gag expression by interacting with both the encoded Matrix (MA) domain of Gag protein and 5' UTR of the translating mRNA and promoting mRNA degradation in a translation-dependent manner. This inhibitory activity of RVB2 is antagonized by Env through competitive interaction with MA, allowing Gag synthesis to proceed when Env levels are adequate for virion assembly. In HIV-1-positive patients, RVB2 levels positively correlate with viral loads and disease progression status. These findings reveal a mechanism by which HIV-1 regulates its protein expression.

submitted time 2016-05-12 Hits745Downloads398 Comment 0

9. chinaXiv:201605.01430 [pdf]

CUG-BP1 regulates RyR1 ASI alternative splicing in skeletal muscle atrophy

Tang, Yinglong; Wang, Huiwen; Gu, Lei; Yang, Zhiguang; Wu, Yanyun; Yuan, Qi; Ji, Guangju; Wei, Bin; Tang, Yinglong; Guo, Yuting; Gu, Lei; Yang, Zhiguang; Zhao, Gang; Zhang, Qing
Subjects: Biology >> Biophysics

RNA binding protein is identified as an important mediator of aberrant alternative splicing in muscle atrophy. The altered splicing of calcium channels, such as ryanodine receptors (RyRs), plays an important role in impaired excitation-contraction (E-C) coupling in muscle atrophy; however, the regulatory mechanisms of ryanodine receptor 1 (RyR1) alternative splicing leading to skeletal muscle atrophy remains to be investigated. In this study we demonstrated that CUG binding protein 1 (CUG-BP1) was up-regulated and the alternative splicing of RyR1 ASI (exon70) was aberrant during the process of neurogenic muscle atrophy both in human patients and mouse models. The gain and loss of function experiments in vivo demonstrated that altered splicing pattern of RyR1 ASI was directly mediated by an up-regulated CUG-BP1 function. Furthermore, we found that CUG-BP1 affected the calcium release activity in single myofibers and the extent of atrophy was significantly reduced upon gene silencing of CUG-BP1 in atrophic muscle. These findings improve our understanding of calcium signaling related biological function of CUG-BP1 in muscle atrophy. Thus, we provide an intriguing perspective of involvement of mis-regulated RyR1 splicing in muscular disease.

submitted time 2016-05-12 Hits1102Downloads632 Comment 0

10. chinaXiv:201605.01428 [pdf]

Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 angstrom Resolution

Chang, Shenghai; Sun, Dapeng; Liang, Huanhuan; Li, Jun; Guo, Lu; Wang, Xiangli; Guan, Chengcheng; Boruah, Bhargavi M.; Yuan, Lingmin; Feng, Feng; Yang, Mingrui; Liu, Yingfang; Wang, Jia; Wang, Jiawei; Wang, Hong-Wei; Wojdyla, Justyna; Wang, Meitian; Li, Lanjuan; Liu, Yingfang; Wang, Lulan
Subjects: Biology >> Biophysics >> Biochemistry & Molecular Biology

Replication and transcription of influenza virus genome mainly depend on its RNA-dependent RNA polymerase (RdRP), composed of the PA, PB1, and PB2 subunits. Although extensively studied, the underlying mechanism of the RdRP complex is still unclear. Here we report the biochemical characterization of influenza RdRP subcomplex comprising PA, PB1, and N terminus of PB2, which exist as dimer in solution and can assemble into a tetramer state, regulated by vRNA promoter. Using single-particle cryo-electron microscopy, we have reconstructed the RdRP tetramer complex at 4.3 angstrom, highlighting the assembly and interfaces between monomers within the tetrameric structure. The individual RdRP subcomplex contains all the characterized motifs and appears as a cage-like structure. High-throughput mutagenesis profiling revealed that residues involved in the oligomer state formation are critical for viral life cycle. Our results lay a solid base for understanding the mechanism of replication of influenza and other negative-stranded RNA viruses.

submitted time 2016-05-12 Hits1040Downloads565 Comment 0

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