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1. chinaXiv:202112.00038 [pdf]


邓尧; 王梦梦; 饶恒毅
Subjects: Psychology >> Cognitive Psychology

仿真气球冒险任务(The Balloon Analog Risk Task, BART)能在实验室环境下模拟真实世界的风险情境,具有高生态性,稳定性和可靠性等优点,已经成为风险决策研究的中最常用的实验范式之一。近年来,研究者发展了多种BART变体范式,对发展、健康以及精神病理等多领域的风险决策行为及其神经基础开展了广泛探索。BART任务中的风险决策加工与腹侧纹状体、前扣带皮层、脑岛、中脑及背外侧前额叶等脑区的激活相关。未来研究需要进一步完善BART任务在风险决策认知神经领域的信效度并扩展BART的应用情境。

submitted time 2021-12-03 Hits6241Downloads612 Comment 0

2. chinaXiv:201605.00746 [pdf]

Resting-state functional connectivity between the dorsal anterior cingulate cortex and thalamus is associated with risky decision-making in nicotine addicts

Wei, Zhengde; Yang, Nannan; Yang, Lizhuang; Wang, Ying; Han, Long; Zha, Rujing; Huang, Ruiqi; Zhou, Yifeng; Liu, Ying; Zhang, Peng; Zhang, Xiaochu; Zhang, Xiaochu; Zhang, Xiaochu;
Subjects: Biology >> Biophysics

Nicotine addiction is associated with risky behaviors and abnormalities in local brain areas related to risky decision-making such as the dorsal anterior cingulate cortex (dACC), anterior insula (AI), and thalamus. Although these brain abnormalities are anatomically separated, they may in fact belong to one neural network. However, it is unclear whether circuit-level abnormalities lead to risky decision-making in smokers. In the current study, we used task-based functional magnetic resonance imaging (fMRI) and examined resting-state functional connectivity (RSFC) to study how connectivity between the dACC, insula, and thalamus influence risky decision-making in nicotine addicts. We found that an increase in risky decision-making was associated with stronger nicotine dependence and stronger RSFC of the dACC-rAI (right AI), the dACC-thalamus, the dACC-lAI (left AI), and the rAI-lAI, but that risky decision-making was not associated with risk level-related activation. Furthermore, the severity of nicotine dependence positively correlated with RSFC of the dACC-thalamus but was not associated with risk level-related activation. Importantly, the dACC-thalamus coupling fully mediated the effect of nicotine-dependent severity on risky decision-making. These results suggest that circuit-level connectivity may be a critical neural link between risky decision-making and severity of nicotine dependence in smokers.

submitted time 2016-05-05 Hits1649Downloads901 Comment 0

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