分类： 生物学 >> 生物物理学 分类： 材料科学 >> 生物材料 分类： 化学 >> 化学生物学 分类： 医学、药学 >> 基础医学 提交时间： 2023-02-09
Nanotechnology has provided considerable promise for the biological and medical fields, especially in the subjects of biological and medical imaging for the last two decades. Here, we outline different nanoparticles to contribute to biological and medical imaging disciplines. These concerned nanoparticles are soft nanoparticles, which are based on biomacromolecule/polymer or organic molecule components, hard nanoparticles that are derived from various inorganic components and hard-soft nanoparticles that are based on both inorganic components and biomacromolecule/polymer or organic molecule ones. We also discuss the imaging modalities in biology and medicine that various nanoparticles became involved in are: (1) optical imaging (OI), (2) computed tomography (CT), (3) magnetic resonance imaging (MRI), (4) ultrasonography (USG), (5) positron emission tomography (PET). We will also describe various nanoparticles to serve for one/some of those five modalities in biology and medicine imaging in this review paper.
分类： 化学 >> 应用化学 提交时间： 2020-03-05
摘要：[目的] 微波辅助合成具有潜在神经保护作用的梓醇全丙酰化产物（CP-6）。 [方法] 以梓醇、丙酰酐为原料，吡啶为溶剂和缚酸剂，微波辅助合成梓醇全丙酰化衍生物。CP-6经FT-IR、HRMS、NMR表征，采用MTT法筛查其神经保护活性。 [结果] 当丙酸酐与梓醇摩尔比为18，微波反应器反应温度 80 ℃，反应时间6 h, 梓醇在吡啶中浓度 25 g/L时梓醇全丙酰化产物产率可达98.51%。CP-6具有潜在的神经保护活性。 [结论] CP-6可经微波合成制得，其具有神经保护作用，是一种潜在的神经保护作用药物。
分类： 化学 >> 化学物理学 提交时间： 2018-11-28
Taixiang Liu
Ke Yang
Zhuo Zhang
Lianghong Yan
Beicong Huang
Heyang Li
Chuanchao Zhang
Xiaodong Jiang
Hongwei Yan
摘要：Large-scale, high-power laser facility is currently a basis for the research of inertial confinement fusion (ICF). In the laser facility, fused silica optics plays irreplaceable role to conduct extremely high-intensity ultraviolet laser to fusion target. However, the surface fractures, such as surface pit, crack, scratch, and laser damage site, of the optics will lower the beam quality of transmitted laser, weaken the laser damage-resistance, shorten the lifetime of the optics, and thus limit the output performance of the laser facility. In this work, to mitigate the surface fractures, hydrofluoric acid-based (HF-based) etching effect on the surface fractures is experimentally and theoretically studied. From the experimental study, with the result of three-dimensional (3D) morphological evolution of surface fractures, it is shown that the surface fractures will be passivated and their profiles will get smoothed after etching, indicating HF-based etching is a promising way to improve the local surface quality of the fractures. Especially, it is found HF-based etching can greatly suppress the laser damage growth of laser damage site by mitigating its surface and subsurface fractures, and thus is a promising wet chemical method for repairing laser-induced damage optics. In the theoretical study, an explicit local-curvature dependent etching model is proposed. Based on this model, the result from finite difference time domain (FDTD) simulation agrees very well with that of experiment, which can reveal the detailed physical process of HF-based etching. It is demonstrated that the FDTD simulation can be a reliable and efficient way to predict the morphological evolution of the surface fractures during etching.
分类： 化学 >> 无机化学 提交时间： 2018-10-04
Chao, Zhao
Can, Xiong
Man, Qiao
Tongwei, Yuan
Jing, Wang
Yunteng, Qu
XiaoQian, Wang
Fangyao, Zhou
Zhijun, Li
Qian, Xu
Shiqi, Wang
Min, Chen
Wenyu, Wang
Yafei, Li
Yuen, Wu
Yadong, Li
摘要：在这里，我们报告了一种高温气体迁移策略来制备多相的单原子铁催化剂，并展示其优良的类天然酶的活性（定义为单原子酶，SAE）。 结果表明，Fe SAE的局部定义明确的FeN4位点与含血红素的天然酶的活性金属中心高度相似。 Fe SAE表现出超级高的类过氧化物酶，氧化酶和过氧化氢酶的活性，超过了Fe3O4纳米酶40倍。更重要的是，Fe SAE可以有效活化过氧化氢（H2O2）产生羟基自由基（•OH）。 这使得其可以作为一种多相化的类Fenton系统，可以应对不断增加的环境污染。 我们的研究结果开辟了一个新的人造材料家族-模仿天然
分类： 物理学 >> 原子与分子物理学 分类： 化学 >> 化学物理学 提交时间： 2018-05-19
见英文摘要
分类： 化学 >> 物理化学 提交时间： 2017-11-05 合作期刊: 《结构化学》
摘要：In order to enhance water-solubility and biological utilization rate of tectochrysin, sodium 5-hydroxyl-7-methoxyflavone-6-sulfonate (1) was synthesized and its structure was identified on the basis of 1H NMR, FT-IR and elemental analysis. 5-Hydroxyl-7-methoxyflavone-6-sulfonate was assembled with Ni(II) or Mn(II), hexaquanickel(II) bis(5-hydroxyl-7-methoxyflavone-6-sulfonate) tetrahydrate (2) and hexaquamanganese(II) bis(5-hydroxyl-7-methoxyflavone-6-sulfonate) tetrahydrate (3) were obtained and characterized by IR spectroscopy. The crystal structures of 2 and 3 were determined by X-ray single-crystal diffraction analysis. The results showed that 2 and 3 are isomorphous crystals and crystallize in monoclinic crystal system, space group C2/c. In 2 and 3, the supramolecular structures are organized into hydrophilic and hydrophobic regions. Hydrophilic regions are generated by O–H×××O hydrogen bonds among sulfonate groups, latticed water molecules and coordinated water molecules. The π-π stacking interactions assemble the flavone skeletons into columns and these columns form hydrophobic regions. The sulfonate groups play an important role as a bridge of the hydrophilic and hydrophobic regions as well as the inorganic and organic components. Three-dimensional networks of 2 and 3 are furnished by extensive array of hydrogen bonds, π-π stacking interactions and electrostatic interactions. The anti-proliferative activities of 1～3 in vitro against human leukemia cells K562 and human lung cancer cells A549 were evaluated by the standard MTT assay. The pharmacological activity results showed that the introduction of sulfonic acid groups enhanced the antitumor activity of tectochrysin.
分类： 化学 >> 物理化学 提交时间： 2017-11-05 合作期刊: 《结构化学》
摘要：Fortunella margarita (Lour.) Swingle, commonly known as kumquat, is the smallest citrus fruit. It thrives in southeastern China and is widely cultivated and consumed in the world due to its multiple health benefits. It has been used as an important herbal medicine in traditional Chinese medicine and also as one of the most popular fruits. There are various kinds of bioactive compounds in F. margarita, such as polysaccharides, limonoids, essential oils, flavonoids, phenolic acids, vitamins, dietary fiber, etc. In addition, many studies have reported that these bioactive compounds can be used as antioxidant, antimicrobial, hypolipidemic, drosophila lure components in functional foods, pharmaceuticals and daily chemical products due to their biological activities. This review focuses on the structural features and biological activities of polysaccharides, limonoids, essential oils and flavonoids and other bioactive substances from F. margarita and their potential applications in food, daily chemical and pharmaceutical industries.
分类： 化学 >> 物理化学 提交时间： 2017-11-05 合作期刊: 《结构化学》
摘要：Two new coordination polymers, namely, {[Cd1.5(bc)2(HL)].H2O}2n (1) and [Mn(ip)(H2L)(H2O)]n (2) (H2L = 3-(1H-pyrazol-4-yl)-5-(pyridin-2-yl)-1,2,4-triazole, Hbc = benzoic acid, H2ip = isophthalic acid) were constructed by solvothermal reaction. The compounds were characterized by elemental analysis, FT-IR spectroscopy, and single-crystal X-ray diffraction. Compound 1 displays a two-dimensional plane structure consisting of [Cd3(bc)2(HL)] subunits. Compound 2 possesses a one-dimensional chain structure and is further extended into a 3-D supramolecular architecture via hydrogen bonds. Moreover, photoluminescence studies showed compound 1 exhibits luminescent emissions with emission maxima at 375 nm. Magnetic susceptibility measurements of 2 indicate that domain antiferromagnetic interactions exist between Mn(II) ions. In addition, thermogravimetric properties of 1 and 2 were also measured.
分类： 化学 >> 物理化学 提交时间： 2017-11-05 合作期刊: 《结构化学》
摘要：Two new complexes [Ag(bix)]n·nNAA·nH2O (1) and [Cd(NAA)(phen)2(H2O)]2·2CH3COO-·H2O (2) (bix = 1,4-bis(imidazol-1-ylmethyl)benzene, HNAA = α-naphthylacetic acid, phen = 1,10-phenanthroline) have been successfully synthesized under hydrothermal conditions. Their structures have been determined by elemental analyses, IR spectroscopy, TG and single-crystal X-ray diffraction analysis. The intermolecular hydrogen bonding or π-π stacking interactions extend the complexes into a 3D supramolecular structure. Moreover, the luminescent properties of complex 2 have been investigated in the solid state.
分类： 化学 >> 物理化学 提交时间： 2017-11-05 合作期刊: 《结构化学》
摘要：A new complex [Cd2(L)2(Cl)2(H2O)]n (1) was synthesized by reacting CdCl2·2.5H2O with 4-(1,2,4-triazol-4-yl)phenylacetic acid (HL) ligand. The structure of the complex was characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis and PXRD. Complex 1 crystallizes in triclinic, space group P21/c with a = 11.4303(8), b = 14.1792(10), c = 14.6857(10) Å, β = 96.3780(10)º, V = 2365.4(3) Å3, Z = 4, C20H16Cl2N6O5Cd2, Mr = 716.09, Dc = 2.011 g/cm3, μ = 2.069-1, S = 1.051, F(000) = 1392, the final R = 0.0458 and wR = 0.0949 for 5402 observed reflections (I > 2σ(I)). Complex 1 is a two-dimensional (2D) layer structure and non-covalent bonding interactions such as C–H···π and π···π extend the 2D to form a three-dimensional supramolecular polymer.
分类： 化学 >> 物理化学 提交时间： 2017-11-05 合作期刊: 《结构化学》
摘要：Using a rigid azo ligand 4-[(8-hydroxy-5-quinolinyl)azo]-benzoic acid (H2L), a new supramolecular compound [Zn(L)(H2O)2]n (1) has been solvothermally synthesized and structurally characterized by X-ray single-crystal diffraction, infrared spectrum, elemental analysis, power X-ray diffraction and thermal analysis. Compound 1 crystallizes in monoclinic, space group C2/c with a = 30.372(8), b = 11.415(3), c = 9.248(3) Å, β = 106.94(3)º, V = 3067.20(15) Å3, C16H13N3O5Zn, Mr = 392.66, Z = 8, Dc = 1.701 Mg/m3; F(000) = 1600, μ = 1.636 mm−1, reflections collected: 7290, reflections unique: 2735, Rint = 0.0282, R = 0.0351, wR (all data) = 0.0919, GOOF on F2 = 1.036. Compound 1 exhibits a one-dimensional (1D) zig-zag chain structure connected into a three-dimensional (3D) supramolecular network through hydrogen bonding interactions. Fluorescent property and electrochemical property were detected on compound 1.
分类： 化学 >> 物理化学 提交时间： 2017-11-05 合作期刊: 《结构化学》
摘要：Er3+/Yb3+ co-doped Li3Ba2Gd3(MoO4)8 phosphors were synthesized by conventional solid state reaction method, and their structure and spectral properties were investigated. The diffuse reflectance spectra showed that the 4I15/2 → 4I11/2 transition of Er3+ and the 2F7/2 → 2F5/2 transition of Yb3+ ions were highly overlapped. Under the excitation of 980 nm, three up-conversion (UC) luminescence bands around 530, 555 and 660 nm were observed, corresponding to the 2H11/2 → 4I15/2, 4S3/2 → 4I15/2 and 4F9/2 → 4I15/2 transitions of Er3+ ions, respectively. The effects of the concentration and pumping power on the UC intensities of Li3Ba2Gd3(MoO4)8:Er3+/Yb3+ phosphors were investigated, and the possible UC mechanism was proposed based on the results.
分类： 化学 >> 物理化学 提交时间： 2017-11-05 合作期刊: 《结构化学》
WANG Dao-Hua
LIN Xiao-Yan
WANG Yu-Kang
ZHANG Wen-Ting
SONG Kai-Yue
LIN Heng
LI Hao-Hong
CHEN Zhi-Rong
摘要：A new iodiplumbate/organic hybrid constructed from asymmetric viologen and polyiodides, (PBPY-H2)2[PbI4(I3)2] (1, PBPY = N-(propionate)-4,4΄-bipyridinium), has been synthesized via solvothermal reaction and structurally determined by X-ray diffraction method. Compound 1 crystallizes in monoclinic system, space group P21/c with Mr = 1936.72, a = 11.622(2), b = 14.839(3), c = 13.372(2) Å, β = 109.447(3)°, V = 2174.6(7) Å3, Z = 2, Dc = 2.958 g/cm3, F(000) = 1712, μ(MoKα) = 11.011 mm–1, the final R = 0.0389 and wR = 0.0854 for 3866 observed reflections with I > 2σ(I). [PbI4(I3)2]4- mononuclear cluster of 1 features a seldom example of coordinated I3- donors for the lead center. Intermolecular hydrogen bonds between [PbI4(I3)2]4- clusters and (PBPY-H)24+ dimmers contribute to the formation of a 2-D layer. Its absorption spectrum was investigated, and lower energy band gap of 1.42 eV was explained by DFT calculation. Interestingly, 1 exhibits photocatalytic activity for the degradation of rhodamine B.
分类： 化学 >> 物理化学 提交时间： 2017-11-05 合作期刊: 《结构化学》
摘要：Intermolecular interactions between PH2Cl and Ar–R (R = H, OH, NH2, CH3, Br, Cl, F, CN, NO2) were calculated by using MP2/aug-cc-pVDZ quantum chemical method. It has been shown from our calculations that the aromatic rings with electron-withdrawing groups represent much weaker binding affinities than those with electron-donating groups. The charge-transfer interaction between PH2Cl and Ar–R plays an important role in the formation of pnicogen bond complexes, as revealed by NBO analysis. Nevertheless, AIM analysis shows that the nature of the interactions between PH2Cl and Ar–R is electrostatic, and the interaction energies of the complexes are correlated positively with the electron densities in the bond critical points (BCPs). RDG/ELF graphical analyses were performed to visualize the positions and strengths of the pnicogen bonding, as well as the spatial change of the electron localization upon the formation of complexes. The π-type halogen bond was also calculated, and it has been revealed that the π-type pnicogen bond systems are more stable than the halogen bond ones.
分类： 化学 >> 物理化学 提交时间： 2017-11-05 合作期刊: 《结构化学》
摘要：Two new inorganic-organic hybrid vanadogermanates H[Cd(en)(phen)(H2O)][Cd(en)(phen)]{[Cd(phen)]2[Ge8V12O41(OH)7]}�H2O (1) and [Cd(dien)2][Cd(dien)]2{[Cd(phen)]2Ge8V12O42(H2O)(OH)6}�.5H2O (2) (en = ethylenediamine, dien = diethylenetriamine, phen = 1,10-phenanthroline) have been synthesized by hydrothermal method. Their structures were measured by single-crystal X-ray diffractions, thermogravimetric analysis, powder X-ray diffractions and infrared spectra. Structural analysis reveals that compound 1 is an infrequent dimeric structure based on di-Cd-substituted Ge-V-O cluster and transition-metal complex bridges, while compound 2 is an infinite 1-D chain constructed from di-Cd-substituted Ge-V-O clusters and dinuclear bridging complexes. Magnetic measurement indicated that both 1 and 2 exhibit antiferromagnetic behaviors.
分类： 化学 >> 物理化学 提交时间： 2017-11-05 合作期刊: 《结构化学》
摘要：The title compound, ethyl (R)-2-(biphenyl-4-carbonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4- b]indole-1-carboxylate (C27H24N2O3) has been synthesized, and its structure was characterized by 1H-NMR, 13C-NMR, ESI-MS and single-crystal X-ray diffraction. It crystallizes in the orthorhombic system, space group Pbca with a = 16.9950(8), b = 9.5445(4), c = 28.3188(3) Å, V = 4593.6(3) Å3, Z = 8, T = 294.64(10) K, μ(MoKα) = 0.08 mm-1, Dc = 1.228 g/cm3, F(000) = 1792.0 and GOOF = 1.036. 11836 reflections were measured (7.04≤2θ≤52.04°), and 4506 were unique (Rint = 0.0393, Rsigma = 0.0546) and used in all calculations. The final R = 0.0576 (I > 2σ(I)) and wR = 0.1563 (all data). The preliminary biological tests show that the title compound has a good antitumor activity against Hela in vitro with the IC50 value of 4.71 μmol/L.
分类： 化学 >> 物理化学 提交时间： 2017-11-05 合作期刊: 《结构化学》
摘要：Orthorhombic AgInS2 nanoplate and nanoparticle were synthesized using pyridine and 1-dodecanethiol as the solvent. The obtained products were characterized by X-ray diffraction (XRD), field-emission scanning electron microscope (FESEM), field-emission transmission electron microscope (FETEM), and the possible growth mechanism of AgInS2 was also proposed by the exploration of reaction temperature and time. Meanwhile, the bandgap of AgInS2 was calculated by the UV-Vis diffuse reflectance spectrum, and the photocatalytic activity was also investigated. Those experimental results indicate that the reaction temperature, reaction time and solvent have an influence on phase and morphology of AgInS2, and both AgInS2 nanoplate and nanoparticle have some ability on photocatalytic degradation of organic dyes under UV-Vis light irradiation.
分类： 化学 >> 物理化学 提交时间： 2017-11-05 合作期刊: 《结构化学》
摘要：Two coordination polymers (CPs), {[Ag(ADA)0.5(DPE)]·H2O}n (1) and {[Ag(ADA)0.5(Bipy)0.5]·H2O}n (2), (H2ADA = 3,3-azodibenzoic acid, DPE = 1,2-di(4-pyridyl)- ethylene, Bipy = 4,4΄-bipyridine), have been synthesized via solvothermal reactions of Ag+ with ADA2- and/or DPE, Bipy. CPs 1 and 2 were characterized by elemental analyses, IR spectra, thermal behaviors, and X-ray single-crystal diffraction. CPs 1 and 2 feature “Ag···Ag” subunits. CP 1 shows a 3D construction, in which the “Ag···Ag” subunits extend through ADA2- and DPE ligands using μ6-kO,O;kO;kO;kO,O;kO;kO and μ2-kO;kO coordination modes, respectively. It crystallizes in triclinic system, space group P, with a = 0.3808(18), b = 1.2476(6), c = 1.309(6) nm, α = 76.757(5), β = 84.649(5), γ = 86.809(5)º, V = 0.6024(5) nm3, Z = 2, Mr = 351.11, C13H11AgN2O3, Dc = 1.936 g/cm3, F(000) = 348, S = 1.064, R = 0.0323 and wR = 0.0689. CP 2 exhibits a 3D supramolecular structure, in which the “Ag···Ag” subunits are connected by ADA2- and DPE ligands with μ6-kO;kO;kO,O;kO;kO and μ2-kO;kO coordination modes, respectively. Ultimately, through hydrogen bond and π···π interaction, the “Ag···Ag” subunits stabilize the 3D supramolecular structure of 2. It crystallizes in monoclinic, space group C2/c, with a = 25.301(15), b = 13.197(8), c = 6.970(4) nm, β = 102.597(7)º, V = 2.271(2) nm3, Z = 8, C12H10AgN2O2.50, Mr = 330.09, Dc = 1.931 g/cm3, F(000) = 1304, S = 1.082, R = 0.1107 and wR = 0.2984. The fluorescence properties of CPs 1 and 2 have been also investigated.
分类： 化学 >> 物理化学 提交时间： 2017-11-05 合作期刊: 《结构化学》
摘要：A new metal-organic cadmium coordination polymer [Cd(pzdc)0.5(L)]n·nH2O (1, H2pzdc = pyrazine-2,3-dicarboxylic acid, HL = 3-(2-pyridyl)pyrazole) has been successfully synthesized under hydrothermal conditions. The structure has been determined by single-crystal X-ray diffraction analysis, elemental analyses, IR and fluorescence spectrum. Brown crystals crystallize in the orthorhombic system, space group Fdd2 with a = 11.2636(9), b = 38.296(3), c = 10.5795(8) Å, V = 4563.5(6) Å3, C11H9CdN4O3, Mr = 357.62, Dc = 2.082 g/cm3, μ(MoKα) = 1.924 mm-1, F(000) = 2800, Z = 16, the final R = 0.0169 and wR = 0.0443 for 2106 observed reflections (I > 2s(I)). It shows a two-dimensional network structure and extends into a three-dimensional supramolecular framework through π-π stacking interactions. Moreover, we analyzed Natural Bond Orbital (NBO) by using the PBE0/LANL2DZ method built in Gaussian 03 Program. The calculation results showed obvious covalent interaction between the coordinated atoms and Cd(II) ion.
分类： 化学 >> 物理化学 提交时间： 2017-11-05 合作期刊: 《结构化学》
摘要：A dinuclear dysprosium(III) compound, [Dy2(µ2-OH)2(QLC)4(1,10-phen)2]·4H2O (1) (QLC‒ = 2-quinolinecarboxylate and 1,10-phen = 1,10-phenanthroline), was synthesized and structurally and magnetically characterized. Compound 1 crystallizes in triclinic system, space group P with a = 10.9439(3), b = 11.2823(3), c = 12.2323(4) Å, α = 107.446(3), β = 91.700(3), γ = 91.511(2)°, V = 1439.25(8) Å3, Z = 1, C64H50N8O14Dy2, Mr = 1480.12, Dc = 1.708 g/cm3, μ = 2.653 mm−1 and F(000) = 734. The final R = 0.0366 and wR = 0.0736 for 5816 observed reflections with I > 2σ(I). Compound 1 contains the mononuclear [Dy(QLC)2(1,10-phen)] subunit formed from one 1,10-phen and two QLC‒ ligands chelating Dy(III) ion. Two mononuclear [Dy(QLC)2(1,10-phen)] subunits are bridged by a pair of µ2-OH groups to give a centrosymmetric dinuclear [Dy2(µ2-OH)2(QLC)4(1,10-phen)2] with each Dy(III) ion being eight-coordinated. Detailed susceptibility measurements revealed that compound 1 does not show slow magnetic relaxation under zero direct-current field but exhibits field-induced slow magnetic relaxation under 2 kOe applied field.
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