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1. chinaXiv:201711.02434 [pdf]

A Machine Learning Assisted, Label-free, Non-invasive Approach for Somatic Reprogramming inInduced Pluripotent Stem Cell Colony Formation Detection and Prediction

Fan, K (Fan, Ke); Zhang, S (Zhang, Sheng); Zhang, Y (Zhang, Ying); Lu, J (Lu, Jun); Holcombe, M (Holcombe, Mike); Zhang, X (Zhang, Xiao)
Subjects: Biology >> Ecology

During cellular reprogramming, the mesenchymal-to-epithelial transition is accompanied by changes in morphology, which occur prior to iPSC colony formation. The current approach for detecting morphological changes associated with reprogramming purely relies on human experiences, which involve intensive amounts of upfront training, human error with limited quality control and batch-to-batch variations. Here, we report a time-lapse-based bright-field imaging analysis system that allows us to implement a label-free, non-invasive approach to measure morphological dynamics. To automatically analyse and determine iPSC colony formation, a machine learning-based classification, segmentation, and statistical modelling system was developed to guide colony selection. The system can detect and monitor the earliest cellular texture changes after the induction of reprogramming in human somatic cells on day 7 from the 20-24 day process. Moreover, after determining the reprogramming process and iPSC colony formation quantitatively, a mathematical model was developed to statistically predict the best iPSC selection phase independent of any other resources. All the computational detection and prediction experiments were evaluated using avalidation dataset, and biological verification was performed. These algorithm-detected colonies show no significant differences (Pearson Coefficient) in terms of their biological features compared to the manually processed colonies using standard molecular approaches.

submitted time 2017-11-17 Hits321Downloads203 Comment 0

2. chinaXiv:201706.00739 [pdf]

Investigation on Cooling Effectiveness and Aerodynamic Loss of a Turbine Cascade with Film cooling

Liu, J. J., Lin, X. C., Zhang, X. D. and An, B. T.
Subjects: Dynamic and Electric Engineering >> Engineering Thermophysics

Effects of the uneven circumferential blade space on static characteristics and aerodynamic noise of a small axial flow fan are studied in this work. The blade angle modulation is adopted to design a series of unequally spaced fans, which have different maximum of modulation angular displacement. The steady flow is simulated by the calculations of Navier-Stokes equations coupled with RNG k-epsilon turbulence model, while the unsteady flow is computed with large eddy simulation. According to theoretical analysis, a fan with a maximum of modulation angular displacement of 6 is regarded as the optimal unequally spaced fan. The experiment of static characteristic is carried out in a standard wind tunnel and the aerodynamic noise of both fans is tested in a semi-anechoic room. Then, performances of the optimal unequally spaced fan are compared with those of the prototype fan. The results show that there is reasonable agreement between the simulation results and the experimental data. It is found that the discrete noise of the optimal unequally spaced fan is lower than that of the prototype fan at the near field monitoring point. This can be explained that the total pressure fluctuation of the optimal unequally spaced fan is much more regular than that of the prototype fan.

submitted time 2017-06-22 From cooperative journals:《热科学学报》 Hits1493Downloads303 Comment 0

3. chinaXiv:201705.00616 [pdf]

Investigation of the biofouling properties of several algae on different textured chemical modified silicone surfaces

Xu, JH [Xu, Jihai][ 1,2 ]; Zhao, WJ [Zhao, Wenjie][ 1 ]; Peng, SS [Peng, Shusen][ 1 ]; Zeng, ZX [Zeng, Zhixiang][ 1 ]; Zhang, X [Zhang, Xin][ 1 ]; Wu, XD [Wu, Xuedong][ 1 ]; Xue, QJ [Xue, Qunji][ 1 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

Engineered pillars, pits and grooves spaced 3, 6, 9 and 12 m apart were fabricated on siloxane modified acrylic resin films. The effect of feature size, geometry, and wettability on the settlement of different algae was evaluated. These films showed various antifouling performances to Ulothrix, Closterium and Navic- ula. For Navicula (length: 10–12 m), the feature size and geometry displayed a substantial correlation with the antifouling properties. The film with pillars spaced 3 m reduced Navicula settlement by 73% compared to the control surface. For Closterium (length: 45–55 m), their responses were governed by the same underlying thermodynamic principles as wettability, the largest reduction in Closterium, 81%, was obtained on the surface with grooves spaced 12 m apart. For Ulothrix (length: 5–8 mm), the surface also showed the best antifouling performance, the reduction ratio of the settlement on the surface with grooves spaced 12 m apart could even reach 92%. At last, physical fouling deterrent mechanisms for the films with various textures were analyzed in detail. The feature size and geometry display a substantial correlation with the antifouling properties when the size of fouling algae is close to the textures. With the increasing size for algae, antifouling performance was getting better on surface with pillars or grooves because the algae are bridged between two or more features other than stabilizing its entire mass on one single feature or able to settle between features.

submitted time 2017-05-02 Hits14844Downloads650 Comment 0

4. chinaXiv:201705.00438 [pdf]

A single-phase Ba9Lu2Si6O24:Eu2+, Ce3+, Mn2+ phosphor with tunable full-color emission for NUV-based white LED applications

Zhang, CH [Zhang, Changhua][ 1,2 ]; Liu, YF [Liu, Yongfu][ 2 ]; Zhang, JH [Zhang, Jiahua][ 3 ]; Zhang, X [Zhang, Xia][ 3 ]; Zhang, JX [Zhang, Jianxin][ 2,4 ]; Cheng, ZX [Cheng, Zhixuan][ 1 ]; Jiang, J [Jiang, Jun][ 2 ]; Jiang, HC [Jiang, Haochuan][ 2 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

We obtained a single phase BLS:Eu2+, Ce3+, Mn2+ phosphor by solid-state reactions. Eu2+, Ce3+, and Mn2+ gives rise to the blue, green, and red emission, respectively. The Mn2+ red emission can be effectively enhanced via energy transfers from both Eu2+ and Ce3+. Thus a tunable full color emission from 410 to 750 nm was realized in this single phosphor. The Eu2+ ! Mn2+ energy transfer mechanism was investigated by the fluorescence decay curves. This single phosphor exhibits an efficient excitation band covering from 390 to 410 nm, which matches well with the emission light of the efficient NUV chips. The optimized BLS:Eu2+, Ce3+, Mn2+ phosphor shows a high quantum efficient of $62% and a good color stability. When this single phosphor was combined with a 395 nm NUV-chip, an ideal white LED with a high color render index (CRI) of 85 and a correlated color temperature (CCT) of 6300 K was obtained. This demonstrates the promising application of the BLS:Eu2+, Ce3+, Mn2+ single phosphor for the NUV-based white LEDs.

submitted time 2017-05-02 Hits271Downloads184 Comment 0

5. chinaXiv:201612.00385 [pdf]

Dimension-six CP conserving operators of the third family quarks and their effects on collider observables

Whisnant,K; Yang,J; Young,B; Zhang,X
Subjects:

We list all possible dimension-six CP-conserving SUc(3)×SUL(2)×UY(1)SUc(3)×SUL(2)×UY(1)SU_c(3)\times SU_L(2) \times U_Y(1) invariant operators involving the third-family quarks which could be generated by new physics at a higher scale. Expressions for the

submitted time 2016-12-28 Hits844Downloads440 Comment 0

6. chinaXiv:201612.00383 [pdf]

R-parity violating supersymmetry effects and signals in single top production at the Tevatron

Datta,A; Yang,JM; Young,B; Zhang,X
Subjects:

We discuss single top quark production via u^i+\bar d^j \to t+\bar b at the Fermilab Tevatron in the minimal supersymmetric model with R-parity violation. We find that within the allowed range of coupling constants, the lepton-number violating couplings c

submitted time 2016-12-28 Hits764Downloads415 Comment 0

7. chinaXiv:201612.00381 [pdf]

Single top quark production as a probe of R-parity violating SUSY at p p and p anti-p colliders

Oakes,RJ; Whisnant,K; Yang,JM; Young,B; Zhang,X
Subjects:

We investigate the ability of single top quark production via qq'-> squark->tb and q \bar q'->slepton->t\bar b at the LHC and Tevatron to probe the strength of R-parity violating couplings in the minimal supersymmetric model. We found that given the exist

submitted time 2016-12-28 Hits912Downloads508 Comment 0

8. chinaXiv:201612.00380 [pdf]

Probing top quark decay into light stop in the supersymmetric standard model at the upgraded Tevatron

Hosch,M; Oakes,R; Whisnant,K; Yang,JM; Young,B; Zhang,X
Subjects:

We investigate the possibility of observing the exotic decay mode of the top quark into the lightest stop (t~1t~1\tilde t_1) and neutralino (χ~01χ~10\tilde\chi^0_1) in the minimal supersymmetric standard model with R-parity at the upgraded Tevatron. First

submitted time 2016-12-28 Hits846Downloads486 Comment 0

9. chinaXiv:201612.00379 [pdf]

Top quark at the upgraded Tevatron to probe new physics

Yang,J; Datta,A; Hosch,M; Li,C; Oakes,R; Whisnant,K; Young,B; Zhang,X
Subjects:

This talk is a brief review of the recent studies on probing new physics through single top quark processes and probing exotic top quark decays at the upgraded Tevatron.

submitted time 2016-12-28 Hits915Downloads478 Comment 0

10. chinaXiv:201612.00378 [pdf]

Effective CP violating operators of the tau lepton and some of their phenomenologies

Huang,T; Yang,J; Young,B; Zhang,X
Subjects:

The dimension-six CP-violating SU_L(2)\times U_Y(1) invariant operators involving the tau lepton are studied. The constraints from the available experimental data on tau dipole moments are derived. Under the current constraints, the induced CP-violating e

submitted time 2016-12-28 Hits844Downloads468 Comment 0

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