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1. chinaXiv:202006.00176 [pdf]

Automated Radiological Impression Generation for Plain Chest X-rays with End to End Deep Learning

Zhang, Shuai; Xin, Xiaoyan; Shen, Jingtao; Guo, Yachong; Wang, Yang; Yang, Xianfeng; Wang, Jun; Zhang, Jian; Zhang, Bing
Subjects: Computer Science >> Other Disciplines of Computer Science

The chest X-Ray (CXR) is the one of the most common clinical exam used to diagnose thoracic diseases and abnormalities. The volume of CXR scans generated daily in hospitals is huge. Therefore, an automated diagnosis system that is able to save the effort of doctors is of great value. At present, the applications of artificial intelligence in CXR diagnosis usually use pattern recognition to classify the scans. However, such methods rely on labeled databases. They are costly and usually have a high error rate. In this work, we built a database containing more than 12,000 CXR scans and radiological reports, and developed a model based on deep convolutional neural network and recurrent network with attention mechanism. The model learns features from the CXR scans and the associated raw radiological reports directly; no additional labeling required. The model provides automated recognition of given scans and generation of impression. The quality of the generated impression was evaluated with both the CIDEr scores and by radiologists as well. The CIDEr scores were found to be around 5.8 on average for the testing dataset. Further blind evaluation suggested a comparable performance against radiologists.

submitted time 2020-06-09 Hits3803Downloads173 Comment 0

2. chinaXiv:201705.00065 [pdf]

Structural effect on the resistive switching behavior of triphenylamine-based poly[azomethine]s

Zhang, WB [Zhang, Wenbin][ 1,2 ]; Wang, C [Wang, Cheng][ 3 ]; Liu, G [Liu, Gang][ 1 ]; Wang, J [Wang, Jun][ 2 ]; Chen, Y [Chen, Yu][ 3 ]; Li, RW [Li, Run-Wei][ 1 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

Linear and hyperbranched poly(azomethine)s (PAMs)-based on tri- phenylamine moieties are synthesized and used as the functioning layers in the Ta/PAM/Pt resistive switching memory devices. Com- parably, the hyperbranched PAM with isotropic architecture and semi-crystalline nature shows enhanced memory behaviors with more uniform distribution of the HRS and LRS resistances.

submitted time 2017-05-08 Hits1323Downloads491 Comment 0

3. chinaXiv:201705.00522 [pdf]

Thermally-stable resistive switching with a large ON/OFF ratio achieved in poly[triphenylamine]

Zhang, WB [Zhang, Wenbin][ 1,2,3 ]; Wang, C [Wang, Cheng][ 4 ]; Liu, G [Liu, Gang][ 1,3 ]; Zhu, XJ [Zhu, Xiaojian][ 1,3 ]; Chen, XX [Chen, Xinxin][ 1,3 ]; Pan, L [Pan, Liang][ 1,3 ]; Tan, HW [Tan, Hongwei][ 1,3 ]; Xue, WH [Xue, Wuhong][ 1,3 ]; Ji, ZH [Ji, Zhenghui][ 1,3 ]; Wang, J [Wang, Jun][ 2 ]; Chen, Y [Chen, Yu][ 4 ]; Li, RW [Li, Run-Wei][ 1,3 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

Thermally stable poly(triphenylamine) (PTPA) synthesized by an oxidative coupling reaction is used as the functional layer in memory devices, which exhibit non-volatile bistable resistive switching behavior with a large ON/OFF ratio over 5 108, a long retention time exceeding 8 103 s and a wide working temperature range of 30–390 K.

submitted time 2017-05-02 Hits2434Downloads330 Comment 0

4. chinaXiv:201705.00463 [pdf]

Interactions of Shear Bands in a Ductile Metallic Glass

Huo, LS [Huo, Li-shan][ 1,2 ]; Wang, JQ [Wang, Jun-qiang][ 1,2 ]; Huo, JT [Huo, Jun-tao][ 1,2 ]; Zhao, YY [Zhao, Yuan-yun][ 1,2 ]; Men, H [Men, He][ 1,2 ]; Chang, CT [Chang, Chun-tao][ 1,2 ]; Wang, XM [Wang, Xin-min][ 1,2 ]; Li, RW [Li, Run-wei][ 1,2 ]

Shear bands play a key role in the plastic deformation of metallic glasses [MGs]. Even though there are extensive studies on the initiation and propagation of shear bands, the interactions among them have not been systematically studied yet. The interacti

submitted time 2017-05-02 Hits534Downloads241 Comment 0

5. chinaXiv:201605.01410 [pdf]

The Roles of p21(Waf1/CIP1) and Hus1 in Generation and Transmission of Damage Signals Stimulated by Low-Dose Alpha-Particle Irradiation

Zhao, Ye; Wang, Jun; Chen, Shaopeng; Yuan, Hang; Xu, An; Wu, Lijun; Ma, Xiaoyan; Hang, Haiying; Ma, Xiaoyan; Hang, Haiying; Wang, Jun; Chen, Shaopeng; Yuan, Hang; Xu, An; Wu, Lijun; Wu, Lijun
Subjects: Biology >> Biophysics >> Biology

Previously reported studies have demonstrated the involvement of p21(Waf1/CIP1) in radiation-induced bystander effects (RIBE). Mouse embryonic fibroblasts (MEFs) lacking Hus1 fail to proliferate in vitro, but inactivation of p21 allows for the continued growth of Hus1-deficient cells, indicating the close connection between p21 and Hus1 cells. In this study, wildtype MEFs, Hus1(+/+)p21(-/-) MEFs and p21(-/-)Hus1(-/-) MEFs were used in a series of radiation-induced bystander effect experiments, the roles of p21 and Hus1 in the induction and transmission of radiation-induced damage signals were investigated. Our results showed that after 5 cGy alpha particle irradiation, wild-type MEFs induced significant increases in gamma-H2AX foci and micronuclei formation in bystander cells, whereas the bystander effects were not detectable in p21(-/-)Hus1(+/+) MEFs and were restored again in p21(-/-)Hus1(-/-) MEFs. Media transfer experiments showed that p21(-/-)Hus1(+/+) MEFs were deficient in the production bystander signals, but could respond to bystander signals. We further investigated the mitogen-activated protein kinases (MAPKs) that might be involved in the bystander effects. It was found that although knocking out p21 did not affect the expression of connexin43 and its phosphorylation, it did result in inactivation of some MAPK signal pathway kinases, including JNK1/2, ERK1/2 and p38, as well as a decrease in reactive oxygen species (ROS) levels in irradiated cells. However, the activation of MAPK kinases and the ROS levels in irradiated cells were restored in the cell line by knocking out Hus1. These results suggest that p21(Waf1/CIP1) and Hus1 play crucial roles in the generation and transmission of bystander damage signals after low-dose a particle irradiation. (C) 2015 by Radiation Research

submitted time 2016-05-12 Hits1262Downloads744 Comment 0

6. chinaXiv:201605.01292 [pdf]

Comparison of Hydrazide Chemistry and Lectin Affinity Based Enrichment Methods for N-glycoproteomics

Xue Peng; Zhou Yue; Ding Xiang; Wang Jun; Xie Zhen-Sheng; Yang Fu-Quan; Xue Peng; Zhou Yue; Wang Jun; Zhou Yue
Subjects: Biology >> Biophysics >> Biochemistry & Molecular Biology

Glycosylation is one of the most common and important post-translational modifications of proteins. Identification of large-scale N-linked glycoprotein is a very important aspect in glycoproteomics research. The N-glycopeptide enrichment is a key step in high-throughput identification of N-glycosylation site. Lectin enrichment and hydrazide chemistry are the two widely used N-glycopeptides enrichment methods. Each method can only enrich certain types of glycopeptides. It has been reported that the two methods are highly complementary, but few studies compared overlaps of glycosties from the two methods. In this paper, using HepG2 cells, we systematically compared the performance of hydrazide chemistry and lectins enrichment methods. The results showed that although the hydrazide method with glycopeptides enrichment efficiency of 76.7%, far higher than the 54.6% lectin enrichment method, 825 glycoprotein and 1 879 N-glycosylation sites identified with the lectin method was significantly more than 522 glycoprotein and 1 014 glycosylation sites enriched by the hydrazide method. Moreover, the two methods did not show significant complementary, together, only 853 glycoproteins and 1 959 N-glycosylation sites were identified. The overlapping results of identified N-glycosylation sites and N-glycoproteins from the two methods show that lectins enrichment method was better than hydrazide chemistry method.

submitted time 2016-05-11 Hits789Downloads483 Comment 0

7. chinaXiv:201605.00713 [pdf]

Calstabin 2: An important regulator for learning and memory in mice

Yuan, Qi; Chi, Shaopeng; Yang, Zhiguang; Wang, Jun; Ji, Guangju; Yuan, Qi; Deng, Ke-Yu; Xin, Hong-Bo; Sun, Le; Wang, Xiaoqun; Chi, Shaopeng;
Subjects: Biology >> Biophysics

Calstabin2, also named FK506 binding protein 12.6 (FKBP12.6), is a subunit of ryanodine receptor subtype 2 (RyR2) macromolecular complex, which is an intracellular calcium channel and abundant in the brain. Previous studies identified a role of leaky neuronal RyR2 in posttraumatic stress disorder (PTSD). However, the functional role of Calstabin2 in the cognitive function remains unclear. Herein, we used a mouse model of genetic deletion of Calstabin2 to investigate the function of Calstabin2 in cognitive dysfunction. We found that Calstabin2 knockout (KO) mice showed significantly reduced performance in Morris Water Maze (MWM), long-term memory (LTM) contextual fear testing, and rotarod test when compared to wild type (WT) littermates. Indeed, genetic deletion of Calstabin2 reduced long-term potentiation (LTP) at the hippocampal CA3-CA1 connection, increased membrane excitability, and induced RyR2 leak. Finally, we demonstrated that the increase in cytoplasmic calcium activated Ca2+ dependent potassium currents and led to neuronal apoptosis in KO hippocampal neurons. Thus, these results suggest that neuronal RyR2 Ca2+ leak due to Calstabin2 deletion contributes to learning deficiency and memory impairment.

submitted time 2016-05-05 Hits763Downloads415 Comment 0

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