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1. chinaXiv:201711.02418 [pdf]

PSCA and MUC1 in Non-small-cell Lung Cancer as Targets of Chimeric Antigen Receptor T cells

Wei, XR [ 1,2,3 ]; Lai, YX [ 1,2,3 ]; Li, J [ 4 ]; Qin, L [ 1,2,3 ]; Xu, YD [ 1,2,3 ]; Zhao, RC [ 1,2,3 ]; Li, BH [ 1,2,3 ]; Lin, SM [ 1,2,3 ]; Wang, SN [ 1,2,3 ]; Wu, QT [ 1,2,3 ]; Liang, QB [ 5 ]; Peng, MY [ 6 ]; Yu, FL [ 6 ]; Li, YQ [ 7 ]; Zhang, XC [ 8 ]; Wu, YL [ 8 ]; Liu, PT [ 9 ]; Pei, DQ [ 1,2 ]; Yao, Y [ 1,2,3 ]; Li, P [ 1,2,3 ]
Subjects: Biology >> Ecology

In?recent years, immunotherapies, such?as?those involving?chimeric?antigen?receptor?(CAR)?T?cells, have become increasingly promising approaches to?non-small-cell?lung?cancer?(NSCLC) treatment.?In?this study, we explored the antitumor potential?of?prostate stem cell?antigen?(PSCA)-redirected CAR?T?and mucin 1 (MUC1)-redirected CAR?T?cells?in?tumor models?of?NSCLC. First, we generated patient-derived xenograft (PDX) mouse models?of?human NSCLC that maintained the antigenic profiles?of?primary tumors. Next, we demonstrated the expression?of?PSCA?and?MUC1?in?NSCLC, followed by the generation and confirmation?of?the specificity and efficacy?of?PSCA-and?MUC1-targeting CAR?T?cells?against NSCLC cell lines?in?vitro. Finally, we demonstrated that?PSCA-targeting CAR?T?cellscould efficiently suppress NSCLC tumor growth?in?PDX mice and synergistically eliminate?PSCA(+)MUC1(+) tumors when combined with?MUC1-targeting CAR?Tcells. Taken together, our studies demonstrate that?PSCA?and?MUC1?are both promising CAR?T?cell?targets?in?NSCLC and that the combinatorial targeting?ofthese antigens could further enhance the antitumor efficacy?of?CAR?T?cells.

submitted time 2017-11-17 Hits737Downloads422 Comment 0

2. chinaXiv:201705.00615 [pdf]

Interface Modification of ZnO-Based Inverted PTB7:PC71BM Organic Solar Cells by Cesium Stearate and Simultaneous Enhancement of Device Parameters

Wang, GJ [Wang, Guojie][ 1,2 ]; Jiu, TG [Jiu, Tonggang][ 1 ]; Tang, G [Tang, Gang][ 1 ]; Li, J [Li, Jun][ 1 ]; Li, PD [Li, Pandeng][ 1 ]; Song, XJ [Song, Xiaojin][ 2 ]; Lu, FS [Lu, Fushen][ 2 ]; Fang, JF [Fang, Junfeng][ 1 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

We used cesium stearate (CsSt) to modify the interface of the electron- extracting contact in inverted organic solar cells. Surface microstructure, optical properties, and electrical characterization as well as exciton generation rate and dissociation probability were investigated to understand the impact of CsSt on the interface contact. The results indicated that by incorporation of CsSt, the surface morphology and energy level as well as conductivity of a zinc oxide (ZnO) film were improved. On the basis of the above properties, highly efficient inverted organic solar cells have been demonstrated by using a ZnO nanoparticle film and CsSt stacked bilayer structure as the cathode interfacial layer. The insertion of a CsSt layer between the ZnO film and active layer improved the electron extraction efficiency, and a high power conversion efficiency (PCE) of 8.69% was achieved. The PCE was improved by 20% as compared to the reference device using a ZnO-only electron extraction layer.

submitted time 2017-05-02 Hits14888Downloads702 Comment 0

3. chinaXiv:201705.00577 [pdf]

Tunable crystallographic grain orientation and Raman fingerprints of polycrystalline SnO thin films

Liu, Q [Liu, Quan][ 1,2 ]; Liang, LY [Liang, Lingyan][ 1 ]; Cao, HT [Cao, Hongtao][ 1 ]; Luo, H [Luo, Hao][ 1 ]; Zhang, HL [Zhang, Hongliang][ 1 ]; Li, J [Li, Jun][ 1 ]; Li, XX [Li, Xiuxia][ 1 ]; Deng, FL [Deng, Fuling][ 1 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

In this study, (001) and (101)-orientated polycrystalline SnO films were respectively fabricated. The preferred orientation conversion was observed by modifying the stoichiometry of the SnO films. It was revealed that the O-rich and Sn-rich SnO films favor (001) and (101) grain orientations, respectively. Moreover, based on the Raman selection rule and our experimental results, the 110 cm 1 Raman peak is assigned to the low- frequency Eg mode of SnO. The Raman intensity ratio between the 110 cm 1 and 210 cm 1 peak of SnO increases with the relative texture coefficient of the (101) grain orientation but decreases with that of the (001) one, demonstrating that the Raman characteristic information could be used as fingerprint recognition to mutually predict the crystallographic texture of SnO films.

submitted time 2017-05-02 Hits588Downloads292 Comment 0

4. chinaXiv:201705.00544 [pdf]

High-Performance Inverted Solar Cells Based on Blend Films of ZnO Naoparticles and TiO2 Nanorods as a Cathode Buffer Layer

Li, PD [Li, Pandeng][ 1,2 ]; Sun, CM [Sun, Chunming][ 1 ]; Jiu, TG [Jiu, Tonggang][ 1 ]; Wang, GJ [Wang, Guojie][ 1 ]; Li, J [Li, Jun][ 1 ]; Li, XF [Li, Xiaofang][ 2 ]; Fangt, JF [Fangt, Junfeng][ 1 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

We reported the favorable cathode buffer layer based on a blend of ZnO nanoparticles (NPs) and TiO2 nanorods (NRs) applied to inverted solar cells. In addition to the high optical transmittance, the resultant blend film gave a relatively dense film with lower roughness than that of the respective single-component film. This improved the interface contact between the buffer layer and photoactive layer and therefore reduced the contact resistance and leakage current. Moreover, the combination of NRs and NPs increased the efficiency of electron transport and collection by providing both a direct path for electron transport from TiO2 NRs and a large contact area between ZnO NPs and the active layer. Consequently, both the short-circuit current density (Jsc) and fill factor (FF) in the device were improved, leading to an improvement of the device performance. The best power conversion efficiency (PCE) based on the blend film as the buffer layer reached 8.82%, which was preferable to those of a single ZnO NP film (7.76%) and a TiO2 NR-based device (7.66%). KEYWORDS: ZnO nanoparticles, TiO2 nanorods, blend film, cathode buffer layer, inverted solar cells

submitted time 2017-05-02 Hits577Downloads346 Comment 0

5. chinaXiv:201705.00534 [pdf]

Tailoring the resonance wavelength and loss of highly Ga doped ZnO plasmonic materials by varied doping content and substrate temperature

Zhu, CT [Zhu, Chaoting][ 1 ]; Li, J [Li, Jia][ 1 ]; Yang, Y [Yang, Ye][ 1 ]; Lan, PJ [Lan, Pinjun][ 1 ]; Huang, JH [Huang, Jinhua][ 1 ]; Lu, YH [Lu, Yuehui][ 1 ]; Tan, RQ [Tan, Ruiqin][ 2 ]; Dai, N [Dai, Ning][ 3 ]; Song, WJ [Song, Weijie][ 1,4 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

In this paper, Ga-doped ZnO (GZO) thin films are deposited on glass substrates by radio frequency magnetron sputtering for low loss plasmonic applications. The effects of Ga2O3 content in the target and substrate temperature on the electrical, structural and optical properties of GZO films are investigated. Film with the highest carrier concen- tration of 7.0 × 1020 cm? 3 was obtained at a Ga2O3 content of 5 wt% in the target under room temperature deposi- tion. With increasing deposition temperature, the lowest electrical resistivity of 3.8 × 10? 4 Ω cm was acquired at a deposition temperature of 200 °C. The values of plasmonic resonances wavelength could be changed from 1.35 to 2.39 μm by adjusting the carrier concentration. Material absorption losses in these GZO films are 10 times lower than that of conventional Ag films at telecommunication wavelengths. These results make GZO a promising low-loss plasmonic material operating at telecommunication wavelengths.

submitted time 2017-05-02 Hits2370Downloads429 Comment 0

6. chinaXiv:201705.00531 [pdf]

A highly thermostable and transparent lateral heat spreader based on silver nanowire/polyimide composite

Li, JP [Li, Junpeng][ 1 ]; Qi, SH [Qi, Shuhua][ 1 ]; Li, J [Li, Juan][ 2 ]; Zhang, MY [Zhang, Mengyu][ 1 ]; Wang, ZF [Wang, Zhaofu][ 1 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

Heat accumulation is a severe problem for high-power light-emitting diodes (LEDs). Here, we introduce a thermostable and transparent lateral heat spreader as an additional heat-escaping channel of an LED chip to improve the thermal management of LED devices. The lateral heat spreader was prepared based on a silver nanowire (AgNW)/polyimide composite comprising a thin polyacrylate layer soldering a conductive AgNW network to confine the nanowires to the surface of a polyimide film and to obtain low contact resistance between the nanowires. The AgNW/polyimide composite film has a figure-of-merit sheet resistance of 7 ohm sq 1 with 76% transmittance at 550 nm. After heating at 200 C for 168 h, the sheet resistance increases to 16 ohm sq 1. The thermal conductivity and thermal diffusivity are 130.2 W m 1 K 1 and 60.5 mm2 s 1, respectively, which are comparable to those of a commercial copper foil. A demonstration shows the core temperature in a thermal diffusion apparatus can be lowered by 9 C. The experimental data combined with computational simulation indicate the Joule heating could be drawn away efficiently along the lateral heat spreader.

submitted time 2017-05-02 Hits774Downloads309 Comment 0

7. chinaXiv:201705.00498 [pdf]

Synaptic devices based on purely electronic memristors

Pan, RB [Pan, Ruobing][ 1,2 ]; Li, J [Li, Jun][ 1 ]; Zhuge, F [Zhuge, Fei][ 1 ]; Zhu, LQ [Zhu, Liqiang][ 1 ]; Liang, LY [Liang, Lingyan][ 1 ]; Zhang, HL [Zhang, Hongliang][ 1 ]; Gao, JH [Gao, Junhua][ 1 ]; Cao, HT [Cao, Hongtao][ 1 ]; Fu, B [Fu, Bing][ 1 ]; Li, K [Li, Kang][ 1 ]

Memristive devices have been widely employed to emulate biological synaptic behavior. In these cases, the memristive switching generally originates from electrical field induced ion migration or Joule heating induced phase change. In this letter, the Ti/Z

submitted time 2017-05-02 Hits655Downloads325 Comment 0

8. chinaXiv:201705.00496 [pdf]

Determination of the basic optical parameters of ZnSnN2

Deng, FL [Deng, Fuling][ 1,2 ]; Cao, HT [Cao, Hongtao][ 2 ]; Liang, LY [Liang, Lingyan][ 2 ]; Li, J [Li, Jun][ 2 ]; Gao, JH [Gao, Junhua][ 2 ]; Zhang, HL [Zhang, Hongliang][ 2 ]; Qin, RF [Qin, Ruifeng][ 2 ]; Liu, CC [Liu, Caichi][ 1 ]

Polycrystalline ZnSnN2 thin films were successfully prepared by DC magnetron sputtering at room temperature. Both the as-deposited and annealed films showed n-type conduction, with electron concentration varying between 1.6 x 10[18] and 2.3 x 10[17] cm[-3

submitted time 2017-05-02 Hits517Downloads306 Comment 0

9. chinaXiv:201705.00489 [pdf]

Realization of a flexible and mechanically robust Ag mesh transparent electrode and its application in a PDLC device

Qi, LF [Qi, Liangfei][ 1,2 ]; Li, J [Li, Jia][ 1 ]; Zhu, CT [Zhu, Chaoting][ 1 ]; Yang, Y [Yang, Ye][ 1 ]; Zhao, SJ [Zhao, Shijin][ 2 ]; Song, WJ [Song, Weijie][ 1 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

In this paper, flexible Ag electrodes with a hexagonal micromesh structure were fabricated on PET substrate using a photolithography technique. The effect of film thickness on optical and electrical properties of Ag electrodes was investigated systematically. Furthermore, these flexible transparent Ag mesh electrodes were firstly applied to a polymer dispersed liquid crystal (PDLC) device and its performance was evaluated. All of the Ag electrodes exhibited a high average transmittance of about 80.2–85.0% in the visible range (400–800 nm), and the minimum sheet resistance value reached 8.2 U sq 1. The prepared Ag mesh also showed an excellent performance of adhesion and bending, demonstrating its superior durability. The PDLC device based on Ag mesh electrodes showed comparable performance with that using ITO electrodes, indicating that the Ag mesh film can be a good substitution for ITO electrodes in PDLC devices and may find practical application in large area flexible devices.

submitted time 2017-05-02 Hits592Downloads364 Comment 0

10. chinaXiv:201705.00451 [pdf]

Optimization Design for SRM based on the Regulation Model of Ampere Density and Coil Space Factor

Zhang, XP [Zhang, Xianpeng][ 1 ]; Lan, PJ [Lan, Pinjun][ 1 ]; Lu, YH [Lu, Yuehui][ 1 ]; Li, J [Li, Jia][ 1 ]; Xu, H [Xu, Hua][ 2 ]; Zhang, J [Zhang, Jing][ 1 ]; Lee, Y [Lee, YoungPak][ 3,4 ]; Rhee, JY [Rhee, Joo Yull][ 5 ]; Choy, KL [Choy, Kwang-Leong][ 6 ]; Song, WJ [Song, Weijie][ 1 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

In the preliminary design process of switched reluctance machine (SRM), adjusting the number of wingding turns or cross-sectional area of conductor to optimize windings design has dramatic effects on the performances like torque density, efficiency and thermal dissipation and so on. However, the difficulty exists on how to guarantee these performances while optimizing winding design. This paper proposes an analytical optimization design method based on an regulation model of ampere density and coil space factor, which can directly determine the optimal number of winding turns, the cross- sectional area of conductor, the ampere density and the coil space factor. And a MATLAB pre-design program has been developed to provide two design schemes respectively with and without the optimization model. The comparison analysis has been further carried out with finite element analysis (FEA). The simulation results verify that the performances can be highly improved with the proposed optimization model.

submitted time 2017-05-02 Hits674Downloads392 Comment 0

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