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1. chinaXiv:201705.00095 [pdf]

Research progress on bio-based thermosetting resins

Ma, SQ [Ma, Songqi][ 1 ]; Li, TT [Li, Tingting][ 1,2 ]; Liu, XQ [Liu, Xiaoqing][ 1 ]; Zhu, J [Zhu, Jin][ 1 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

Compared with the rapid progress on bio-based thermoplastics, research on bio-based thermosetting resins should have attracted much more attention, considering that they will have a bright future. In this paper, the current research progress on bio-based thermosetting resins is reviewed. We pay special attention to the synthesis and investigation of properties of epoxies and unsaturated polyesters derived from renewable plant oil, cardanol, rosin acid, lignin, glycerol, gallic acid, furan, isosorbide, itaconic acid, etc. This mini review gives an overall perspective for bio-based thermosets. © 2015 Society of Chemical Industry

submitted time 2017-05-08 Hits797Downloads380 Comment 0

2. chinaXiv:201605.01413 [pdf]

Lysine Malonylation Is Elevated in Type 2 Diabetic Mouse Models and Enriched in Metabolic Associated Proteins

Du, Yipeng; Zhou, Bo; He, Xiaolong; Wei, Peng; Liu, Pingsheng; Wei, Taotao; Cai, Tanxi; Xue, Peng; Yang, Fuquan; Cai, Tanxi; Xue, Peng; Yang, Fuquan; Li, Tingting; Cai, Tanxi; Zhou, Bo; He, Xiaolong; Wei, Peng
Subjects: Biology >> Biophysics

Protein lysine malonylation, a newly identified protein post-translational modification (PTM), has been proved to be evolutionarily conserved and is present in both eukaryotic and prokaryotic cells. However, its potential roles associated with human diseases remain largely unknown. In the present study, we observed an elevated lysine malonylation in a screening of seven lysine acylations in liver tissues of db/db mice, which is a typical model of type 2 diabetes. We also detected an elevated lysine malonylation in ob/ob mice, which is another model of type 2 diabetes. We then performed affinity enrichment coupled with proteomic analysis on liver tissues of both wild-type (wt) and db/db mice and identified a total of 573 malonylated lysine sites from 268 proteins. There were more malonylated lysine sites and proteins in db/db than in wt mice. Five proteins with elevated malonylation were verified by immunoprecipitation coupled with Western blot analysis. Bioinformatic analysis of the proteomic results revealed the enrichment of malonylated proteins in metabolic pathways, especially those involved in glucose and fatty acid metabolism. In addition, the biological role of lysine malonylation was validated in an enzyme of the glycolysis pathway. Together, our findings support a potential role of protein lysine malonylation in type 2 diabetes with possible implications for its therapy in the future.

submitted time 2016-05-12 Hits583Downloads360 Comment 0

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