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1. chinaXiv:201711.02422 [pdf]

Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1

Li, L (Li, Li); Zhang, QJ (Zhang, Quanjun); Yang, HQ (Yang, Huaqiang); Zou, QJ (Zou, Qingjian); Lai, CD (Lai, Chengdan); Jiang, F (Jiang, Fei); Zhao, P (Zhao, Ping); Luo, ZW (Luo, Zhiwei); Yang, JY (Yang, Jiayin); Chen, Q (Chen, Qian); Wang, Y (Wang, Yan); Newsome, PN (Newsome, Philip N.); Frampton, J (Frampton, Jon); Maxwell, PH (Maxwell, Patrick H.); Li, WJ (Li, Wenjuan); Chen, SH (Chen, Shuhan); Wang, DY (Wang, Dongye); Siu, TS (Siu, Tak-Shing); Tam, S (Tam, Sidney); Tse, HF (Tse, Hung-Fat)
Subjects: Biology >> Ecology

From the (a)CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China, and Guangzhou Medical University, Guangzhou 511436, China, (b)CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China, (c)Laboratory of RNA, Chromatin, and Human Disease, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China, (d)Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China, (e)Hong Kong-Guangdong Stem Cell and Regenerative Medicine Research Centre, The University of Hong Kong and Guangzhou Institutes of Biomedicine and Health, Hong Kong SAR, China, (f)Department of Ophthalmology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China, (g)State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangdong Provincial Research Center for Liver Fibrosis, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital and (h)Biomedical Research Center, Southern Medical University, Guangzhou 510515, China, (i)Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, (j)National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit and Centre for Liver Research, and (k)Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom, (l)Cambridge Institute for Medical Research, Wellcome Trust/Medical Research Council (MRC) Building, Cambridge CB2 0XY, United Kingdom, mDepartment of Clinical Biochemistry Unit, Queen Mary Hospital, Hong Kong SAR, China, (n)Department of Medicine, University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, Guangdong, China, and (o)Laboratory of Metabolism and Cell Fate, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, Guangdong, China

submitted time 2017-11-17 Hits482Downloads269 Comment 0

2. chinaXiv:201711.02424 [pdf]

Discovery of potent dipeptidyl peptidase IV inhibitors through pharmacophore hybridization and hit-to-lead optimization

Zeng, SG (Zeng, Shaogao); Xie, H (Xie, Hui); Zeng, LL (Zeng, Li-li); Lu, X (Lu, Xin); Zhao, X (Zhao, Xin); Zhang, GC (Zhang, Gui-cheng); Tu, ZC (Tu, Zheng-chao); Xu, HJ (Xu, Hong-jiang); Yang, L (Yang, Ling); Zhang, XQ (Zhang, Xi-quan); Hu, WH (Hu, Wenhui)
Subjects: Biology >> Ecology

A novel dipeptidyl peptidase IV inhibitor hit (5, IC50 = 0.86 mu M) was structurally derived from our recently disclosed preclinical candidate 4 by replacing the cyanobenzyl with a butynyl based on pharmacophore hybridization. A hit-to-lead optimization effort was then initiated to improve its potency. Most N-substituted analogs exhibited good in vitro activity, and compound 180 (IC50 = 1.55 nM) was identified to be a potent dipeptidyl peptidase IV inhibitor with a significantly improved pharmacokinetic properties (bioavailablity: 41% vs 82.9%; T-1/2: 2 h vs 4.9 h). (C) 2013 Elsevier Ltd. All rights reserved.

submitted time 2017-11-17 Hits467Downloads271 Comment 0

3. chinaXiv:201711.00139 [pdf]

Precisely Composition Controlled Synthesis of Cu0.5Ni0.5 Alloy with Optimum Catalytic Activity

XU Xing-Liang; LI Li-Ping; ZHANG Dan; LUO Jia-Jun; LI Guang-She
Subjects: Chemistry >> Physical Chemistry

Alloys based on non-noble metals could be the next generation of high-performance catalysts for many chemical reactions. However, precisely composition controlled synthesis of non-noble alloys remains a significant challenge. In this work, we report a simple synthesis of Cu0.5Ni0.5 alloys without any component segregation. Its success relies on the use of Cu–Ni oxalate precursors, which are chelated in the proximity by oxalate ligands. One of the attractive features for the oxalate routes of catalyst preparation is that no classical support material is needed. The actual component ratios of the obtained Cu0.5Ni0.5 alloy are consistent with the initial ratio. Cu0.5Ni0.5 alloy shows a higher catalytic activity than pure Cu and Ni catalysts in the reduction of p-nitrophenol (4-NP) to p-aminophenol (4-AP) by sodium borohydride (NaBH4) in an aqueous solution, and the performance depends strongly on the strong interaction between Cu and Ni. The findings reported here are highly helpful to understand the relationship between the synergistic effects in alloys and their catalytic performance, and therefore could provide appropriate strategies to obtain desirable catalysts with improved activity in various catalytic applications.

submitted time 2017-11-05 From cooperative journals:《结构化学》 Hits608Downloads270 Comment 0

4. chinaXiv:201703.01047 [pdf]

Correlation Analysis of Transient Heat Transfer Characteristics for Air Pre- cooling Aggregate

Chaohong; ZENG Miao; LU Fei; TANG Dawei GUAN Wei; LI Li; FU Tingwu
Subjects: Dynamic and Electric Engineering >> Engineering Thermophysics

In dam works, air precooling of aggregate is a common and effective method to avoid temperature cracks in con- crete structure. In order to offer a reliable design theory for the air precooling process to avoid unreasonable energy consumption, the transient heat transfer characteristics of the aggregate are intensively analyzed. The combined structure of the aggregate and the interstitial space in the hopper is treated as a porous structure, and the space-average method is used to simulate the transient heat transfer process. Simulation results show that size of the hopper and the average air velocity in the cross section have great influence on the transient heat transfer process of the aggregate, while the porosity in the range of 0.4‒0.5 has little influence. Nomograms are abstracted from simulation results, and then correlations of the compared excess temperature are precisely fitted to predict the air precooling transient heat transfer process of the aggregate.

submitted time 2017-03-31 From cooperative journals:《热科学学报》 Hits1008Downloads317 Comment 0

5. chinaXiv:201612.00110 [pdf]

Phase structure of the Born-Infeld-anti-de Sitter black holes probed by non-local observables

Zeng, Xiao-Xiong; Liu, Xian-Ming; Li, Li-Fang
Subjects: Geosciences >> Space Physics

With the non-local observables such as two point correlation function and holographic entanglement entropy, we probe the phase structure of the Born-Infeld-anti-de Sitter black holes. For the case bQ > 0.5, where b is the Born-Infeld parameter and Q is the charge of the black hole, the phase structure is found to be similar to that of the Van der Waals phase transition, namely the black hole undergoes a first order phase transition and a second order phase transition before it reaches a stable phase. While for the case bQ < 0.5, a new phase branch emerges besides the Van der Waals phase transition. For the first order phase transition, the equal area law is checked, and for the second order phase transition, the critical exponent of the heat capacity is obtained. All these results are found to be the same as that observed in the entropy-temperature plane.

submitted time 2016-12-26 Hits524Downloads276 Comment 0

6. chinaXiv:201612.00088 [pdf]

A holographic study on vector condensate induced by a magnetic field

Cai, Rong-Gen; He, Song; Li, Li; Li, Li-Fang
Subjects: Geosciences >> Space Physics

We study a holographic model with vector condensate by coupling the anti-de Sitter gravity to an Abelian gauge field and a charged vector field in (3 + 1) dimensional spacetime. In this model there exists a non-minimal coupling of the vector field to the gauge field. We find that there is a critical temperature below which the charged vector condenses via a second order phase transition. The DC conductivity becomes infinite and the AC conductivity develops a gap in the condensed phase. We study the effect of a background magnetic field on the system. It is found that the background magnetic field can induce the condensate of the vector field even in the case without chemical potential/charge density. In the case with non-vanishing charge density, the transition temperature raises with the applied magnetic field, and the condensate of the charged vector operator forms a vortex lattice structure in the spatial directions perpendicular to the magnetic field.

submitted time 2016-12-22 Hits873Downloads437 Comment 0

7. chinaXiv:201612.00087 [pdf]

Vector condensate and AdS soliton instability induced by a magnetic field

Cai, Rong-Gen; Li, Li; Li, Li-Fang; Wu, You
Subjects: Geosciences >> Space Physics

We continue to study the holographic p-wave superconductor model in the Einstein-Maxwell-complex vector field theory with a non-minimal coupling between the complex vector field and the Maxwell field. In this paper we work in the AdS soliton background which describes a conformal field theory in the confined phase and focus on the probe approximation. We find that an applied magnetic field can lead to the condensate of the vector field and the AdS soliton instability. As a result, a vortex lattice structure forms in the spatial directions perpendicular to the applied magnetic field. As a comparison, we also discuss the vector condensate in the Einstein-SU(2) Yang-Mills theory and find that in the setup of the present paper, the Einstein-Maxwell-complex vector field model is a generalization of the SU(2) model in the sense that the vector field has a general mass and gyromagnetic ratio.

submitted time 2016-12-22 Hits761Downloads437 Comment 0

8. chinaXiv:201612.00085 [pdf]

Competition between s-wave order and d-wave order in holographic superconductors

Li, Li-Fang; Cai, Rong-Gen; Li, Li; Wang, Yong-Qiang
Subjects: Geosciences >> Space Physics

We study competition between s-wave order and d-wave order through two holographic superconductor models. We find that once the coexisting phase appears, it is always thermodynamically favored, and that the coexistence phase is narrow and one condensate tends to kill the other. The phase diagram is constructed for each model in terms of temperature and the ratio of charges of two orders. We further compare the behaviors of some thermodynamic quantities, and discuss the different aspects and identical ones between two models.

submitted time 2016-12-22 Hits805Downloads440 Comment 0

9. chinaXiv:201612.00084 [pdf]

Entanglement entropy in a holographic p-wave superconductor model

Li, Li-Fang; Cai, Rong-Gen; Li, Li; Shen, Chao
Subjects: Geosciences >> Space Physics

In a recent paper, arXiv:1309.4877, a holographic p-wave model has been proposed in an Einstein Maxwell-complex vector field theory with a negative cosmological constant. The model exhibits rich phase structure depending on the mass and the charge of the vector field. We investigate the behavior of the entanglement entropy of dual field theory in this model. When the above two model parameters change, we observe the second order, first order and zeroth order phase transitions from the behavior of the entanglement entropy at some intermediate temperatures. These imply that the entanglement entropy can indicate not only the occurrence of the phase transition, but also the order of the phase transition. The entanglement entropy is indeed a good probe to phase transition. Furthermore, the "retrograde condensation" which is a sub-dominated phase is also reflected on the entanglement entropy. (C) 2015 The Authors. Published by Elsevier B.V.

submitted time 2016-12-22 Hits731Downloads417 Comment 0

10. chinaXiv:201605.01171 [pdf]

Vector condensate and AdS soliton instability induced by a magnetic field

Cai, Rong-Gen; Li, Li; Li, Li-Fang; Wu, You
Subjects: Physics >> The Physics of Elementary Particles and Fields

We continue to study the holographic p-wave superconductor model in the Einstein-Maxwell-complex vector field theory with a non-minimal coupling between the complex vector field and the Maxwell field. In this paper we work in the AdS soliton background which describes a conformal field theory in the confined phase and focus on the probe approximation. We find that an applied magnetic field can lead to the condensate of the vector field and the AdS soliton instability. As a result, a vortex lattice structure forms in the spatial directions perpendicular to the applied magnetic field. As a comparison, we also discuss the vector condensate in the Einstein-SU(2) Yang-Mills theory and find that in the setup of the present paper, the Einstein-Maxwell-complex vector field model is a generalization of the SU(2) model in the sense that the vector field has a general mass and gyromagnetic ratio.

submitted time 2016-05-09 Hits712Downloads365 Comment 0

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