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1. chinaXiv:201704.00093 [pdf]

Janus Polymer/Carbon Nanotube Hybrid Membranes for Oil/Water Separation

Gu, JC; Xiao, P; Chen, J; Zhang, JW; Huang, YJ; Chen, T
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

A robust and simple method is provided to fabricate Janus polymer/carbon nanotube (CNT) hybrid membranes for oil/water separation. Starting from CNT membranes formed by dispensing, hydrophobic poly(styrene) (PS) and hydrophilic poly(N,N-dimethylaminoethyl

submitted time 2017-04-06 Hits1573Downloads1021 Comment 0

2. chinaXiv:201612.00373 [pdf]

Prospect of a very long baseline neutrino oscillation experiment: HIPA to Beijing

H2B-1,VSG; Chen,H; Ding,L; He,J; Kuang,H; Lu,Y; Ma,Y; Shan,L; Shen,C; Wang,Y; Yang,C; Zhang,X; Zhu,Q; Qing,C; Xiong,Z; Yang,JM; Zhang,Z; Chen,J; Ye,Y; Lee,S

We discuss the prospects of a very long baseline neutrino oscillation experiment from HIPA to Beijing. The current understanding of neutrino oscillations, both theoretically and experimentally, are summarized. The figure of merits for interested physics m

submitted time 2016-12-28 Hits2071Downloads1119 Comment 0

3. chinaXiv:201605.01185 [pdf]

A long noncoding RNA critically regulates Bcr-Abl-mediated cellular transformation by acting as a competitive endogenous RNA

Guo, G.; Kang, Q.; Zhu, X.; Wang, X.; Chen, Y.; Ouyang, J.; Chen, J-L; Zhu, X.; Chen, Q.; Zhang, L.; Zhang, L.; Tan, H.; Chen, R.; Huang, S.
Subjects: Biology >> Biophysics >> Biochemistry & Molecular Biology

Aberrant expression of long noncoding RNAs (lncRNAs) is associated with various human cancers. However, the role of lncRNAs in Bcr-Abl-mediated chronic myeloid leukemia (CML) is unknown. In this study, we performed a comprehensive analysis of lncRNAs in human CML cells using an lncRNA cDNA microarray and identified an lncRNA termed lncRNA-BGL3 that acted as a key regulator of Bcr-Abl-mediated cellular transformation. Notably, we observed that lncRNA-BGL3 was highly induced in response to disruption of Bcr-Abl expression or by inhibiting Bcr-Abl kinase activity in K562 cells and leukemic cells derived from CML patients. Ectopic expression of lncRNA-BGL3 sensitized leukemic cells to undergo apoptosis and inhibited Bcr-Abl-induced tumorigenesis. Furthermore, transgenic (TG) mice expressing lncRNA-BGL3 were generated. We found that TG expression of lncRNA-BGL3 alone in mice was sufficient to impair primary bone marrow transformation by Bcr-Abl. Interestingly, we identified that lncRNA-BGL3 was a target of miR-17, miR-93, miR-20a, miR-20b, miR-106a and miR-106b, microRNAs that repress mRNA of phosphatase and tensin homolog (PTEN). Further experiments demonstrated that lncRNA-BGL3 functioned as a competitive endogenous RNA for binding these microRNAs to cross-regulate PTEN expression. Additionally, our experiments have begun to address the mechanism of how lncRNA-BGL3 is regulated in the leukemic cells and showed that Bcr-Abl repressed lncRNA-BGL3 expression through c-Myc-dependent DNA methylation. Taken together, these results reveal that Bcr-Abl-mediated cellular transformation critically requires silence of tumor-suppressor lncRNA-BGL3 and suggest a potential strategy for the treatment of Bcr-Abl-positive leukemia.

submitted time 2016-05-11 Hits2190Downloads1099 Comment 0

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