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1. chinaXiv:202002.00080 [pdf]

Transplantation of ACE2- mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia

Zikuan Leng; Rongjia Zhu; Wei Hou; Yingmei Feng; Yanlei Yang; Qin Han; Guangliang Shan; Fanyan Meng; Dongshu Du; Shihua Wang; Junfen Fan; Wenjing Wang; Luchan Deng; Hongbo Shi; Hongjun Li; Zhongjie Hu; Fengchun Zhang; Jinming Gao; Hongjian Liu; Xiaoxia Li
Subjects: Medicine, Pharmacy >> Clinical Medicine

A coronavirus (HCoV-19) has caused the novel coronavirus disease (COVID-19) outbreak in Wuhan, China, Preventing and reversing the cytokine storm may be the key to save the patients with severe COVID-19 pneumonia. Mesenchymal stem cells (MSCs) have been shown to possess a comprehensive powerful immunomodulatory function. This study aims to investigate whether MSC transplantation improve the outcome of 7 enrolled patients with COVID-19 pneumonia in Beijing YouAn Hospital, China from Jan 23, 2020. to Feb 16, 2020. The clinical outcomes, as well as changes of inflammatory and immune function levels and adverse effects of 7 enrolled patients were assessed for 14 days after MSC injection. MSCs could cure or significantly improve the functional outcomes of seven patients with COVID-19 pneumonia in 14 days without observed adverse effect. The pulmonary function and symptoms of all patients with COVID-19 pneumonia were significantly improved in 2 days after MSC transplantation. Among them, two common and one severe patient were recovered and discharged in 10 days after treatment. After treatment, the peripheral lymphocytes were increased and the overactivated cytokine-secreting immune cells CXCR3 CD4 T cells, CXCR3 CD8 T cells, and CXCR3 NK cells were disappeared in 3-6 days. And a group of CD14 CD11c CD11bmid regulatory DC cell population dramatically increased. Meanwhile, the level TNF-α is significantly decreased while IL-10 increased in MSC treatment group compared to the placebo control group. Furthermore, the gene expression profile showed MSCs were ACE2- and TMPRSS2- which indicated MSCs are free from COVID-19 infection. Thus, the intravenous transplantation of MSCs was safe and effective for treatment in patients with COVID-19 pneumonia, especially for the patients in critically severe condition.

submitted time 2020-02-28 Hits12024Downloads2623 Comment 0

2. chinaXiv:201609.00969 [pdf]

Leptonic Decay Constant of $\rho$ at Physical Point

Ying Chen; Andrei Alexandru; Terrence Draper; Keh-Fei Liu; Zhaofeng Liu; Yi-Bo Yang
Subjects: Physics >> Nuclear Physics

The ρ meson leptonic decay constant at the physical pion mass is calculated with chiral fermions. Overlap valence quarks are used on the L3×T=483×96 Nf=2+1 domain-wall fermion configurations with light sea quarks at the physical point and the spatial extension of 5.5 fm. The mass of the vector meson ρ is determined to be mρ=775.9±6.0±1.8 MeV, and the valence πρ sigma term is extracted to be σ(val)πρ=9.82(6) MeV from Feynmann-Hellman theorem. By adopting a new method to reduce the noise of the wall-wall correlation functions of hadrons, we obtain the ρ leptonic decay constant fρ=208.5±5.5±0.9 MeV, which is in very good agreement with the experimental value fρ=209.4±1.5 MeV derived from the τ decay τ→ρντ.

submitted time 2016-09-14 Hits135Downloads87 Comment 0

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