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1. chinaXiv:201707.00474 [pdf]

Cycloheximide congeners produced by Streptomyces sp. SC0581 and photoinduced interconversion between (E)- and (Z)-2,3-dehydro-anhydrocycloheximides

Yang, Li; Wu, Ping; Xue, Jinghua; Tan, Huitong; Zhang, Zheng; Wei, Xiaoyi
分类: 生物学 >> 植物学

Three new cycloheximide congeners, 2,3-dehydro--epi-isocycloheximide (1), (E)- and (Z)-2,3-dehydro-anhydrocycloheximides (2 and 3), together with three known compounds, anhydroisoheximide (4), cycloheximide (5), and isocycloheximide (6), were obtained from the cultures of Streptomyces sp. SC0581. Their structures were elucidated by extensive spectroscopic analysis in combination with theoretical conformational analysis and ECD computations. The photoinduced interconversion between 2 and 3 was observed and verified and the possible reaction path and mechanism were proposed by theoretical computations. The antifungal and cytotoxic activities of 1–6 were evaluated and suggested that 2,3-dehydrogenation results in the loss of the activities and supported the OH- is important to the activities of cycloheximide congeners.

提交时间: 2017-07-14 点击量219, 下载量115

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