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1. chinaXiv:201707.00474 [pdf]

Cycloheximide congeners produced by Streptomyces sp. SC0581 and photoinduced interconversion between (E)- and (Z)-2,3-dehydro-anhydrocycloheximides

Yang, Li; Wu, Ping; Xue, Jinghua; Tan, Huitong; Zhang, Zheng; Wei, Xiaoyi
分类: 生物学 >> 植物学

Three new cycloheximide congeners, 2,3-dehydro--epi-isocycloheximide (1), (E)- and (Z)-2,3-dehydro-anhydrocycloheximides (2 and 3), together with three known compounds, anhydroisoheximide (4), cycloheximide (5), and isocycloheximide (6), were obtained from the cultures of Streptomyces sp. SC0581. Their structures were elucidated by extensive spectroscopic analysis in combination with theoretical conformational analysis and ECD computations. The photoinduced interconversion between 2 and 3 was observed and verified and the possible reaction path and mechanism were proposed by theoretical computations. The antifungal and cytotoxic activities of 1–6 were evaluated and suggested that 2,3-dehydrogenation results in the loss of the activities and supported the OH- is important to the activities of cycloheximide congeners.

提交时间: 2017年07月14日 点击量:100, 下载量:50

2. chinaXiv:201605.01296 [pdf]

Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion

Zhang, Zheng; Zhao, Juanjuan; Wang, Fu-Sheng; Zhang, Zheng; Cheng, Liang; Li, Guangming; Reszka-Blanco, Natalia J.; Sum, Lishan; Zhang, Zheng; Zhao, Juanjuan; Zhang, Liguo; Sum, Lishan; Chen, Weiwei; Nie, Weiming; Wang, Fu-Sheng
分类: 生物学 >> 生物物理学

Group 3 innate lymphoid cells (ILC3s) have demonstrated roles in promoting antibacterial immunity, maintaining epithelial barrier function, and supporting tissue repair. ILC3 alterations are associated with chronic inflammation and inflammatory disease; however, the characteristics and relevant regulatory mechanisms of this cell population in HIV-1 infection are poorly understood due in part to a lack of a robust model. Here, we determined that functional human ILC3s develop in lymphoid organs of humanized mice and that persistent HIV-1 infection in this model depletes ILC3s, as observed in chronic HIV-1-infected patients. In HIV-1-infected mice, effective antiretroviral therapy reversed the loss of ILC3s. HIV-1-dependent reduction of ILC3s required plasmacytoid dendritic cells (pDCs), IFN-I, and the CD95/FasL pathway, as targeted depletion or blockade of these prevented HIV-1-induced ILC3 depletion in vivo and in vitro, respectively. Finally, we determined that HIV-1 infection induces CD95 expression on ILC3s via a pDC- and IFN-I-dependent mechanism that sensitizes ILC3s to undergo CD95/FasL-mediated apoptosis. We conclude that chronic HIV-1 infection depletes ILC3s through pDC activation, induction of IFN-I, and CD95-mediated apoptosis.

提交时间: 2016年05月11日 点击量:48, 下载量:39

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