摘要: Thirteen new pentacyclic triterpenoids, cleistocalyxic acids AK (1, 2, 4, 5, and 713) and cleistocalyxolides A (3) and B (6), and fifteen known analogues (1428), based on taraxastane, oleanane, ursane, multiflorane, and lupane skeletons, were isolated from the leaves of Cleistocalyx operculatus. The structures of 113 were elucidated by analysis of their spectroscopic data and ECD/TDDFT computations. Cleistocalyxolide A (3), presumed to be derived from the known taraxastane-type compound 14, has a rare rearranged triterpenoid backbone. Cleistocalyxic acid B (2) displayed cytotoxicity against HepG2, NCI-N87, and MCF-7 cancer cell lines with IC50 values ranging from 3.2 to 6.5 M and cleistocalyxic acid D (5) was active against HepG2 and NCI-N87 cells with the values around 5.0 M. The non-cytotoxic cleistocalyxic acid E (7) inhibited production of IL-6 by 68.1% and TNF- by 53.7% in LPS-induced RAW 264.7 macrophages at the concentration of 2 M.
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来自:
许秋生
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分类:
生物学
>>
生物化学
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引用:
ChinaXiv:201705.00892
(或此版本
ChinaXiv:201705.00892V1)
doi:10.12074/201705.00892
CSTR:32003.36.ChinaXiv.201705.00892.V1
- 推荐引用方式:
Wang, Chen,Wu, Ping,Tian, Shuai,Xue, Jinghua,Xu, Liangxiong,Li, Hanxiang,Wei, Xiaoyi.(2017).Bioactive Pentacyclic Triterpenoids from the Leaves of Cleistocalyx operculatus.中国科学院科技论文预发布平台.[ChinaXiv:201705.00892]
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