摘要: Three new cycloheximide congeners, 2,3-dehydro--epi-isocycloheximide (1), (E)- and (Z)-2,3-dehydro-anhydrocycloheximides (2 and 3), together with three known compounds, anhydroisoheximide (4), cycloheximide (5), and isocycloheximide (6), were obtained from the cultures of Streptomyces sp. SC0581. Their structures were elucidated by extensive spectroscopic analysis in combination with theoretical conformational analysis and ECD computations. The photoinduced interconversion between 2 and 3 was observed and verified and the possible reaction path and mechanism were proposed by theoretical computations. The antifungal and cytotoxic activities of 1–6 were evaluated and suggested that 2,3-dehydrogenation results in the loss of the activities and supported the OH- is important to the activities of cycloheximide congeners.
-
来自:
许秋生
-
分类:
生物学
>>
植物学
-
引用:
ChinaXiv:201707.00474
(或此版本
ChinaXiv:201707.00474V1)
doi:10.12074/201707.00474
CSTR:32003.36.ChinaXiv.201707.00474.V1
- 推荐引用方式:
Yang, Li,Wu, Ping,Xue, Jinghua,Tan, Huitong,Zhang, Zheng,Wei, Xiaoyi.(2017).Cycloheximide congeners produced by Streptomyces sp. SC0581 and photoinduced interconversion between (E)- and (Z)-2,3-dehydro-anhydrocycloheximides.中国科学院科技论文预发布平台.[ChinaXiv:201707.00474]
(点此复制)